| Sen_G_0001 | MYC | 4609 | BAG2 | Downregulation | Unclear | P53-P21 | Upregulation | protein coding | TRE293 | -- | Aging | Prevent | | HL | 22146591 |
| Sen_G_0002 | NLRX1 | 79671 | P21 | Upregulation | Phosphorylation | PI3K-AKT | Downregulation | protein coding | HCCLM3 | -- | Hepatocellular carcinoma | Accelerate | | HL | 29482578 |
| Sen_G_0003 | PRKAA1 | 5562 | LC3//P62 | Downregulation//Downregulation | Unclear | MTOR | Downregulation | protein coding | NIH-3T3 | -- | Aging | Prevent | | L | 26890602 |
| Sen_G_0004 | IGFBP7 | 3490 | P21//P53 | Upregulation//Upregulation | Unclear | P38 MAPK | Upregulation | protein coding | MDA-MB-231 | -- | Breast cancer | Accelerate | | L | 21997538 |
| Sen_G_0005 | MEF2A | 4205 | P53 | Downregulation | Binding to promoter | PI3K-P-AKT-SIRT1 | Upregulation | protein coding | HUVEC | Human umbilical vein | Cardiovascular disease | Prevent | Others | L | 31182679 |
| Sen_G_0006 | MIR584 | 693169 | WWP1//P53 | Downregulation//Upregulation | Unclear | TGFβ | Activation | ncRNA | MGC803,SGC-7901 | -- | Gastric cancer | Accelerate | | HL | 28431583 |
| Sen_G_0007 | TP53 | 7157 | P21//AKT | --//Activation | Unclear | NF-κB-NOX4 | -- | protein coding | EJ | -- | Aging | Accelerate | | L | 28691365 |
| Sen_G_0008 | NAMPT | 10135 | SIRT1 | Upregulation | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | | L | 29178516 |
| Sen_G_0009 | SIRT1 | 23411 | P53 | Inhibition | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 12006491 |
| Sen_G_0009 | SIRT1 | 23411 | P53 | Inhibition | Acetylation | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 12006491 |
| Sen_G_0010 | CDK5 | 1020 | RAC1 | Downregulation | Unclear | -- | -- | protein coding | Saos-2 | -- | Aging | Accelerate | | L | 15024070 |
| Sen_G_0011 | MORC3 | 23515 | P53 | Activation | Phosphorylation | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 17332504 |
| Sen_G_0012 | IGFBPL1 | 347252 | P21 | Upregulation | Phosphorylation | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 22392074 |
| Sen_G_0013 | GADD45G | 10912 | SIP1 | Upregulation | Unclear | -- | -- | protein coding | SK-Hep-1,SMMC-7721 | -- | Hepatocellular carcinoma | Accelerate | | HL | 26378039 |
| Sen_G_0014 | HMGA2 | 8091 | E2F | Downregulation | Unclear | RB | -- | protein coding | WI-38 | -- | Retinoblastoma | Accelerate | | L | 23969248 |
| Sen_G_0015 | RRAD | 6236 | P53//NF-κB | --//-- | Unclear | -- | -- | protein coding | NHF | -- | Aging | Prevent | | HL | 30391675 |
| Sen_G_0016 | ING1 | 3621 | P16 | Upregulation | Binding to promoter | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 21896275 |
| Sen_G_0017 | TWIST | 100303576 | P14//CH2AX | Downregulation//Upregulation | Unclear | MDM2-P53 | -- | protein coding | SW48 | -- | Aging | Prevent | | L | 17690110 |
| Sen_G_0018 | CAV1 | 857 | SIRT1 | Inhibition | Phosphorylation | P53 | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 25512378 |
| Sen_G_0018 | CAV1 | 857 | SIRT1 | Inhibition | Acetylation | P53 | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 25512378 |
| Sen_G_0019 | NQO1 | 1728 | P53 | Upregulation | Phosphorylation | NRF2-KEAP1 | -- | protein coding | 2BS | -- | Aging | Accelerate | | HL | 26078718 |
| Sen_G_0020 | RSL1D1 | 26156 | PTEN | Downregulation | Unclear | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | L | 26686419 |
| Sen_G_0021 | S100A13 | 6284 | IL-1 | Upregulation | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 30670674 |
| Sen_G_0022 | TRIB2 | 28951 | -- | -- | Unclear | AP4-P21 | -- | protein coding | LoVo | -- | Colorectal cancer | Prevent | | L | 30541550 |
| Sen_G_0023 | LBR | 3930 | -- | -- | Unclear | -- | -- | protein coding | TIG-7 | -- | Aging | Prevent | | L | 30615890 |
| Sen_G_0024 | PTEN | 5728 | -- | -- | Unclear | P53-P21 | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 30337688 |
| Sen_G_0025 | MDM2 | 4193 | WRN | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Werner syndrome | Accelerate | | L | 30532073 |
| Sen_G_0026 | ASPH | 444 | GSK3β | -- | Unclear | -- | -- | protein coding | FOCUS,HuH-7,HepG2 | -- | Hepatocellular carcinoma | Prevent | | L | 26683595 |
| Sen_G_0027 | RXRA | 6256 | P53 | -- | Unclear | ITPR2-MCU | -- | protein coding | MRC-5 | -- | Aging | Prevent | | HL | 30216632 |
| Sen_G_0028 | LRRK2 | 120892 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | SH-SY5Y | -- | Parkinson’s disease | Accelerate | | L | 30712480 |
| Sen_G_0029 | TSHB | 7252 | -- | -- | Unclear | -- | -- | protein coding | -- | Adipose | Aging | Prevent | | L | 30448824 |
| Sen_G_0030 | FXR1 | 8087 | TERC | Inhibition | Unclear | P53-P21 | -- | protein coding | UMSCC74A,UMSCC74B | -- | Oral cancer | Prevent | | HL | 27606879 |
| Sen_G_0031 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | DFC | -- | Aging | Accelerate | | HL | 28770470 |
| Sen_G_0032 | SIRT6 | 51548 | P27 | -- | Unclear | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | HL | 27794562 |
| Sen_G_0033 | TIMELESS | 8914 | E2F1 | -- | Binding to promoter | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | L | 30100061 |
| Sen_G_0034 | TSLP | 85480 | -- | -- | Unclear | -- | -- | protein coding | BEAS-2B | -- | Asthma | Accelerate | | L | 24167583 |
| Sen_G_0035 | UHRF1 | 29128 | PIM1 | -- | Phosphorylation | -- | -- | protein coding | 2BS,IMR-90 | -- | Aging | Prevent | | HL | 28394343 |
| Sen_G_0036 | WNT7A | 7476 | -- | -- | Unclear | SKP2-P27-PRB | -- | protein coding | A549 | Lung | Lung cancer | Accelerate | | HL | 25728679 |
| Sen_G_0037 | SPHK1 | 8877 | S1P | -- | Unclear | -- | -- | protein coding | Adipose stromal cell | -- | Aging | Prevent | | L | 30885289 |
| Sen_G_0038 | IGF1 | 3479 | -- | -- | Unclear | ROS-P53 | -- | protein coding | VSMC | -- | Aging | Accelerate | | L | 22877754 |
| Sen_G_0039 | SETD8 | 387893 | PPARC//P21 | --//Downregulation | Unclear | -- | -- | protein coding | PC-3 | -- | Aging | Prevent | | HL | 28514051 |
| Sen_G_0040 | YPEL3 | 83719 | P53 | -- | Unclear | -- | -- | protein coding | MCF-7,U2OS | -- | Aging | Accelerate | | HL | 20388804 |
| Sen_G_0041 | IFNG | 3458 | P53 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 19071156 |
| Sen_G_0042 | HDAC4 | 9759 | SIRT1 | -- | Unclear | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | L | 26414199 |
| Sen_G_0043 | ACLY | 47 | -- | -- | Unclear | P53-AMPK | -- | protein coding | HDF | -- | Aging | Prevent | | L | 25367309 |
| Sen_G_0044 | PIR | 8544 | -- | -- | Unclear | -- | -- | protein coding | WM266-4,IGR-37 | -- | Aging | Prevent | | L | 21514450 |
| Sen_G_0045 | CUL4B | 8450 | -- | -- | Unclear | P53-ROS | Downregulation | protein coding | NHF,U2OS | -- | Aging | Prevent | | L | 25464270 |
| Sen_G_0046 | IGFBP5 | 3488 | P53 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | HL | 17804819 |
| Sen_G_0047 | PLY | 5601825 | -- | -- | Phosphorylation | MAPK-NF-κB | Activation | protein coding | BV-2,C6 | -- | Aging | Accelerate | | L | 28232188 |
| Sen_G_0048 | MCAM | 4162 | -- | -- | Unclear | -- | -- | protein coding | CD1462,CD146+ | -- | Aging | Prevent | | L | 26941359 |
| Sen_G_0049 | TFAP4 | 7023 | -- | -- | Binding to promoter | P14-P53 | Activation | protein coding | RPE | -- | Aging | Accelerate | | HL | 26439195 |
| Sen_G_0050 | AGR2 | 10551 | -- | -- | Unclear | -- | -- | protein coding | LNCaP,DU 145,PC-3 | -- | Aging | Prevent | | HL | 22467239 |
| Sen_G_0051 | PLK1 | 5347 | -- | -- | Unclear | P53 | -- | protein coding | HDF,HUVEC | -- | Aging | Prevent | | HL | 23525475 |
| Sen_G_0052 | HJURP | 55355 | -- | -- | Unclear | P53 | -- | protein coding | HDF,HUVEC | -- | Aging | Prevent | | HL | 23292286 |
| Sen_G_0053 | ERRFI1 | 54206 | FOXO3A | -- | Unclear | EGFR-ERBB | Downregulation | protein coding | 2BS | -- | Aging | Accelerate | | HL | 23746120 |
| Sen_G_0054 | ING1 | 3621 | -- | -- | Unclear | P53 | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 21078114 |
| Sen_G_0055 | SIRT6 | 51548 | -- | -- | Unclear | ERK//SMAD//P38 MAPK | --//--//-- | protein coding | HepG2 | -- | Aging | Prevent | | L | 25683165 |
| Sen_G_0056 | MYC | 4609 | AP4//P53 | --//-- | Unclear | -- | -- | protein coding | RPE | -- | Aging | Accelerate | | L | 29188535 |
| Sen_G_0057 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | Lymphoma cell line | -- | Acute leukemia | Accelerate | | HL | 25784651 |
| Sen_G_0058 | ATF7IP | 55729 | -- | -- | Unclear | RB | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 23935871 |
| Sen_G_0059 | TNFSF13 | 8741 | -- | -- | Unclear | HSPG | -- | protein coding | SW480 | -- | Colorectal cancer | Prevent | | L | 19466596 |
| Sen_G_0060 | GNG11 | 2791 | -- | -- | Unclear | ERK1/2 | Activation | protein coding | Fibroblast | -- | Aging | Accelerate | | L | 17092487 |
| Sen_G_0061 | MDH1 | 4190 | SIRT1 | Inhibition | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | L | 22971926 |
| Sen_G_0062 | SMARCB1 | 6598 | -- | -- | Unclear | P16-PRB | -- | protein coding | Lac-hSNF5 | -- | Malignant Rhabdoid Tumor | Accelerate | | L | 14604992 |
| Sen_G_0063 | WWP1 | 11059 | -- | -- | Unclear | P27 | -- | protein coding | 2BS | -- | Aging | Prevent | | HL | 21795702 |
| Sen_G_0064 | ATP6V0A2 | 23545 | -- | -- | Unclear | -- | -- | protein coding | TIG-1 | -- | Aging | Prevent | | L | 26611489 |
| Sen_G_0065 | KIF2C | 11004 | -- | -- | Unclear | P53 | -- | protein coding | HDF,HUVEC | -- | Aging | Prevent | | HL | 23098759 |
| Sen_G_0066 | CREG1 | 8804 | P16 | Upregulation | Binding to promoter | -- | -- | protein coding | Fibroblast | -- | Li-Fraumeni Syndrome | Accelerate | | HL | 21263217 |
| Sen_G_0067 | TOPBP1 | 11073 | -- | -- | Unclear | -- | -- | protein coding | MEF,3T3 | -- | Aging | Prevent | | L | 21149450 |
| Sen_G_0068 | GRSF1 | 2926 | IL-6 | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | L | 30086537 |
| Sen_G_0069 | PRKAA1 | 5562 | SOD2//SIRT3 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | BEAS-2B | Lung | Chronic obstructive pulmonary disease | Prevent | | L | 28186975 |
| Sen_G_0070 | SLC25A5 | 292 | NF1/SMAD | -- | Unclear | TGFβ | -- | protein coding | U2OS,MCF-7 | -- | Aging | Prevent | | L | 25220407 |
| Sen_G_0071 | TP53 | 7157 | -- | -- | Unclear | HSMG-1-RPL26-SRSF7 | -- | protein coding | MCF-7,A549,HCT116 | -- | Aging | Accelerate | | HL | 28288992 |
| Sen_G_0072 | SRSF3 | 6428 | TP53 | Downregulation | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 22777358 |
| Sen_G_0073 | EZH2 | 2146 | P21 | Inhibition | Unclear | -- | -- | protein coding | SK-Mel-119,UCD-Mel-N,SK-Mel-173 | -- | Melanocytic nevi | Prevent | | L | 21383005 |
| Sen_G_0074 | TAGLN | 6876 | MT-1G | Upregulation | Unclear | P16-PRB | Activation | protein coding | HepG2 | -- | Aging | Accelerate | | L | 20705054 |
| Sen_G_0075 | SLC13A3 | 64849 | -- | -- | Unclear | SIRT1 | Downregulation | protein coding | WI-38 | -- | Aging | Accelerate | | L | 20813124 |
| Sen_G_0076 | PRDX3 | 10935 | P16//P21//P38 | --//--//-- | Unclear | -- | -- | protein coding | HTR8,Human primary trophoblast | -- | Intrahepatic cholestasis of pregnancy | Prevent | | HL | 27958341 |
| Sen_G_0077 | UBE2E3 | 10477 | -- | -- | Unclear | P53-P21 | -- | protein coding | RPE-1 | -- | Aging | Prevent | | L | 29879550 |
| Sen_G_0078 | FAHD1 | 81889 | P53//P21/WAF1 | --//-- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 28286170 |
| Sen_G_0079 | KCNH7 | 90134 | -- | -- | Unclear | RAF-MEK-ERK | -- | protein coding | A375 | -- | Melanoma | Accelerate | | L | 26942884 |
| Sen_G_0080 | CIP2A | 57650 | -- | -- | Unclear | -- | -- | protein coding | HCC | -- | Hepatocellular carcinoma | Prevent | | HL | 29175329 |
| Sen_G_0081 | SFRP1 | 6422 | -- | -- | Unclear | WNT-β-CATENIN//RB//P53 | Downregulation//Activation//-- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 22927647 |
| Sen_G_0082 | EZH2 | 2146 | P21 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Prevent | | HL | 27882937 |
| Sen_G_0083 | RRM2 | 6241 | -- | -- | Unclear | -- | -- | protein coding | SKOV3 EOC | -- | Epithelial ovarian cancer | Prevent | | HL | 24200970 |
| Sen_G_0084 | SUV39H1 | 6839 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 25063769 |
| Sen_G_0085 | CCN1 | 3491 | -- | -- | Unclear | RAC1-NOX1-ROS | -- | protein coding | MyoFibroblast | -- | Liver disease | Accelerate | | L | 23508104 |
| Sen_G_0086 | MAGEA2 | 4101 | PMLIV | -- | Unclear | PML-P53 | Upregulation | protein coding | WI-38 | -- | Tumor | Prevent | | L | 22117195 |
| Sen_G_0087 | FOXO3 | 2309 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | L | 15741276 |
| Sen_G_0088 | AGT | 183 | BCL-2//ERK | Downregulation//Activation | Unclear | -- | -- | protein coding | HUVEC | -- | Atherosclerosis | Accelerate | | L | 18383564 |
| Sen_G_0089 | TGFB1 | 7040 | -- | -- | Unclear | NF-κB | Activation | protein coding | HCEC | -- | Aging | Accelerate | | L | 27713146 |
| Sen_G_0090 | CSNK2A1 | 1457 | P52//RB | --//-- | Phosphorylation | P53-P21 | Activation | protein coding | HCT116 | -- | Aging | Prevent | | L | 19855935 |
| Sen_G_0091 | BAG2 | 836330 | -- | -- | Unclear | P21 | Activation | protein coding | TRE293 | -- | Aging | Accelerate | | HL | 22146591 |
| Sen_G_0092 | GRK4 | 2868 | -- | -- | Unclear | -- | -- | protein coding | HEK293 | -- | Aging | Accelerate | | L | 28912086 |
| Sen_G_0093 | TAK1 | 39659 | P53 | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 25118260 |
| Sen_G_0094 | BTG3 | 492479 | JMJD3 | -- | Unclear | ERK-AP1 | -- | protein coding | HCT116 | -- | Aging | Prevent | | HL | 22020331 |
| Sen_G_0095 | RRN3 | 54700 | -- | -- | Unclear | P53-P21 | Activation | protein coding | MCF-7,MEF | -- | Aging | Accelerate | | L | 25732822 |
| Sen_G_0096 | PON1 | 5444 | P16 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | L | 22897574 |
| Sen_G_0097 | SMARCA4 | 6597 | -- | -- | Unclear | SIRT1-P53-P21 | -- | protein coding | SW48 | -- | Colorectal cancer | Prevent | | L | 28182012 |
| Sen_G_0098 | PPARD | 5467 | RASGRP1//ILK | --//Downregulation | Unclear | PI3K-AKT//MEK-ERK | Downregulation//Upregulation | protein coding | Primary keratinocyte | -- | Skin cancer | Accelerate | | HL | 24213576 |
| Sen_G_0099 | HDAC1 | 3065 | -- | -- | Unclear | -- | -- | protein coding | UCB-MSC | -- | Aging | Prevent | | HL | 20652617 |
| Sen_G_0100 | HDAC2 | 3066 | -- | -- | Unclear | -- | -- | protein coding | UCB-MSC | -- | Aging | Prevent | | HL | 20652617 |
| Sen_G_0101 | BHLHE40 | 8553 | P53 | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | HL | 18025081 |
| Sen_G_0102 | SLC13A3 | 64849 | NADH | Upregulation | Unclear | -- | -- | protein coding | MRC-5,WI-38 | -- | Aging | Accelerate | | L | 25384549 |
| Sen_G_0103 | DIRAS3 | 9077 | -- | -- | Unclear | AKT-MTOR | Downregulation | protein coding | ASC | -- | Aging | Prevent | | L | 28316325 |
| Sen_G_0104 | EZH2 | 2146 | -- | -- | Unclear | INK-ARF-RB | -- | protein coding | SKOV3/DDP | -- | Ovaria cancer | Prevent | | HL | 27610467 |
| Sen_G_0105 | UBE3A | 7337 | -- | -- | Unclear | PML | Upregulation | protein coding | Human Burkitt Lymphoma cell line derived cell line | -- | B-cell lymphoma | Prevent | | L | 22689861 |
| Sen_G_0106 | DNMT1 | 1786 | P16//P21/WAF1//EZH2//BMI1//MIR200C//MIR-214 | --//--//--//--//--//-- | Unclear | -- | -- | protein coding | UCB-MSC | -- | Aging | Prevent | | HL | 21572997 |
| Sen_G_0107 | SIRT1 | 23411 | -- | -- | Phosphorylation | P16-RB//ERK-S6K1 | --//Activation | protein coding | 2BS | -- | Aging | Prevent | | L | 18320031 |
| Sen_G_0108 | TBX2 | 6909 | PML | Downregulation | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 22002537 |
| Sen_G_0109 | NUAK1 | 9891 | LKB1//LATS1 | Activation//Downregulation | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | HL | 19927127 |
| Sen_G_0110 | LATS1 | 9113 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 19927127 |
| Sen_G_0111 | GDF15 | 9518 | -- | -- | Unclear | ALK1-SMAD1 | Activation | protein coding | TBE | -- | Aging | Accelerate | | HL | 27093475 |
| Sen_G_0112 | AKTIP | 64400 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Prevent | | L | 27512140 |
| Sen_G_0113 | PPM1B | 5495 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 24674756 |
| Sen_G_0114 | RPS14 | 6208 | CDK4//CYCLIN D1 | --//-- | Phosphorylation Unclear | RB | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 29941930 |
| Sen_G_0115 | ERBB2 | 2064 | -- | -- | Unclear | MEK-ERK//PI3K-AKT | Activation//-- | protein coding | -- | Prostate | Prostate cancer | Prevent | | HL | 21930937 |
| Sen_G_0116 | SIRT3 | 23410 | -- | -- | Unclear | FOXO1 | Upregulation | protein coding | WI-38 | -- | Aging | Prevent | | L | 23494737 |
| Sen_G_0117 | AKT1 | 207 | MIR-182//MIR-200//HMGA2 | --//--//-- | Unclear | -- | -- | protein coding | Primary leiomyoma cell | -- | Uterine leiomyomas | Prevent | | L | 24476133 |
| Sen_G_0118 | CPT1C | 126129 | -- | -- | Unclear | -- | -- | protein coding | PANC-1 | -- | Pancreatic cancer | Prevent | | L | 29317762 |
| Sen_G_0119 | MIF | 4282 | -- | -- | Unclear | AKT | Activation | protein coding | MSC | -- | Aging | Prevent | | HL | 24274936 |
| Sen_G_0120 | IGFBP3 | 3486 | AKT | Inhibition | Unclear | P53//RB | --//-- | protein coding | MCF-7,IMR-90 | -- | Aging | Accelerate | | L | 22778398 |
| Sen_G_0121 | SERPINE1 | 5054 | T-PA//IGFBP3 | --//-- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 22778398 |
| Sen_G_0122 | AGO2 | 27161 | E2F//RB1//LET-7F | --//--//-- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | HL | 22366686 |
| Sen_G_0123 | YAP1 | 10413 | -- | -- | Unclear | YAP-TEAD//YAP-FOXD1 | --//-- | protein coding | MSC | -- | Osteoarthritis | Prevent | | HL | 30933975 |
| Sen_G_0124 | ING1 | 3621 | P16//P27//AR | Upregulation//--//-- | Unclear | -- | -- | protein coding | PCa | -- | Prostate cancer | Accelerate | | HL | 26993046 |
| Sen_G_0125 | TGFB1 | 7040 | P21 | Upregulation | Unclear | -- | -- | protein coding | HBEC | -- | Idiopathic pulmonary fibrosis | Accelerate | | L | 21224216 |
| Sen_G_0126 | SIRT6 | 51548 | TGF-β | Downregulation | Unclear | -- | -- | protein coding | HBEC | -- | Idiopathic pulmonary fibrosis | Prevent | | L | 21224216 |
| Sen_G_0127 | SIRT1 | 23411 | C-MYC | Inhibition | Unclear | -- | -- | protein coding | HDF | -- | Colorectal cancer | Prevent | | HL | 22190494 |
| Sen_G_0128 | DUSP3 | 1845 | -- | -- | Unclear | -- | -- | protein coding | HeLa,MeWo | -- | Cervical cancer | Prevent | | L | 28389334 |
| Sen_G_0129 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | Human Nucleus pulposus cell | -- | Disc degenerative disease | Prevent | | L | 27792110 |
| Sen_G_0130 | SRSF2 | 6427 | -- | -- | Unclear | -- | -- | protein coding | HAoEC | -- | Aging | Prevent | | HL | 30026406 |
| Sen_G_0131 | HNRNPD | 3184 | -- | -- | Unclear | -- | -- | protein coding | HAoEC | -- | Aging | Prevent | | HL | 30026406 |
| Sen_G_0132 | CSNK1A1 | 1452 | -- | -- | Unclear | P53 | -- | protein coding | IMR-90 | -- | Colorectal cancer | Prevent | | HL | 21331045 |
| Sen_G_0133 | CSF2 | 1437 | -- | -- | Unclear | -- | -- | protein coding | SH-SY5Y | -- | Aging | Accelerate | | L | 30807472 |
| Sen_G_0134 | FOXM1 | 2305 | NBS1//P-ATM//FHRE | --// --// -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | | HL | 24141789 |
| Sen_G_0135 | NBS1 | 821254 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | HL | 24141789 |
| Sen_G_0136 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 19520256 |
| Sen_G_0137 | SUMO2 | 6613 | -- | -- | Unclear | P53 | -- | protein coding | NPC | -- | Disc degenerative disease | Accelerate | | L | 29700214 |
| Sen_G_0138 | YAP1 | 10413 | CDK6//CYCLIN B1//P18//P27 | Upregulation//Upregulation//Downregulation//Downregulation | Unclear | ERK | Upregulation | protein coding | h-PDLSC | -- | Aging | Prevent | | L | 30123063 |
| Sen_G_0139 | CDKN1A | 1026 | -- | -- | Unclear | -- | -- | protein coding | MDA-MB-231 | -- | Cancer | Prevent | | L | 26187313 |
| Sen_G_0140 | CAV1 | 857 | -- | -- | Unclear | NRF2 | -- | protein coding | HCT116,NIH-3T3 | -- | Aging | Accelerate | | L | 23637463 |
| Sen_G_0141 | GPX3 | 2878 | CD44//NOX4//SERPINB2 | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | LO2,MIHA | -- | Aging | Prevent | | HL | 29290803 |
| Sen_G_0142 | FOXM1 | 2305 | RB | Downregulation | Unclear | -- | -- | protein coding | H929 | -- | Multiple myeloma | Prevent | | HL | 30463534 |
| Sen_G_0142 | FOXM1 | 2305 | RB | Inhibition | Unclear | -- | -- | protein coding | H929 | -- | Multiple myeloma | Prevent | | HL | 30463534 |
| Sen_G_0143 | IL1B | 3553 | CAVEOLIN-1//P38MAPK//CII | Upregulation//Upregulation//Downregulation | Phosphorylation | -- | -- | protein coding | Osteoarthritic Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 16508959 |
| Sen_G_0144 | CAV1 | 857 | P38MAPK//CII | Upregulation//Downregulation | Phosphorylation | -- | -- | protein coding | Osteoarthritic Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 16508959 |
| Sen_G_0145 | FN1 | 2335 | -- | -- | Unclear | PI3K-AKT | Activation | protein coding | U251,T98G | -- | Aging | Prevent | | HL | 30048971 |
| Sen_G_0146 | PTTG1 | 9232 | IL-8//GROA | Upregulation//Upregulation | Unclear | CXCR2-P21//NF-κB | Upregulation//Activation | protein coding | MCF-7,MCF 10A | -- | Breast cancer | Accelerate | | HL | 22789011 |
| Sen_G_0147 | SALL1 | 6299 | ATM//H2AX//53BP1//CHK2 | --//--//--//-- | Unclear | P38 MAPK//ERK1/2//MTOR | --//--//Activation | protein coding | MCF-7,MDA,E0771 | -- | Breast cancer | Accelerate | | HL | 29625565 |
| Sen_G_0148 | DUSP1 | 1843 | -- | -- | Unclear | AKT | Downregulation | protein coding | SO-Rb5 | -- | Aging | Accelerate | | L | 30536303 |
| Sen_G_0149 | CIT | 11113 | -- | -- | Unclear | -- | -- | protein coding | Daoy ,ONS-76 | -- | Medulloblastoma | Prevent | | L | 29921697 |
| Sen_G_0150 | KLF4 | 9314 | P21 | Upregulation | Unclear | MIR-203-SURVIVIN-P12 | -- | protein coding | T-REx-293 KLF4,T-REx-HeLa KLF4 | -- | Aging | Accelerate | | HL | 27531889 |
| Sen_G_0151 | PIK3R4 | 30849 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 31356904 |
| Sen_G_0152 | NFKB2 | 4791 | -- | -- | Unclear | -- | -- | protein coding | Primary Fibroblast | -- | Aging | Prevent | | HL | 25255445 |
| Sen_G_0153 | ATM | 472 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | | L | 29352261 |
| Sen_G_0154 | ATR | 545 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | | L | 29352261 |
| Sen_G_0155 | PRKDC | 5591 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | | L | 29352261 |
| Sen_G_0156 | CHUK | 1147 | -- | -- | Unclear | NRF2-NQO1 | Downregulation | protein coding | -- | Tumor tissue | Lung cancer | Accelerate | | HL | 29311298 |
| Sen_G_0157 | PTEN | 5728 | MTORC1//MTORC2//P53 | --//--//Activation | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 30337688 |
| Sen_G_0158 | TP53 | 7157 | EGFR//DYRK1A | Downregulation//Downregulation | Unclear | EGFR-MEK-ERK | Downregulation | protein coding | U87,U2OS | -- | Aging | Accelerate | | L | 30910997 |
| Sen_G_0159 | POLE2 | 5427 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0160 | BARD1 | 580 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0161 | FEN1 | 2237 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0162 | RAD51 | 5888 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0163 | EXO1 | 9156 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0164 | BRCA1 | 672 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0165 | BLM | 641 | -- | -- | Unclear | P53-P21-RB | -- | protein coding | Fibroblast | -- | Aging | Prevent | | HL | 29449545 |
| Sen_G_0166 | SIX1 | 6495 | P16//POLYCOMB | --//-- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 26500063 |
| Sen_G_0167 | PIM1 | 5292 | HP1γ | -- | Unclear | IL-6-STAT3 | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 25040935 |
| Sen_G_0168 | GSK3A | 2931 | GS | -- | Unclear | -- | -- | protein coding | Chang | -- | Aging | Prevent | | L | 18782348 |
| Sen_G_0169 | GSK3B | 2932 | GS | -- | Unclear | -- | -- | protein coding | Chang | -- | Aging | Prevent | | L | 18782348 |
| Sen_G_0170 | EZH2 | 2146 | H3K27ME3//INK4/ARF//P14//P15INK4B//P16 | --//--//--//--//-- | Unclear | P15-RB | -- | protein coding | MKN28,SGC-7901 | -- | Aging | Prevent | | L | 26004298 |
| Sen_G_0171 | PEBP1 | 5037 | P53 | -- | Unclear | RAF-MAPK | Downregulation | protein coding | A549 | -- | Aging | Accelerate | | L | 23814485 |
| Sen_G_0172 | EGF | 1950 | -- | -- | Unclear | -- | -- | protein coding | HME | -- | Aging | Prevent | | L | 25367123 |
| Sen_G_0173 | IFNA1 | 3439 | IFI16//IL-1β//AIM2 | --//Upregulation//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | L | 21471287 |
| Sen_G_0174 | IFNB1 | 3456 | IFI16//IL-1β//AIM2 | --//Upregulation//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | L | 21471287 |
| Sen_G_0175 | CSN2 | 1447 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | HL | 17968325 |
| Sen_G_0176 | BRF1 | 2972 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | HL | 17968325 |
| Sen_G_0177 | CDK4 | 1019 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 29330290 |
| Sen_G_0178 | EGFR | 1956 | P53 | -- | Unclear | MEK-ERK | -- | protein coding | A549 | -- | Aging | Accelerate | | L | 21852385 |
| Sen_G_0179 | HRAS | 3265 | KSR1 | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 25002533 |
| Sen_G_0180 | KIR2DL4 | 3805 | TAK1 | -- | Unclear | -- | -- | protein coding | NK | -- | Aging | Accelerate | | L | 24337384 |
| Sen_G_0181 | IGFBPL1 | 347252 | -- | -- | Unclear | ERK | Downregulation | protein coding | HEC-1A | -- | Endometrial cancer | Accelerate | | L | 29067463 |
| Sen_G_0182 | PATZ1 | 23598 | -- | -- | Unclear | P53 | -- | protein coding | HUVEC | -- | Aging | Prevent | | HL | 22052190 |
| Sen_G_0183 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | SK-Hep-1,HepG2 | -- | Hepatocellular carcinoma | Prevent | | HL | 21527554 |
| Sen_G_0184 | AKR1B1 | 231 | P53 | -- | Unclear | -- | -- | protein coding | Keratinocyte | -- | Aging | Prevent | | L | 21182935 |
| Sen_G_0185 | SP1 | 6667 | P16 | -- | Unclear | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 17225865 |
| Sen_G_0186 | ID1 | 3397 | P21/WAF1//P27 | --//-- | Unclear | -- | -- | protein coding | NPTX | -- | Aging | Prevent | | L | 16686600 |
| Sen_G_0187 | TBX2 | 6909 | P21 | Upregulation | Unclear | -- | -- | protein coding | B16 | -- | Melanoma | Prevent | | L | 15781639 |
| Sen_G_0188 | TNF | 7124 | -- | -- | Unclear | JAK-STAT | Activation | protein coding | HUVEC | -- | Aging | Accelerate | | HL | 29176033 |
| Sen_G_0189 | NOX4 | 50507 | -- | -- | Unclear | -- | -- | protein coding | VSMC | -- | Aging | Prevent | | L | 27655718 |
| Sen_G_0190 | BMI1 | 648 | -- | -- | Unclear | -- | -- | protein coding | UCB-MSC | -- | Aging | Prevent | | L | 27454161 |
| Sen_G_0191 | BAP1 | 8314 | ASXL1/2 | -- | Unclear | P53-P21 | -- | protein coding | HeLa-S3 | -- | Cervical cancer | Accelerate | | L | 26416890 |
| Sen_G_0192 | SOX1 | 6656 | C-MYC//CYCLIN D1//P21//P27//CYCLIN E | Downregulation//Downregulation//Upregulation//Upregulation//Downregulation | Unclear | WNT-β-CATENIN | Downregulation | protein coding | HONE1 | -- | Nasopharyngeal carcinoma | Accelerate | | L | 25427424 |
| Sen_G_0193 | CDCA2 | 157313 | SAMIR-494 | Downregulation | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 24905922 |
| Sen_G_0194 | RBP2 | 5948 | CDKISP16//P21CIP2//P27//HSA-MIR-212 | --//--//--//-- | Unclear | -- | -- | protein coding | SMMC-7721,HepG2 | -- | Hepatocellular carcinoma | Prevent | | HL | 23922798 |
| Sen_G_0195 | NOX1 | 27035 | -- | -- | Unclear | P19//P38 MAPK | Upregulation//Upregulation | protein coding | REF52,TIG-3 | -- | Aging | Accelerate | | L | 23216904 |
| Sen_G_0196 | NOX4 | 50507 | -- | -- | Unclear | P16//P38 MAPK | Upregulation//Upregulation | protein coding | REF52,TIG-3 | -- | Aging | Accelerate | | L | 23216904 |
| Sen_G_0197 | HRAS | 3265 | NOX1//NOX4 | --//-- | Unclear | P53-P21//P16 | Upregulation//Upregulation | protein coding | TIG-3,REF52 | -- | Aging | Accelerate | | L | 23216904 |
| Sen_G_0198 | AKT1 | 207 | CHK2 | -- | Unclear | -- | -- | protein coding | U87 | -- | Glioma | Prevent | | L | 15930307 |
| Sen_G_0199 | RB1 | 5925 | -- | -- | Unclear | -- | -- | protein coding | H1299,H460 | -- | Lung cancer | Accelerate | | HL | 29311118 |
| Sen_G_0200 | MAP2K4 | 6416 | P16//P21//P27 | --//--//-- | Unclear | NF-κB | Activation | protein coding | MEF | -- | Aging | Prevent | | L | 28733031 |
| Sen_G_0201 | CIB1 | 10519 | TRF2 | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | HL | 25012820 |
| Sen_G_0202 | PPIB | 5479 | P27 | -- | Unclear | -- | -- | protein coding | U251 | -- | Glioblastoma | Prevent | | HL | 24272483 |
| Sen_G_0203 | NTN4 | 59277 | ITGB4 | -- | Unclear | -- | -- | protein coding | U251MG | -- | Glioblastoma | Prevent | | L | 24265816 |
| Sen_G_0204 | ITGB4 | 3691 | -- | -- | Unclear | -- | -- | protein coding | U251MG,U-118 MG,T98G,U87 MG | -- | Glioblastoma | Prevent | | L | 24265816 |
| Sen_G_0205 | SORBS2 | 8470 | -- | -- | Unclear | -- | -- | protein coding | Primary human keratinocyte | -- | Aging | Accelerate | | HL | 24165198 |
| Sen_G_0206 | TLR3 | 7098 | -- | -- | Unclear | -- | -- | protein coding | Primary human Fibroblast | -- | Aging | Accelerate | | HL | 24165198 |
| Sen_G_0207 | HDAC7 | 51564 | C-MYC//P21//P27 | --//--//-- | Unclear | -- | -- | protein coding | HeLa,MCF-7 | -- | Cancer | Prevent | | L | 21120446 |
| Sen_G_0208 | IRF5 | 3663 | -- | -- | Unclear | -- | -- | protein coding | MDAH087-1 | -- | Aging | Accelerate | | HL | 18505922 |
| Sen_G_0209 | IRF7 | 3665 | -- | -- | Unclear | -- | -- | protein coding | MDAH087-1 | -- | Aging | Accelerate | | HL | 18505922 |
| Sen_G_0210 | DEK | 7913 | -- | -- | Unclear | -- | -- | protein coding | HeLa | -- | Aging | Prevent | | HL | 16254365 |
| Sen_G_0211 | ACACA | 31 | P38MAPK | -- | Unclear | -- | -- | protein coding | Human primary Fibroblast | -- | Aging | Prevent | | L | 27983949 |
| Sen_G_0212 | S100A6 | 6277 | CDK1 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | HL | 23095053 |
| Sen_G_0213 | CARM1 | 10498 | SIRT1//P53 | --//-- | Unclear | -- | -- | protein coding | Human bronchial epithelial cell | -- | Chronic obstructive pulmonary disease | Prevent | | HL | 31461302 |
| Sen_G_0214 | KDM3A | 55818 | -- | -- | Unclear | -- | -- | protein coding | OVCAR-5,A2780 | -- | Ovarian cancer | Prevent | | HL | 27694900 |
| Sen_G_0215 | CLU | 1191 | ATM | -- | Unclear | IGF-1R-MAPK-ERK1/2-EGR-1 | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 24937130 |
| Sen_G_0216 | ING1 | 3621 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Accelerate | | L | 15601862 |
| Sen_G_0217 | SFRP1 | 6422 | -- | -- | Unclear | WNT | Downregulation | protein coding | CSC | -- | Aging | Accelerate | | L | 28435069 |
| Sen_G_0218 | TP53 | 7157 | P21 | Upregulation | Unclear | -- | -- | protein coding | PCI-13 | -- | Squamous cell carcinoma | Accelerate | | L | 25766317 |
| Sen_G_0219 | NDRG1 | 10397 | -- | -- | Unclear | GSK3β-P53/-P16 | -- | protein coding | HepG2 | -- | Hepatocellular carcinoma | Prevent | | HL | 24302615 |
| Sen_G_0220 | RB1 | 5925 | P53//P27//P21 | --//--//-- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Prevent | | HL | 23370776 |
| Sen_G_0221 | KIR2DL4 | 3805 | -- | -- | Unclear | -- | -- | protein coding | NK | -- | Aging | Accelerate | | HL | 23184984 |
| Sen_G_0222 | NOX4 | 50507 | -- | -- | Unclear | -- | -- | protein coding | MCF12A | -- | Breast cancer | Accelerate | | HL | 20523116 |
| Sen_G_0223 | TNF | 7124 | P16 | Upregulation | Unclear | P38 MAPK | Activation | protein coding | EPC | -- | Aging | Accelerate | | L | 19124561 |
| Sen_G_0224 | MDM2 | 4193 | HMGA2 | -- | Unclear | -- | -- | protein coding | Adipose stromal cell | -- | Aging | Prevent | | L | 21456046 |
| Sen_G_0225 | CCL2 | 6347 | CCR2 | -- | Unclear | ROS-P38-MAPK-P53-P21 | Activation | protein coding | UCB-MSC | -- | Aging | Accelerate | | HL | 26573462 |
| Sen_G_0226 | CCR2 | 729230 | BMI1 | Downregulation | Unclear | P53-P21 | Activation | protein coding | UCB-MSC | -- | Aging | Accelerate | | HL | 26573462 |
| Sen_G_0227 | BMI1 | 648 | MCP-1 | -- | Unclear | P53-P21 | -- | protein coding | UCB-MSC | -- | Aging | Prevent | | HL | 26573462 |
| Sen_G_0228 | RBP2 | 5948 | P16//P21//P27 | --//--//-- | Unclear | -- | -- | protein coding | AGS,HeLa,SiHa,HGC-27,BGC-823 | -- | Gastric cancer | Prevent | | L | 19850045 |
| Sen_G_0229 | PIM1 | 5292 | HBP1 | Upregulation | Phosphorylation | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | | HL | 28348080 |
| Sen_G_0230 | SIRT1 | 23411 | CDK5 | -- | Unclear | -- | -- | protein coding | PAEC | -- | Atherosclerosis | Prevent | | HL | 22753194 |
| Sen_G_0231 | OTX2 | 5015 | IL-6//IGFBP7 | Upregulation//Upregulation | Binding to promoter | P53 | Activation | protein coding | Daoy ,MED8A | -- | Medulloblastoma | Accelerate | | HL | 21047732 |
| Sen_G_0232 | ZEB1 | 6935 | P15INK4B//P16 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | EPC1-hTERT | -- | Endometrial cancer | Prevent | | L | 20424117 |
| Sen_G_0233 | ZEB2 | 9839 | P15INK4B//P16 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | EPC2-hTERT | -- | Endometrial cancer | Prevent | | L | 20424117 |
| Sen_G_0234 | EGFR | 1956 | -- | -- | Unclear | -- | -- | protein coding | EPC2-hTERT | -- | Endometrial cancer | Accelerate | | L | 20424117 |
| Sen_G_0235 | PPARGC1A | 10891 | HDAC1//SIRT1 | --//-- | Unclear | -- | -- | protein coding | HBMVEC | -- | Aging | Prevent | | L | 30016403 |
| Sen_G_0236 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | iCSCL-10A | -- | Cancer | Accelerate | | HL | 23318426 |
| Sen_G_0237 | MCRS1 | 10445 | BRG1 | -- | Unclear | P53-P21 | Activation | protein coding | IMR-90,Hs68 | -- | Aging | Accelerate | | L | 22563078 |
| Sen_G_0238 | EID3 | 493861 | P21//P57 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | MCF-7 | -- | Breast cancer | Accelerate | | HL | 30114644 |
| Sen_G_0239 | CHD5 | 26038 | -- | -- | Unclear | -- | -- | protein coding | HepG2,Hep3B | -- | Hepatocellular carcinoma | Accelerate | | HL | 24529164 |
| Sen_G_0240 | BCL11B | 64919 | P21//P53//SOX2//BMI-1 | --//--//--//-- | Unclear | -- | -- | protein coding | U87,U251 | -- | Glioma | Prevent | | L | 26096706 |
| Sen_G_0241 | SIRT6 | 51548 | γH2AX//TIFS//P16//P21 | --//--//--//-- | Unclear | -- | -- | protein coding | NHAC-kn | -- | Aging | Prevent | | L | 25819580 |
| Sen_G_0242 | CREB1 | 1385 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | HL | 23991634 |
| Sen_G_0243 | CDCA3 | 83461 | P21 | -- | Unclear | -- | -- | protein coding | HBEC3,HBEC4,HBEC5,H2228,H460,SKMES-1,EBC-1,HTB-182,CRL-5889,A549 | -- | Lung cancer | Prevent | | HL | 28487093 |
| Sen_G_0244 | DNMT1 | 1786 | UHRF1//WNT5A | --//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | HL | 28100769 |
| Sen_G_0245 | UHRF1 | 29128 | DNMT1//WNT5A | Inhibition//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | HL | 28100769 |
| Sen_G_0246 | XPG | 17295032 | -- | -- | Unclear | -- | -- | protein coding | Embryonic Fibroblast | -- | Aging | Prevent | | L | 10022922 |
| Sen_G_0247 | ZNF148 | 7707 | P16 | Downregulation | Binding to promoter | -- | -- | protein coding | NCI-H460 | -- | Lung cancer | Prevent | | L | 19583777 |
| Sen_G_0248 | HDAC1 | 3065 | P21 | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | L | 16250917 |
| Sen_G_0249 | CD59 | 966 | -- | -- | Unclear | -- | -- | protein coding | ECA-109 | -- | Aging | Prevent | | L | 30166523 |
| Sen_G_0250 | PTTG1 | 9232 | P21 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | L | 21858218 |
| Sen_G_0251 | GAPDH | 2597 | AMPK//P53 | --//-- | Unclear | -- | -- | protein coding | A549 | -- | Lung cancer | Prevent | | HL | 21749859 |
| Sen_G_0252 | ABI3 | 51225 | P21//E2F1 | Upregulation//Downregulation | Phosphorylation | -- | -- | protein coding | ARO,WRO | -- | Aging | Accelerate | | L | 21223585 |
| Sen_G_0253 | EHF | 26298 | P16//P27 | --//-- | Unclear | -- | -- | protein coding | MEF | -- | Prostate cancer | Prevent | | L | 17172423 |
| Sen_G_0254 | LMNA | 4000 | P53 | -- | Unclear | -- | -- | protein coding | VSMC,HUVEC | -- | Hutchinson-Gilford progeria syndrome | Accelerate | | HL | 28423660 |
| Sen_G_0255 | RHOA | 387 | -- | -- | Unclear | -- | -- | protein coding | HeLa | -- | Aging | Prevent | | L | 26649141 |
| Sen_G_0256 | BRG1 | 834543 | BRCA1//P16//P21 | --//Upregulation//Upregulation | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 23438604 |
| Sen_G_0257 | ING1 | 3621 | ITSN2 | Upregulation | Unclear | RB-E2F | -- | protein coding | Fibroblast | -- | Aging | Accelerate | | HL | 23472054 |
| Sen_G_0258 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | HepG2 | -- | Hepatocellular carcinoma | Prevent | | L | 23339189 |
| Sen_G_0259 | XRCC4 | 7518 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Prevent | | L | 27391797 |
| Sen_G_0260 | LIG4 | 3981 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Prevent | | L | 27391797 |
| Sen_G_0261 | TACC3 | 10460 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 20729911 |
| Sen_G_0262 | PTEN | 5728 | -- | -- | Unclear | -- | -- | protein coding | -- | Prostate | Prostate cancer | Prevent | | HL | 19690330 |
| Sen_G_0263 | AKT1 | 207 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | Human endothelial cell | -- | Aging | Accelerate | | L | 14713953 |
| Sen_G_0264 | TAZ | 6901 | -- | -- | Unclear | WNT | Downregulation | protein coding | LN-229 | -- | Glioblastoma | Prevent | | HL | 30542117 |
| Sen_G_0265 | NNT | 23530 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Prevent | | L | 27428041 |
| Sen_G_0266 | NMNAT3 | 349565 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Prevent | | L | 27428041 |
| Sen_G_0267 | MUS81 | 80198 | -- | -- | Unclear | -- | -- | protein coding | SKOV3,A2780 | -- | Ovarian cancer | Prevent | | L | 27255997 |
| Sen_G_0268 | ATRAID | 51374 | -- | -- | Unclear | -- | -- | protein coding | ARPE?19 | -- | Aging | Accelerate | | L | 26934949 |
| Sen_G_0269 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Systemic Lupus Erythematosus | Accelerate | | L | 22820504 |
| Sen_G_0270 | CDKN2A | 1029 | CDK4//CDK6 | Downregulation//Downregulation | Unclear | -- | -- | protein coding | Human WMM1175 melanoma cell | -- | Melanoma | Accelerate | | L | 18843795 |
| Sen_G_0271 | DNMT1 | 1786 | ZEB1 | Upregulation | Binding to promoter Methylation | -- | -- | protein coding | HDF | -- | Aging | Prevent | | HL | 29466247 |
| Sen_G_0272 | FOXA1 | 3169 | P16 | Activation | Unclear | AKT | Downregulation | protein coding | HEC-1B | -- | Endometrial cancer | Accelerate | | L | 27349269 |
| Sen_G_0273 | RAC3 | 5881 | -- | -- | Unclear | -- | -- | protein coding | HEK293 | -- | Aging | Prevent | | L | 26469953 |
| Sen_G_0274 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 27980070 |
| Sen_G_0275 | ARHGAP18 | 93663 | AP1 | -- | Unclear | NF-κB | Upregulation | protein coding | HUVEC | -- | Aging | Accelerate | | L | 25407919 |
| Sen_G_0276 | PPARD | 5467 | SIRT1 | Upregulation | Unclear | -- | -- | protein coding | HCAEC | -- | Aging | Prevent | | L | 23000914 |
| Sen_G_0277 | SIRT1 | 23411 | FOXO3α//P53 | --//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | L | 25165029 |
| Sen_G_0278 | CDKN2A | 1029 | -- | -- | Unclear | NF-κB | Upregulation | protein coding | CPC | -- | Aging | Accelerate | | L | 29675777 |
| Sen_G_0279 | STIM1 | 6786 | -- | -- | Unclear | -- | -- | protein coding | PC-3,DU 145 | -- | Prostate cancer | Accelerate | | HL | 26257076 |
| Sen_G_0280 | RTN4 | 57142 | -- | -- | Unclear | -- | -- | protein coding | DU 145 | -- | Prostate cancer | Accelerate | | L | 30480803 |
| Sen_G_0281 | YY1 | 7528 | P16 | Downregulation | Acetylation | -- | -- | protein coding | H460 | -- | Aging | Prevent | | L | 18558095 |
| Sen_G_0282 | PIM1 | 5292 | CBX8 | Downregulation | Unclear | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 29763603 |
| Sen_G_0283 | GLIS2 | 84662 | -- | -- | Unclear | -- | -- | protein coding | -- | Kidney | Aging | Prevent | | L | 27181777 |
| Sen_G_0284 | HTRA1 | 5654 | -- | -- | Unclear | P38 MAPK | Activation | protein coding | ARPE-19 | -- | Aging | Accelerate | | L | 23623979 |
| Sen_G_0285 | MAML1 | 9794 | STAT1 | -- | Unclear | -- | -- | protein coding | B16 | -- | Melanoma | Prevent | | L | 22864395 |
| Sen_G_0286 | MCL1 | 4170 | -- | -- | Unclear | PI3K-AKT | Downregulation | protein coding | Human glioma cell | -- | Glioma | Prevent | | L | 30296359 |
| Sen_G_0287 | PINK1 | 65018 | PARKIN | -- | Unclear | -- | -- | protein coding | NPC | -- | Aging | Prevent | | L | 29890141 |
| Sen_G_0288 | CABLES1 | 91768 | -- | -- | Unclear | P21 | Upregulation | protein coding | HUVEC | -- | Aging | Accelerate | | L | 28118639 |
| Sen_G_0289 | SIRT1 | 23411 | -- | -- | Unclear | P53-P21 | Downregulation | protein coding | CEP | -- | Disc degenerative disease | Prevent | | L | 26940203 |
| Sen_G_0290 | COX5B | 1329 | -- | -- | Unclear | -- | -- | protein coding | MDA-MB-231,MDA-MB-468,MCF-7 | -- | Breast cancer | Prevent | | L | 26506233 |
| Sen_G_0291 | ARID1A | 8289 | P16 | Upregulation | Unclear | -- | -- | protein coding | HPNE | -- | Pancreatic cancer | Accelerate | | L | 28942143 |
| Sen_G_0292 | EZH2 | 2146 | P53 | -- | Unclear | -- | -- | protein coding | MKN28 | -- | Gastric cancer | Prevent | | L | 24738879 |
| Sen_G_0293 | SREBF1 | 6720 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | L | 20615871 |
| Sen_G_0294 | GRPR | 2925 | EGFR//P38//P16//P21 | --//--//--//-- | Unclear | P53 | -- | protein coding | A172 | -- | Glioblastoma | Prevent | | L | 26780458 |
| Sen_G_0295 | CPEB1 | 64506 | MIR-101//P53 | --//-- | Unclear | -- | -- | protein coding | U87,U251 | -- | Glioma | Prevent | | L | 23788032 |
| Sen_G_0296 | NRSN2 | 80023 | BCL-2 | -- | Unclear | PI3K-AKT-MTOR//P53-P21 | --//-- | protein coding | SMMC-7721 | -- | Hepatocellular carcinoma | Accelerate | | L | 26055238 |
| Sen_G_0297 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | iPSC-Ecs | -- | Aging | Prevent | | L | 26413932 |
| Sen_G_0298 | HRH4 | 59340 | -- | -- | Unclear | -- | -- | protein coding | MDA-MB-231,MCF-7 | -- | Breast cancer | Accelerate | | L | 21622113 |
| Sen_G_0299 | CDKN1A | 1026 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 16243918 |
| Sen_G_0300 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 16243918 |
| Sen_G_0301 | HIF1A | 3091 | -- | -- | Unclear | -- | -- | protein coding | SH-SY5Y,SKNBE2c,SKNAS | -- | Neuroblastoma | Prevent | | HL | 26057707 |
| Sen_G_0302 | EPAS1 | 2034 | -- | -- | Unclear | -- | -- | protein coding | SH-SY5Y,SKNBE2c,SKNAS | -- | Neuroblastoma | Prevent | | HL | 26057707 |
| Sen_G_0303 | NOTCH1 | 4851 | -- | -- | Unclear | ID-1-P16 | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 24950189 |
| Sen_G_0304 | ROC1 | 830029 | -- | -- | Unclear | -- | -- | protein coding | HuH-7,HepG2,LM 6 | -- | Liver cancer | Prevent | | L | 22935614 |
| Sen_G_0305 | PRKD2 | 25865 | -- | -- | Phosphorylation Unclear | P53 | -- | protein coding | U87,GM133 | -- | Glioblastoma | Prevent | | L | 24463355 |
| Sen_G_0306 | XRCC3 | 7517 | -- | -- | Unclear | -- | -- | protein coding | NIH-3T3 | -- | Hypertension-induced left ventricular hypertrophy | Prevent | | L | 29626209 |
| Sen_G_0307 | SYT7 | 9066 | P16//P21//P53 | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | H23 | -- | Lung cancer | Prevent | | L | 30647108 |
| Sen_G_0308 | PAK4 | 10298 | P21 | Downregulation | Unclear | -- | -- | protein coding | U87 MG,LN-18 | -- | Glioblastoma | Prevent | | L | 26297735 |
| Sen_G_0309 | DPP4 | 1803 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 28877934 |
| Sen_G_0310 | LRP8 | 7804 | CDC20-PP2A | -- | Unclear | -- | -- | protein coding | Smooth muscle cell | -- | Cardiovascular disease | Prevent | | L | 31412739 |
| Sen_G_0311 | CCNB1 | 891 | BAX//CASPASE‐9//CASPASE‐3//P21 | Downregulation//Downregulation//Downregulation//Downregulation | Unclear | P53 | Downregulation | protein coding | Capan‐2 PC,PC primary cell | -- | Pancreatic cancer | Prevent | | L | 30069972 |
| Sen_G_0312 | DEK | 7913 | NF-κBP65 | Upregulation | Unclear | -- | -- | protein coding | CaSki | -- | Cervical cancer | Prevent | | L | 22390170 |
| Sen_G_0313 | HES1 | 3280 | -- | -- | Phosphorylation Unclear | STAT3-MMP14 | -- | protein coding | Caco-2,SW48 | -- | Colorectal cancer | Prevent | | L | 26650241 |
| Sen_G_0314 | STAT5A | 100135887 | -- | -- | Unclear | JAK-STAT5//P53 | Activation//Activation | protein coding | MEF | -- | Aging | Accelerate | | HL | 20536843 |
| Sen_G_0315 | HGF | 3082 | RAC1//PIP3//AKT | --//Downregulation//-- | Unclear | -- | -- | protein coding | EPC | -- | Aging | Prevent | | L | 19047582 |
| Sen_G_0316 | CBS | 875 | -- | -- | Unclear | -- | -- | protein coding | HUVEC,HAEC,HDF | -- | Aging | Prevent | | L | 23117410 |
| Sen_G_0317 | HMGA2 | 8091 | P16//P21 | --//-- | Unclear | AKT | -- | protein coding | ULM | -- | Uterine leiomyomas | Prevent | | HL | 29790226 |
| Sen_G_0318 | GNAO1 | 2775 | -- | -- | Unclear | -- | -- | protein coding | GY-7703,SMMC-7721 | -- | Hepatocellular carcinoma | Accelerate | | L | 23984917 |
| Sen_G_0319 | BRG1 | 834543 | P21/WAF1/SDI | Upregulation | Phosphorylation | -- | -- | protein coding | SW 13 | -- | Retinoblastoma | Accelerate | | L | 14729964 |
| Sen_G_0320 | FOXO1 | 2308 | SIRT1//P16 | Downregulation//Upregulation | Unclear | -- | -- | protein coding | T98G,LN-18 | -- | Glioblastoma | Accelerate | | L | 29207098 |
| Sen_G_0321 | FOXO4 | 4303 | BRAFV600E//P21 | -- | Unclear | -- | -- | protein coding | COLO 829 | -- | Melanoma | Accelerate | | L | 20959475 |
| Sen_G_0322 | BMI1 | 648 | P16//P14 | Downregulation//Downregulation | Unclear | -- | -- | protein coding | GIST882 | -- | Gastrointestinal stromal tumor | Prevent | | L | 29042141 |
| Sen_G_0323 | MEOX1 | 4222 | P21/WAF1//P16 | Activation//Activation | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 22206000 |
| Sen_G_0324 | MEOX2 | 4223 | P21/WAF1//P16INK5A | Activation//Activation | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 22206000 |
| Sen_G_0325 | ATM | 472 | -- | -- | Phosphorylation | ATM-AKT-P53-P21 | Activation | protein coding | HUVEC | -- | Aging | Accelerate | | L | 20639198 |
| Sen_G_0326 | ADIPOQ | 9370 | CXCL1 | Upregulation | Unclear | P53//P16 | Activation//Activation | protein coding | -- | Liver | Tumor | Accelerate | | HL | 27092462 |
| Sen_G_0327 | ATF3 | 467 | P53 | Downregulation | Unclear | -- | -- | protein coding | HKC,SCC | -- | Skin cancer | Prevent | | HL | 20485437 |
| Sen_G_0328 | RCC1 | 1104 | -- | -- | Unclear | -- | -- | protein coding | hTERT-RPE1 | -- | Aging | Prevent | | L | 26864624 |
| Sen_G_0329 | PSMB5 | 5693 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | -- | Aging | Prevent | | L | 24393841 |
| Sen_G_0330 | TBX2 | 6909 | NDRG1 | Downregulation | Binding to promoter | -- | -- | protein coding | MCF-7 | -- | Breast cancer | Prevent | | HL | 20348948 |
| Sen_G_0331 | ZEB1 | 6935 | DDK1//MUTANT P53//MDM2//CTBP//MACROH2A1 | Activation//Activation//Activation//Activation//Downregulation | Unclear | -- | -- | protein coding | SW480 | -- | Colorectal cancer | Prevent | | HL | 27965283 |
| Sen_G_0332 | THRB | 7068 | P21//P16//RB | Upregulation//Upregulation//Downregulation | Unclear | -- | -- | protein coding | ARO,MCF-7,COS-7 | -- | Aging | Accelerate | | L | 17965546 |
| Sen_G_0333 | H1-3 | 3007 | P53//P21//RB | --//Upregulation//-- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 17158953 |
| Sen_G_0334 | TGFB1 | 7040 | MIR-29//H4K20ME3 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 29967491 |
| Sen_G_0335 | DGCR8 | 54487 | P21 | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Colorectal cancer | Prevent | | HL | 23773483 |
| Sen_G_0336 | HOPX | 84525 | -- | -- | Unclear | RAS-MAPK//AKT | Activation//Downregulation | protein coding | HBEC,Y-BE | -- | Lung cancer | Accelerate | | HL | 25345926 |
| Sen_G_0337 | BHLHE40 | 8553 | -- | -- | Unclear | -- | -- | protein coding | HEK293,EC9706 | -- | Endometrial cancer | Accelerate | | HL | 22844531 |
| Sen_G_0338 | SIRT6 | 51548 | -- | -- | Unclear | IGF-AKT-MTOR | Downregulation | protein coding | HBEC | -- | Lung cancer | Prevent | | L | 24367027 |
| Sen_G_0339 | GADD45G | 10912 | -- | -- | Unclear | JAK-STAT3 | Downregulation | protein coding | SK-Hep-1,Hep3B,SMMC-7721 | -- | Hepatocellular carcinoma | Accelerate | | HL | 23897841 |
| Sen_G_0340 | PRKN | 5071 | -- | -- | Unclear | -- | -- | protein coding | Airway epithelial cell | Lung | Chronic obstructive pulmonary disease | Prevent | | L | 30290714 |
| Sen_G_0341 | CD40L | 100286596 | -- | -- | Unclear | ATM-CHK2 | -- | protein coding | A549,H460 | -- | Lung cancer | Prevent | | L | 29565449 |
| Sen_G_0342 | FOXO3 | 2309 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 26873092 |
| Sen_G_0343 | KNDC1 | 85442 | -- | -- | Unclear | P53-P21-P16 | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 24788352 |
| Sen_G_0344 | HDAC2 | 3066 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | HL | 17409421 |
| Sen_G_0345 | DAO | 1610 | -- | -- | Unclear | -- | -- | protein coding | U2OS,HepG2 | -- | Aging | Accelerate | | L | 30659069 |
| Sen_G_0346 | SIRT7 | 51547 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | L | 29728458 |
| Sen_G_0347 | DPY30 | 84661 | ID | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 23872946 |
| Sen_G_0348 | HRAS | 3265 | P53 | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Accelerate | | L | 30526305 |
| Sen_G_0349 | HSP27 | 39078 | E2F4//P130 | --//-- | Unclear | -- | -- | protein coding | MRC-5 | -- | Aging | Prevent | | L | 30166342 |
| Sen_G_0350 | XAF1 | 54739 | -- | -- | Unclear | P53 | -- | protein coding | HMVEC | -- | Aging | Accelerate | | L | 26802028 |
| Sen_G_0351 | IGFBP4 | 3487 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Accelerate | | L | 24201810 |
| Sen_G_0352 | IGFBP7 | 3490 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Accelerate | | L | 24201810 |
| Sen_G_0353 | ABI3BP | 25890 | -- | -- | Unclear | P21 | Upregulation | protein coding | ARO | -- | Aging | Accelerate | | L | 18559958 |
| Sen_G_0354 | PIM1 | 5292 | -- | -- | Unclear | P53-P21 | Activation | protein coding | 22Rv1 | -- | Aging | Accelerate | | L | 20647331 |
| Sen_G_0355 | HEPACAM | 220296 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 18845560 |
| Sen_G_0356 | LSD1 | 827786 | H3K9ME2 | Inhibition | Methylation | -- | -- | protein coding | PC-3 | -- | Aging | Prevent | | HL | 28991226 |
| Sen_G_0357 | DICER1 | 23405 | -- | -- | Unclear | -- | -- | protein coding | WI-38,IMR-90 | -- | Aging | Prevent | | HL | 26990999 |
| Sen_G_0358 | HDAC9 | 9734 | MIR-31 | -- | Unclear | -- | -- | protein coding | MRC-5 | -- | Aging | Prevent | Others | HL | 25737447 |
| Sen_G_0359 | PPARD | 5467 | PTEN | Upregulation | Unclear | PI3K-AKT | -- | protein coding | VSMC | -- | Aging | Prevent | | L | 22072715 |
| Sen_G_0360 | GLO1 | 2739 | -- | -- | Unclear | -- | -- | protein coding | RPTEC | -- | Aging | Prevent | | L | 22001178 |
| Sen_G_0361 | HDAC1 | 3065 | -- | -- | Unclear | -- | -- | protein coding | UCD-Mel-J | -- | Aging | Accelerate | | L | 17578512 |
| Sen_G_0362 | RAD21 | 5885 | C-MYC | -- | Unclear | RB-E2F | -- | protein coding | MDA-MB-231,HCT116,LNCaP,DU 145 | -- | Aging | Prevent | | L | 26529363 |
| Sen_G_0363 | XRCC5 | 7520 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 30616437 |
| Sen_G_0364 | PTGES2 | 10728 | EP3 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 24046862 |
| Sen_G_0365 | SIRT1 | 23411 | P53 | -- | Unclear | -- | -- | protein coding | BOEC | Peripheral Blood | Chronic obstructive pulmonary disease | Prevent | | L | 23897750 |
| Sen_G_0366 | ATM | 472 | SIRT1 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Chronic obstructive pulmonary disease | Accelerate | | L | 23897750 |
| Sen_G_0367 | CKB | 1152 | -- | -- | Unclear | -- | -- | protein coding | HBEC | -- | Aging | Prevent | | L | 21980054 |
| Sen_G_0368 | MKRN1 | 23608 | P14 | -- | Unclear | -- | -- | protein coding | AGS,SNU601,MEF | -- | Gastric cancer | Prevent | | HL | 23104211 |
| Sen_G_0369 | CBX7 | 23492 | P16 | -- | Unclear | -- | -- | protein coding | SGC-7901 | -- | Gastric cancer | Prevent | | L | 20723236 |
| Sen_G_0370 | SYK | 6850 | -- | -- | Unclear | P53-P21//PRB | Upregulation//Upregulation | protein coding | A375 | -- | Melanoma | Accelerate | | L | 19293188 |
| Sen_G_0371 | FBXO31 | 79791 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Breast cancer | Accelerate | | L | 16357137 |
| Sen_G_0372 | PRC2 | 3647044 | INK4A | -- | Unclear | -- | -- | protein coding | TIG-3 | -- | Aging | Prevent | | HL | 17344414 |
| Sen_G_0373 | TNF | 7124 | HSA-MIR-20B | Upregulation | Unclear | -- | -- | protein coding | HMVEC | -- | Aging | Accelerate | | HL | 28595801 |
| Sen_G_0374 | DIP2C | 22982 | -- | -- | Unclear | -- | -- | protein coding | RKO | -- | Colorectal cancer | Prevent | | HL | 28716088 |
| Sen_G_0375 | ASF1A | 25842 | -- | -- | Unclear | P53-P21 | -- | protein coding | HepG2,LNCaP | -- | Aging | Prevent | | L | 30692519 |
| Sen_G_0376 | OPTN | 10133 | -- | -- | Unclear | -- | -- | protein coding | RTEC | Kidney | Aging | Prevent | | L | 29367621 |
| Sen_G_0377 | POLB | 5423 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | | L | 29968395 |
| Sen_G_0378 | CARF | 79800 | -- | -- | Unclear | P53 | Activation | protein coding | Fibroblast | -- | Aging | Accelerate | | L | 19001376 |
| Sen_G_0379 | CD40LG | 959 | -- | -- | Unclear | NF-κB | -- | protein coding | A549,H460 | -- | Lung cancer | Prevent | | L | 30078020 |
| Sen_G_0380 | NSUN2 | 54888 | SHC | Upregulation | Methylation | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | HL | 26992231 |
| Sen_G_0381 | MEF2A | 4205 | MIR-143 | Upregulation | Unclear | -- | -- | protein coding | VSMC | -- | Aging | Accelerate | | L | 25655189 |
| Sen_G_0382 | CCN2 | 1490 | -- | -- | Unclear | -- | -- | protein coding | Human airway epithelial cell | -- | Aging | Accelerate | | L | 28026993 |
| Sen_G_0383 | NR0B2 | 8431 | P16//PRB | Downregulation//Upregulation | Unclear | -- | -- | protein coding | CNE-1,CNE-2 | -- | Nasopharyngeal carcinoma | Prevent | | L | 26215037 |
| Sen_G_0384 | WNT9A | 7483 | -- | -- | Unclear | -- | -- | protein coding | Mouse renal tubular cell | Kidney | Aging | Accelerate | | L | 29440280 |
| Sen_G_0385 | IFNG | 3458 | NOX4//ANT2 | --//Downregulation | Unclear | TGFβ-SMAD | Activation | protein coding | HeLa | -- | Aging | Accelerate | | L | 25982278 |
| Sen_G_0386 | RNF114 | 55905 | P21 | -- | Unclear | -- | -- | protein coding | MEF,IMR-90,MCF-7 | -- | Aging | Prevent | | L | 23645206 |
| Sen_G_0387 | CSNK2A1 | 1457 | -- | -- | Unclear | PI3K-AKT-MTOR-ROS | -- | protein coding | HCT116 | -- | Aging | Prevent | | L | 23523798 |
| Sen_G_0388 | IFNB1 | 3456 | PML//P21//P53 | Upregulation//Upregulation//Activation | Acetylation Phosphorylation | -- | -- | protein coding | LXSN,K16,K38,ME-180,Caski,HeLa,SiHa | -- | Aging | Accelerate | | HL | 22615843 |
| Sen_G_0389 | POU5F1 | 5460 | P21 | Downregulation | Unclear | -- | -- | protein coding | PA-1 | -- | Embryonal carcinoma | Accelerate | | L | 26102294 |
| Sen_G_0390 | KRAS | 3845 | TP53 | -- | Unclear | -- | -- | protein coding | -- | Gills,bone,skin,gut,liver,heart,brain | Aging | Accelerate | | L | 19132118 |
| Sen_G_0391 | PPARD | 5467 | PTEN | Upregulation | Unclear | PI3K-AKT-RAC1 | Downregulation | protein coding | Human primary keratinocyte | -- | Aging | Prevent | | L | 22335598 |
| Sen_G_0392 | MYC | 4609 | INK4A//P21//P53//IL-6 | --//--//--//-- | Unclear | -- | -- | protein coding | -- | Pancreas | Aging | Accelerate | | L | 29280266 |
| Sen_G_0393 | HRAS | 3265 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 28247536 |
| Sen_G_0394 | G6PD | 2539 | -- | -- | Unclear | -- | -- | protein coding | HFF-3,HFF-1 | -- | Aging | Prevent | | L | 14980702 |
| Sen_G_0395 | PML | 5371 | P53 | Upregulation | Acetylation | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 10910364 |
| Sen_G_0396 | TP53BP2 | 7159 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 22847423 |
| Sen_G_0397 | STMN1 | 3925 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 28885720 |
| Sen_G_0398 | IL1RN | 3557 | -- | -- | Unclear | -- | -- | protein coding | MEF,Primary MEF,LNCaP | -- | Cancer | Prevent | | HL | 25156255 |
| Sen_G_0399 | PGR | 5241 | P21//FOXO1 | Upregulation//-- | Unclear | -- | -- | protein coding | ES‐2 | -- | Ovarian cancer | Accelerate | | HL | 23574718 |
| Sen_G_0400 | YAP1 | 10413 | -- | -- | Unclear | ERK//BCL-2 | Upregulation//Downregulation | protein coding | PDLSC | -- | Aging | Prevent | | L | 29104479 |
| Sen_G_0401 | WIF1 | 11197 | P53//P21 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | PA116,CaExPA79 | Primary salivary gland tumor | Salivary gland tumor | Accelerate | | L | 24853424 |
| Sen_G_0402 | MUC4 | 4585 | -- | -- | Unclear | P16-RB | -- | protein coding | UMSCC10B,UMSCC1 | -- | Squamous cell carcinoma | Prevent | | L | 24747969 |
| Sen_G_0403 | NOL12 | 79159 | -- | -- | Unclear | P53 | -- | protein coding | HDF | Skin | Aging | Prevent | | L | 30988155 |
| Sen_G_0404 | MEOX2 | 4223 | INK4A | Upregulation | Binding to promoter | -- | -- | protein coding | IMR-90,WI-38,HEKn | -- | Aging | Accelerate | | L | 19340300 |
| Sen_G_0405 | ERCC6 | 2074 | P21 | Downregulation | Binding to promoter | DDR-P21 | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 31811121 |
| Sen_G_0406 | SPOP | 8405 | SENP7//HP1α | Downregulation//-- | Unclear | -- | -- | protein coding | IMR-90 | -- | Prostate cancer | Accelerate | | L | 26527005 |
| Sen_G_0407 | SRSF1 | 6426 | RPL5//P53 | --//-- | Unclear | -- | -- | protein coding | Primary Fibroblast | -- | Aging | Accelerate | | L | 23478443 |
| Sen_G_0408 | NOLC1 | 9221 | CSIG | -- | Unclear | -- | -- | protein coding | 2BS | -- | Hepatocellular carcinoma | Accelerate | | HL | 28493459 |
| Sen_G_0409 | HDAC1 | 3065 | -- | -- | Unclear | SP1-PP2A-PRB | -- | protein coding | HeLa | -- | Cervical cancer | Accelerate | | L | 21420382 |
| Sen_G_0410 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | RPE | -- | Aging | Prevent | | L | 9454332 |
| Sen_G_0411 | HELLS | 3070 | P16//HDAC | Inhibition//-- | Acetylation | -- | -- | protein coding | 2BS,WI-38 | -- | Aging | Prevent | | L | 19561196 |
| Sen_G_0412 | TERF2 | 7014 | P53 | -- | Unclear | -- | -- | protein coding | U2OS | -- | Aging | Prevent | | L | 18056407 |
| Sen_G_0413 | PML | 5371 | E2F//P53 | Downregulation//-- | Binding to promoter | -- | -- | protein coding | IMR-90 | -- | Prostate cancer | Accelerate | | HL | 21205865 |
| Sen_G_0414 | TPR | 7175 | -- | -- | Unclear | P53 | -- | protein coding | HeLa | -- | Cancer | Prevent | | L | 21811608 |
| Sen_G_0415 | USP1 | 7398 | KDM4A | -- | Unclear | -- | -- | protein coding | WI-38,BJ | -- | Aging | Prevent | | HL | 27160904 |
| Sen_G_0416 | NEDD4 | 4734 | PPARγ | Downregulation | Unclear | -- | -- | protein coding | IMR-90,2BS | -- | Aging | Prevent | | L | 23549616 |
| Sen_G_0417 | UBC | 7316 | HUB | -- | Unclear | -- | -- | protein coding | BM-MSC | -- | Aging | Prevent | | HL | 29382826 |
| Sen_G_0418 | PML | 5371 | PML/RARα//P53//P16//P21 | --//--//--//-- | Unclear | -- | -- | protein coding | MRC-5,WI-38 | -- | Aging | Prevent | | L | 26119943 |
| Sen_G_0419 | MET | 4233 | -- | -- | Unclear | -- | -- | protein coding | MDCK epithelial cell | -- | Tumor | Accelerate | | L | 17588532 |
| Sen_G_0420 | PRKCA | 5578 | -- | -- | Unclear | AKT-FOXO3A-ROS-P53-P21 | -- | protein coding | HEK293,HCT116 | -- | Aging | Prevent | | L | 28989024 |
| Sen_G_0421 | SIRT6 | 51548 | WRN | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Prevent | | L | 18337721 |
| Sen_G_0422 | PML | 5371 | -- | -- | Unclear | RB | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 14712214 |
| Sen_G_0423 | HMGB1 | 3146 | P53//NF-κB | --//-- | Unclear | -- | -- | protein coding | IMR-90,HCA2,HMEC,MEF | Embryo | Aging | Prevent | | L | 23649808 |
| Sen_G_0424 | CCN1 | 3491 | P53//NOX1//P38MAPK//ERK | Activation//Upregulation//Activation//Activation | Unclear | P16-PRB//INTEGRIN | --//-- | protein coding | BJ | -- | Aging | Accelerate | | L | 20526329 |
| Sen_G_0425 | TLR2 | 7097 | P21//P16//P15INK4B//P53 | --//--//--//-- | Unclear | NF-κB//P38 MAPK//A-SAA | --//--//-- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 31183403 |
| Sen_G_0426 | GOT2 | 2806 | P27 | -- | Unclear | -- | -- | protein coding | 8988T | -- | Pancreatic ductal adenocarcinoma | Prevent | | L | 29352139 |
| Sen_G_0427 | PDGFB | 5155 | P53 | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | L | 23934686 |
| Sen_G_0428 | AR | 367 | P53//P21//P63//RB | --//Upregulation//Downregulation//-- | Phosphorylation | -- | -- | protein coding | PC-3 | -- | Prostate cancer | Accelerate | | L | 22403609 |
| Sen_G_0429 | PINK1 | 65018 | -- | -- | Unclear | -- | -- | protein coding | HBEC | Lung | Aging | Prevent | | L | 25714760 |
| Sen_G_0430 | PRKN | 5071 | -- | -- | Unclear | -- | -- | protein coding | HBEC | Lung | Aging | Prevent | | L | 25714760 |
| Sen_G_0431 | HAS2 | 3037 | -- | -- | Unclear | P27-CDK2-SKP2 | -- | protein coding | Fibroblast | Lung | Lung fibrosis | Prevent | | L | 26987798 |
| Sen_G_0432 | PLD2 | 5338 | CK2α | Inhibition | Unclear | P53-P21 | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 25064843 |
| Sen_G_0433 | TP53 | 7157 | ME1//ME2 | --//-- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 23334421 |
| Sen_G_0434 | WT1 | 7490 | -- | -- | Unclear | KRAS | -- | protein coding | NCI-H522,NCI-H1437,NCI-H1568,NCI-H1650,NCI-H1975,NCI-H2126,NCI-H23,NCI-H358,NCI-H441,NCI-H460,NCI-H727,NCI-H1299,NCI-H2009,NCI-A549 | -- | Aging | Prevent | | HL | 20972333 |
| Sen_G_0435 | WFDC1 | 58189 | -- | -- | Unclear | -- | -- | protein coding | HT-1080,WI-38,IMR-90 | -- | Aging | Prevent | | HL | 18842679 |
| Sen_G_0436 | ATF6 | 22926 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | HL | 27563820 |
| Sen_G_0437 | PLK1 | 5347 | MIR-200C//MIR-141//BMI1//PRC1 | Downregulation//Downregulation//Upregulation//-- | Unclear | -- | -- | protein coding | MDA-MB-468 | -- | Breast cancer | Prevent | | L | 25505268 |
| Sen_G_0438 | NR2E1 | 7101 | CBX7 | Upregulation | Binding to promoter | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 25328137 |
| Sen_G_0439 | SPRY1 | 10252 | -- | -- | Unclear | NF-κB | -- | protein coding | -- | Thyroid gland | Aging | Accelerate | | L | 24270409 |
| Sen_G_0440 | HBP1 | 26959 | DNMT1 | Downregulation | Methylation | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 23249948 |
| Sen_G_0441 | HRAS | 3265 | MYC | -- | Unclear | -- | -- | protein coding | REF | -- | Aging | Accelerate | | L | 19966300 |
| Sen_G_0442 | WNT16B | 51384 | P21//P16 | --//Upregulation | Unclear | PI3K-AKT | Activation | protein coding | MRC-5 | -- | Aging | Accelerate | | HL | 19951988 |
| Sen_G_0443 | MCM | 4171 | -- | -- | Unclear | -- | -- | protein coding | EPC2 | -- | Aging | Accelerate | | L | 19001876 |
| Sen_G_0444 | PFDN5 | 5204 | C-MYC//CD4//ΔNP63α//HERC3 | Downregulation//Downregulation//--//-- | Unclear | -- | -- | protein coding | MCF 10A,H1299 | -- | Aging | Accelerate | | L | 29880857 |
| Sen_G_0445 | TERF1 | 7013 | P53//P21 | --//-- | Unclear | -- | -- | protein coding | Bone marrow cell | Bone marrow,Peripheral blood | Bone marrow failure | Prevent | | L | 22932806 |
| Sen_G_0446 | CLCA2 | 9635 | P53 | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | HL | 22431922 |
| Sen_G_0447 | DNMT3A | 1788 | P21 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | HL | 20473858 |
| Sen_G_0448 | LMNA | 4000 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Hutchinson-Gilford progeria syndrome | Accelerate | | L | 20458013 |
| Sen_G_0449 | ING1 | 3621 | -- | -- | Unclear | P16-RB | Activation | protein coding | Hs68 | -- | Aging | Accelerate | | L | 26439691 |
| Sen_G_0450 | ALOX15B | 247 | P27//RB//RB1CC1 | --// --// -- | Unclear | -- | -- | protein coding | -- | Prostate | Prostate cancer | Accelerate | | L | 24732589 |
| Sen_G_0451 | PRKCI | 5584 | P21 | -- | Unclear | -- | -- | protein coding | MCF-7,T47D | -- | Breast cancer | Prevent | | HL | 22120720 |
| Sen_G_0452 | SIRT1 | 23411 | P53 | Downregulation | Acetylation | -- | -- | protein coding | ADSC | -- | Aging | Prevent | | L | 29803744 |
| Sen_G_0453 | MAP2K3 | 5606 | P53//P38//PRB | Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | 184A1,MCF 10A | -- | Breast cancer | Accelerate | | HL | 21137025 |
| Sen_G_0454 | EGLN1 | 54583 | P21//HTERT//HIF-1α | Upregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | HHUA | -- | Endometrial cancer | Accelerate | | L | 16161047 |
| Sen_G_0455 | THBS1 | 7057 | NOX1//P53//P21 | Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | HPAEC,HAEC | -- | Aging | Accelerate | | L | 29042481 |
| Sen_G_0456 | HIC1 | 3090 | P53//P21/WAF1//SIRT1 | Upregulation//Upregulation//Downregulation | Unclear | -- | -- | protein coding | PANC-1,BxPC-3,AsPC-1 | -- | Pancreatic cancer | Accelerate | | L | 22552606 |
| Sen_G_0457 | IGFBP7 | 3490 | -- | -- | Unclear | -- | -- | protein coding | U87 MG,T98G | Glioma | Aging | Accelerate | | L | 21795858 |
| Sen_G_0458 | CD38 | 952 | CDK4//MITOGEN-ACTIVATEDPROTEINKINASE9//CYCLIN D1 | Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | NPC,5-8F | -- | Nasopharyngeal carcinoma | Prevent | | L | 30535454 |
| Sen_G_0459 | NOTCH1 | 4851 | -- | -- | Unclear | -- | -- | protein coding | HMVEC,HAEC | -- | Atherosclerosis | Accelerate | | HL | 23078884 |
| Sen_G_0460 | FGF21 | 26291 | P53//P21//MFN2//P-DRP1 | --//--//--//-- | Unclear | AMPK | -- | protein coding | MSC | Bone marrow | Aging | Prevent | | L | 31178962 |
| Sen_G_0461 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | -- | Lung | Inflammation | Prevent | | L | 26518879 |
| Sen_G_0462 | GPX7 | 2882 | -- | -- | Unclear | -- | -- | protein coding | OE33,FLO-1 | -- | Oesophageal adenocarcinoma | Accelerate | | L | 23580780 |
| Sen_G_0463 | HIC1 | 3090 | SIRT1 | Downregulation | Binding to promoter | -- | -- | protein coding | TPC-1 | -- | Tumor | Accelerate | | L | 27793057 |
| Sen_G_0464 | HSF1 | 3297 | -- | -- | Unclear | -- | -- | protein coding | MCF 10A | -- | Aging | Prevent | | L | 20622894 |
| Sen_G_0465 | ERBB2 | 2064 | P21 | Upregulation | Unclear | -- | -- | protein coding | MCF 10A | -- | Aging | Accelerate | | L | 20622894 |
| Sen_G_0466 | AKT1 | 207 | P53 | Upregulation | Unclear | -- | -- | protein coding | BJ-T | -- | Aging | Accelerate | | L | 21909130 |
| Sen_G_0467 | SUPT5H | 6829 | HTERT | -- | Unclear | -- | -- | protein coding | RKO,HT29 | -- | Colorectal cancer | Prevent | | L | 26418880 |
| Sen_G_0468 | CTNNB1 | 1499 | CYCLIN D1 | Upregulation | Unclear | P53-P21 | Upregulation | protein coding | Ish-bcat#7,Ishikawa,Ish-tet#8 | -- | Endometrial cancer | Accelerate | | L | 15111320 |
| Sen_G_0469 | RAPGEF4 | 11069 | CALR | -- | Unclear | -- | -- | protein coding | EM1 | -- | Aging | Prevent | | L | 25378661 |
| Sen_G_0470 | CALR | 811 | CALR | -- | Unclear | -- | -- | protein coding | EM1 | -- | Aging | Prevent | | L | 25378661 |
| Sen_G_0471 | MED12 | 9968 | -- | -- | Unclear | -- | -- | protein coding | PC-9,SPCA1 | -- | Lung cancer | Prevent | | HL | 31072327 |
| Sen_G_0472 | GADD45A | 1647 | P53 | -- | Unclear | -- | -- | protein coding | SCL-1 | -- | Skin cancer | Accelerate | | L | 29663367 |
| Sen_G_0473 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | hCMEC/D3 | -- | AIDS | Prevent | | L | 20139322 |
| Sen_G_0474 | SUV39H1 | 6839 | -- | -- | Unclear | -- | -- | protein coding | BEL-7402,SMMC-7721,MHCC97L,HuH-7 | -- | Hepatocellular carcinoma | Prevent | | L | 22991213 |
| Sen_G_0475 | BRCA1 | 672 | -- | -- | Unclear | -- | -- | protein coding | PT-5006 | -- | Breast cancer | Prevent | | L | 30817646 |
| Sen_G_0476 | DUSP | 17362377 | -- | -- | Unclear | TLR4 | Downregulation | protein coding | RPMI8226 | -- | Myeloma | Accelerate | | L | 30280787 |
| Sen_G_0477 | SIRT6 | 51548 | -- | -- | Unclear | HIPPO | Downregulation | protein coding | KM-HM_(31) | -- | Myeloma | Accelerate | | L | 30402853 |
| Sen_G_0478 | LMNA | 4000 | MCP-1//NF-?B | Upregulation//Upregulation | Unclear | -- | -- | protein coding | MSC | Umbilical cord blood | Aging | Accelerate | | L | 29760459 |
| Sen_G_0479 | GATA4 | 2626 | MCP-1//NF-?B | --//-- | Unclear | -- | -- | protein coding | MSC | Umbilical cord blood | Aging | Accelerate | | L | 29760459 |
| Sen_G_0480 | DUSP22 | 56940 | -- | -- | Unclear | MAPK | Activation | protein coding | HS-1 | -- | Skin cancer | Accelerate | | L | 30536326 |
| Sen_G_0481 | HDAC6 | 10013 | P27 | Downregulation | Acetylation | -- | -- | protein coding | PDLSC | Periodontal Ligament | Aging | Prevent | | L | 27562218 |
| Sen_G_0482 | NAMPT | 10135 | P16 | -- | Unclear | -- | -- | protein coding | -- | Aortas | Human Thoracic Aortic Aneurysm Disease | Prevent | | L | 28356339 |
| Sen_G_0483 | VDR | 7421 | P16 | Downregulation | Unclear | -- | -- | protein coding | MSC | Femoral head | Aging | Prevent | | L | 22242193 |
| Sen_G_0484 | LMNA | 4000 | -- | -- | Unclear | -- | -- | protein coding | Primary dermal Fibroblast | Skin | Aging | Accelerate | | L | 18363904 |
| Sen_G_0485 | BMP4 | 652 | PERK//VEGF//BCL2 | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | A549 | -- | Lung cancer | Accelerate | | L | 12959928 |
| Sen_G_0486 | E6 | 1489078 | -- | -- | Unclear | P53-RB | -- | protein coding | SiHa | -- | Cervical cancer | Prevent | | L | 17586029 |
| Sen_G_0487 | E7 | 1489079 | -- | -- | Unclear | P53-RB | -- | protein coding | SiHa | -- | Cervical cancer | Prevent | | L | 17586029 |
| Sen_G_0488 | PEA15 | 8682 | PERK1/2 | -- | Unclear | -- | -- | protein coding | HDF | Foreskin | Aging | Accelerate | | L | 25725291 |
| Sen_G_0489 | FGF2 | 2247 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | Bone marrow | Aging | Prevent | | L | 24491556 |
| Sen_G_0490 | FGF4 | 2249 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | Bone marrow | Aging | Prevent | | L | 24491556 |
| Sen_G_0491 | SETD1A | 9739 | SKP2 | -- | Methylation | -- | -- | protein coding | MDA-MB-231 | -- | Aging | Prevent | | HL | 31253781 |
| Sen_G_0492 | SKP2 | 6502 | P21//P27 | Downregulation//Downregulation | Methylation | -- | -- | protein coding | MDA-MB-231,BT-549 | -- | Aging | Prevent | | HL | 31253781 |
| Sen_G_0493 | CXCR2 | 3579 | -- | -- | Unclear | P53//RB | --//-- | protein coding | MEF,IMR-90 | Embryo | Aging | Accelerate | | L | 18555777 |
| Sen_G_0494 | NSUN2 | 54888 | P27//CDK1//CDC25C | Downregulation//Upregulation//Upregulation | Methylation | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | HL | 26687548 |
| Sen_G_0495 | CXCL1 | 2919 | -- | -- | Unclear | -- | -- | protein coding | NOF,OSCC cell | Mucosa | Oral cancer | Accelerate | | L | 29360827 |
| Sen_G_0496 | IL6 | 3569 | -- | -- | Unclear | -- | -- | protein coding | NOF,OSCC cell | Mucosa | Oral cancer | Accelerate | | L | 29360827 |
| Sen_G_0497 | PIK3CA | 5290 | -- | -- | Unclear | -- | -- | protein coding | EC | Umbilical cord | Vascular malformations | Accelerate | | HL | 29352118 |
| Sen_G_0498 | CCN1 | 3491 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | A549,NCI-H460,NCI-H520 | -- | Lung cancer | Accelerate | | L | 23553737 |
| Sen_G_0499 | DUSP4 | 1846 | -- | -- | Unclear | ERK | Downregulation | protein coding | WI-38 | -- | Aging | Accelerate | | L | 17145763 |
| Sen_G_0500 | RAC1 | 5879 | -- | -- | Unclear | -- | -- | protein coding | HBMEC | -- | Aging | Prevent | | L | 31513781 |
| Sen_G_0501 | FLT1 | 2321 | -- | -- | Unclear | -- | -- | protein coding | HBMEC | -- | Aging | Accelerate | | L | 31513781 |
| Sen_G_0502 | JUN | 3725 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 17126817 |
| Sen_G_0503 | CXCL8 | 3576 | -- | -- | Unclear | AKT-FOXO3A//CXCR2 | --//-- | protein coding | PMSC | -- | Aging | Prevent | | L | 28418782 |
| Sen_G_0504 | PRKDC | 5591 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Idiopathic Pulmonary Fibrosis | Accelerate | | L | 31464599 |
| Sen_G_0505 | TNF | 7124 | P38 | Activation | Unclear | TMTNF-TNFR2 | -- | protein coding | ECFC | -- | Aging | Prevent | | L | 27076598 |
| Sen_G_0506 | EGF | 1950 | -- | -- | Unclear | -- | -- | protein coding | SK-ES-1,RD-ES | -- | Ewing sarcoma | Prevent | | L | 29539615 |
| Sen_G_0507 | SOX1 | 6656 | P21//P27 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | Hep3B | -- | Hepatocellular carcinoma | Accelerate | | HL | 22767186 |
| Sen_G_0508 | SPAG9 | 9043 | P21//CYCLIN B1//CYCLIN D1//CYCLIN E//CDK4//CDK6 | --//--//--//--//--//-- | Unclear | -- | -- | protein coding | MDA-MB-231 | -- | Breast cancer | Prevent | | L | 27449044 |
| Sen_G_0509 | GFPT2 | 9945 | -- | -- | Unclear | -- | -- | protein coding | HBEC3-KT | -- | Aging | Prevent | | HL | 30130254 |
| Sen_G_0510 | UAP1 | 6675 | -- | -- | Unclear | -- | -- | protein coding | HBEC3-KT | -- | Aging | Prevent | | HL | 30130254 |
| Sen_G_0511 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HCA2 | -- | Aging | Accelerate | | L | 24910096 |
| Sen_G_0512 | RB1 | 5925 | -- | -- | Unclear | -- | -- | protein coding | HCA2 | -- | Aging | Accelerate | | L | 24910096 |
| Sen_G_0513 | TXNRD1 | 7296 | CAVEOLIN-1 | Downregulation | Unclear | -- | -- | protein coding | NIH-3T3 | -- | Aging | Prevent | | L | 19820694 |
| Sen_G_0514 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 19648966 |
| Sen_G_0515 | CDKN1A | 1026 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 19648966 |
| Sen_G_0516 | CCN1 | 3491 | -- | -- | Unclear | -- | -- | protein coding | HSC | Liver | Liver disease | Accelerate | | HL | 29105104 |
| Sen_G_0517 | EIF4EBP1 | 1978 | P53 | Downregulation | Unclear | -- | -- | protein coding | A549,AD32 | -- | Aging | Prevent | | L | 21173253 |
| Sen_G_0518 | TP73 | 7161 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | HL | 29511339 |
| Sen_G_0519 | ERBB2 | 2064 | P21//SURVIVIN | Upregulation//Downregulation | Unclear | -- | -- | protein coding | MCF 10A | -- | Cancer | Accelerate | | L | 20622894 |
| Sen_G_0520 | HSF1 | 3297 | -- | -- | Unclear | -- | -- | protein coding | MCF 10A | -- | Cancer | Prevent | | L | 20622894 |
| Sen_G_0521 | PTEN | 5728 | -- | -- | Unclear | PI3K-AKT | Activation | protein coding | BJ-T | -- | Aging | Prevent | | L | 21909130 |
| Sen_G_0522 | PIK3CA | 5290 | -- | -- | Unclear | PI3K-AKT | Activation | protein coding | BJ-T | -- | Aging | Accelerate | | L | 21909130 |
| Sen_G_0523 | AKT1 | 207 | -- | -- | Unclear | P53//MTORC1 | Upregulation//-- | protein coding | BJ-T | -- | Aging | Accelerate | | L | 21909130 |
| Sen_G_0524 | HRAS | 3265 | -- | -- | Unclear | -- | -- | protein coding | BJ-T | -- | Aging | Accelerate | | L | 21909130 |
| Sen_G_0525 | PIK3CA | 5290 | -- | -- | Unclear | -- | -- | protein coding | EC | -- | Vascular malformations | Accelerate | | L | 29352118 |
| Sen_G_0526 | CDK4 | 1019 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 27206849 |
| Sen_G_0527 | CDK6 | 1021 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 27206849 |
| Sen_G_0528 | SIRT6 | 51548 | H3K9 | -- | Unclear | NF-κB | Downregulation | protein coding | Primary human keratinocyte | -- | Aging | Prevent | | HL | 19135889 |
| Sen_G_0529 | PNPT1 | 87178 | -- | -- | Unclear | NF-κB | Activation | protein coding | HeLa | -- | Aging | Accelerate | | HL | 15492272 |
| Sen_G_0530 | BLVRA | 644 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | L | 21099244 |
| Sen_G_0531 | WRN | 7486 | P16 | -- | Unclear | P53//RB | --//-- | protein coding | WI-38 | -- | Werner syndrome | Prevent | | HL | 16287861 |
| Sen_G_0532 | BLM | 641 | P16 | -- | Unclear | P53//RB | --//-- | protein coding | WI-38 | -- | Werner syndrome | Prevent | | HL | 16287861 |
| Sen_G_0533 | GCG | 2641 | DPP-4//CREB | Upregulation//Activation | Unclear | CAMP-PKA | -- | protein coding | HUVEC | -- | Diabetes | Prevent | | L | 20448207 |
| Sen_G_0534 | SRC | 6714 | -- | -- | Unclear | -- | -- | protein coding | Human endothelial cell | -- | Aging | Accelerate | | L | 14963003 |
| Sen_G_0535 | SIRT1 | 23411 | -- | -- | Unclear | LKB1-AMPK//AKT | Activation//Activation | protein coding | PAEC | -- | Aging | Prevent | | L | 20203304 |
| Sen_G_0536 | BMI1 | 648 | -- | -- | Unclear | -- | -- | protein coding | Renal cell | Kidney | Renal tubulointerstitial injury | Prevent | | HL | 28790310 |
| Sen_G_0537 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | Renal cell | Kidney | Renal tubulointerstitial injury | Accelerate | | HL | 28790310 |
| Sen_G_0538 | PLA2R1 | 22925 | -- | -- | Unclear | P53-FDPS | -- | protein coding | MRC-5 | -- | Hutchinson–Gilford progeria syndrome | Accelerate | | L | 30216637 |
| Sen_G_0539 | CXCR4 | 7852 | AKT//CREB//P53 | Activation//Activation//Activation | Phosphorylation | CXCL12-CXCR4 | Activation | protein coding | SH-SY5Y | -- | Alzheimer's disease | Prevent | | L | 30080220 |
| Sen_G_0540 | TP53 | 7157 | P21 | Upregulation | Unclear | -- | -- | protein coding | HSC | Spine,tibias,Skin | Aging | Accelerate | | L | 29557783 |
| Sen_G_0541 | COL17A1 | 1308 | ELANE | -- | Unclear | -- | -- | protein coding | HFSC | Hair | Aging | Prevent | | HL | 26912707 |
| Sen_G_0542 | CDKN2A | 1029 | CYCLIN D1 | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | | L | 27743340 |
| Sen_G_0543 | SIRT6 | 51548 | H3K18AC | -- | Unclear | -- | -- | protein coding | U2OS | -- | Aging | Prevent | | HL | 27043296 |
| Sen_G_0544 | ITGB3 | 3690 | CBX7 | -- | Unclear | P53-P21//TGF-β | Activation//Activation | protein coding | BF | -- | Aging | Accelerate | | L | 28273461 |
| Sen_G_0545 | DLX3 | 1747 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | -- | Aging | Accelerate | | HL | 27924851 |
| Sen_G_0546 | CIZ1 | 25792 | -- | -- | Unclear | NF-κB | -- | protein coding | MEF | Brain | Neurodegenerative disease | Prevent | | L | 29154038 |
| Sen_G_0547 | JAG1 | 182 | P16//CCND1 | Downregulation//Upregulation | Unclear | JAG1-NOTCH-HES1 | Activation | protein coding | MSC | -- | Aging | Prevent | | L | 28151468 |
| Sen_G_0548 | CD9 | 928 | -- | -- | Unclear | SIRT1 | -- | protein coding | A549 | Bone,Muscle,Adipose,Hair,Lung | Chronic obstructive pulmonary disease | Prevent | | HL | 29572511 |
| Sen_G_0549 | CD81 | 975 | -- | -- | Unclear | SIRT1 | -- | protein coding | A549 | Bone,Muscle,Adipose,Hair,Lung | Chronic obstructive pulmonary disease | Prevent | | HL | 29572511 |
| Sen_G_0550 | FLT1 | 2321 | -- | -- | Unclear | P21-P53 | Activation | protein coding | HUVEC | -- | Alzheimer's disease | Accelerate | | L | 30576228 |
| Sen_G_0551 | LMNA | 4000 | UCP1//BETA3-AR//PRDM16 | --// --// -- | Unclear | -- | -- | protein coding | -- | Mice | Aging | Prevent | | L | 30116163 |
| Sen_G_0552 | DLX2 | 1746 | -- | -- | Unclear | P53-P21//ATM-P53 | Downregulation//Downregulation | protein coding | BJ | -- | Aging | Accelerate | | HL | 26833729 |
| Sen_G_0553 | SIRT1 | 23411 | P53//CREB | --//Inhibition | Unclear | PI3K-AKT | -- | protein coding | SH-SY5Y | -- | Alzheimer's disease | Prevent | | L | 28962864 |
| Sen_G_0554 | SIRT1 | 23411 | P21 | Downregulation | Unclear | -- | -- | protein coding | VSMC | -- | Abdominal aortic aneurysms | Prevent | | HL | 27650558 |
| Sen_G_0555 | CAV1 | 857 | IFT88//AURKA | --//-- | Unclear | -- | -- | protein coding | WI-38,IMR-90 | -- | Aging | Prevent | | L | 30596512 |
| Sen_G_0556 | NBR1 | 4077 | P53//P21//P38 | --//--//Downregulation | Unclear | ERSTRESS-ATF6A | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 30260700 |
| Sen_G_0557 | SIRT1 | 23411 | -- | -- | Unclear | RUNX2 | Downregulation | protein coding | VSMC | -- | Diabetes | Prevent | | L | 30696833 |
| Sen_G_0558 | SCN9A | 6335 | NF-KB | -- | Unclear | CA-RB-E2F | -- | protein coding | HEC | -- | Aging | Accelerate | | HL | 29446526 |
| Sen_G_0559 | CST1 | 1469 | CATB | -- | Unclear | GSK3β | -- | protein coding | MDA-MB-231,SW480 | -- | Aging | Prevent | | L | 28383558 |
| Sen_G_0560 | ATF6 | 22926 | -- | -- | Unclear | COX-2-PGE2 | Activation | protein coding | NHDF | -- | Aging | Accelerate | | L | 28803844 |
| Sen_G_0561 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | VSMC | Plaques and normal vessel | Atherosclerosis | Prevent | | L | 23224247 |
| Sen_G_0562 | CEBPG | 1054 | C/EBPβ | Inhibition | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | | HL | 23775115 |
| Sen_G_0563 | SIRT1 | 23411 | C-MYC//HTERT | --//-- | Unclear | -- | -- | protein coding | HUC-F2 | -- | Aging | Prevent | | L | 22197555 |
| Sen_G_0564 | FOXQ1 | 94234 | SIRT1//IL-6//IL-8//P16 | Upregulation//Downregulation//Downregulation//Downregulation | Binding to promoter | NF-κB | Upregulation | protein coding | 2BS | -- | Esophageal cancer | Prevent | | L | 28726780 |
| Sen_G_0565 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Diabetic vascular complication | Prevent | | L | 26629991 |
| Sen_G_0566 | PRKAA1 | 5562 | SIRT1 | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Diabetic vascular complication | Prevent | | L | 26629991 |
| Sen_G_0567 | NRAS | 4893 | -- | -- | Unclear | MAPK//AKT//P16INK4A-PRB//P53-P21WAF1 | Activation//Activation//Activation//Activation | protein coding | Melanocyte | -- | Aging | Accelerate | | L | 20157537 |
| Sen_G_0568 | TGFB1 | 7040 | MAD1//MYC | Upregulation//Downregulation | Acetylation | -- | -- | protein coding | U937 | -- | Cancer | Accelerate | | L | 19766114 |
| Sen_G_0569 | BAZ1A | 11177 | SMARCA5 | -- | Unclear | SMAD3-P21 | -- | protein coding | A549,U2OS | -- | Cancer | Prevent | | HL | 31085244 |
| Sen_G_0570 | RRM2B | 50484 | -- | -- | Unclear | P38 MAPK//P53 | --//-- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 23139867 |
| Sen_G_0571 | NR2E1 | 7101 | P21//SIRT1 | Downregulation//Upregulation | Unclear | -- | -- | protein coding | LNCaP,DU 145 | -- | Prostate cancer | Prevent | | L | 25557355 |
| Sen_G_0572 | ALPL | 249 | ATP | -- | Unclear | AMPKα | -- | protein coding | MSC | Adipose | Aging | Prevent | | HL | 30210899 |
| Sen_G_0573 | CAV1 | 857 | SIRT1 | -- | Unclear | P53-P21 | -- | protein coding | A549 | -- | Aging | Prevent | | L | 28514055 |
| Sen_G_0574 | TBX3 | 6926 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Ulnar-mammary syndrome | Prevent | | HL | 15289316 |
| Sen_G_0575 | TBX3 | 6926 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Ulnar-mammary syndrome | Accelerate | | HL | 15289316 |
| Sen_G_0576 | TAT | 6898 | -- | -- | Unclear | NF-κB | Activation | protein coding | MSC | -- | AIDS | Accelerate | | L | 25847297 |
| Sen_G_0577 | NEF | 156110 | BECLIN1 | Downregulation | Unclear | -- | -- | protein coding | MSC | -- | AIDS | Accelerate | | L | 25847297 |
| Sen_G_0578 | GDF15 | 9518 | ERK | Activation | Unclear | P16-RB | Upregulation | protein coding | Aortic endothelial cell | -- | Atherosclerosis | Accelerate | | HL | 26909594 |
| Sen_G_0579 | PAK4 | 10298 | RELB | Downregulation | Phosphorylation | NF-κB | Downregulation | protein coding | Hs 578T | -- | Breast cancer | Prevent | | HL | 31399573 |
| Sen_G_0580 | CCND1 | 595 | -- | -- | Unclear | P38-FOXO3A-P27 | -- | protein coding | MCF-7 | -- | Breast cancer | Prevent | | L | 29880532 |
| Sen_G_0581 | FBXO46 | 23403 | FBXO31 | Downregulation | Phosphorylation | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 30171069 |
| Sen_G_0582 | POT1 | 25913 | -- | -- | Unclear | P53//P16 | --//-- | protein coding | MRC-5,WI-38,NHF | -- | Aging | Prevent | | L | 18089797 |
| Sen_G_0583 | POT1 | 25913 | -- | -- | Unclear | P53 | -- | protein coding | MRC-5,WI-38,NHF | -- | Aging | Prevent | | L | 18089797 |
| Sen_G_0584 | MYC | 4609 | CDKN1A//MYOT//MTOR//UBE2E1 | --//--//--//-- | Unclear | TGFβ | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 29138277 |
| Sen_G_0585 | BRD4 | 23476 | -- | -- | Unclear | E2F-MIR-106B-P21 | -- | protein coding | MKN28 | -- | Gastric cancer | Prevent | | L | 29434197 |
| Sen_G_0586 | EZH2 | 2146 | P21//P16 | --//-- | Unclear | -- | -- | protein coding | SGC-7901 | -- | Gastric cancer | Prevent | | L | 24588771 |
| Sen_G_0587 | TNF | 7124 | P21 | Upregulation | Unclear | -- | -- | protein coding | ISO-HAS | -- | Aging | Accelerate | | L | 26802937 |
| Sen_G_0588 | PTEN | 5728 | -- | -- | Unclear | PI3K-MTOR | -- | protein coding | MEF | -- | Prostate cancer | Prevent | | L | 20197621 |
| Sen_G_0589 | E2F7 | 144455 | -- | -- | Unclear | P53 | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 22802529 |
| Sen_G_0590 | TGFB2 | 7042 | -- | -- | Unclear | P16-RB | Activation | protein coding | TM | Eye | Primary open-angle glaucoma | Accelerate | | L | 20554622 |
| Sen_G_0591 | LMNA | 4000 | P16//P21 | --//-- | Unclear | -- | -- | protein coding | Fibroblast | -- | Lipodystrophic syndromes | Accelerate | | L | 17612587 |
| Sen_G_0592 | NPM1 | 4869 | P53 | -- | Unclear | -- | -- | protein coding | MIP101,RKO,HCT116 | -- | Colorectal cancer | Prevent | | L | 23536448 |
| Sen_G_0593 | ATRX | 546 | HRAS | -- | Unclear | -- | -- | protein coding | WD/DDLS | -- | Aging | Accelerate | | HL | 28855512 |
| Sen_G_0594 | SIAH1 | 6477 | P53//TRF2 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | MRC-5 | -- | Aging | Accelerate | | L | 21057505 |
| Sen_G_0595 | MYC | 4609 | P14//P53//USP10 | --//--//Upregulation | Unclear | -- | -- | protein coding | HFF | -- | Aging | Accelerate | | HL | 29472714 |
| Sen_G_0596 | USP10 | 9100 | P14 | -- | Unclear | -- | -- | protein coding | IMR-90,HFF | -- | Aging | Accelerate | | HL | 29472714 |
| Sen_G_0597 | SUSD2 | 56241 | TGFβ//SMAD2/3//LGALS1 | Downregulation//--//-- | Unclear | -- | -- | protein coding | Ishikawa | -- | Endometrial cancer | Prevent | | L | 28841682 |
| Sen_G_0598 | SPI1 | 6688 | -- | -- | Unclear | P38 MAPK | Activation | protein coding | BJ,WI-38 | -- | Acute leukemia | Accelerate | | L | 28912174 |
| Sen_G_0599 | IL4 | 3565 | STAT6//P38MAPK | Activation//Activation | Unclear | -- | -- | protein coding | CAKI-1,A498,786-O | -- | Aging | Accelerate | | HL | 23935100 |
| Sen_G_0600 | MAD2L1 | 4085 | P14 | -- | Unclear | P53-P21 | -- | protein coding | IMR-90,MCF 10A | -- | Aging | Prevent | | L | 22170163 |
| Sen_G_0601 | SLC16A7 | 9194 | -- | -- | Unclear | -- | -- | protein coding | LoVo,HT29,HCT-8,HCT116,SW480 ,MKN45,MKN74 | -- | Colorectal cancer | Prevent | | L | 22964484 |
| Sen_G_0602 | FIS1 | 51024 | OPA1 | -- | Unclear | -- | -- | protein coding | Chang | -- | Aging | Prevent | | L | 17545159 |
| Sen_G_0603 | NFKB2 | 4791 | EZH2//NIK | Upregulation//-- | Unclear | -- | -- | protein coding | A375 | -- | Melanoma | Prevent | | L | 26364600 |
| Sen_G_0604 | CAV1 | 857 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 12134086 |
| Sen_G_0605 | MIF | 4282 | -- | -- | Unclear | PI3K-AKT | Activation | protein coding | MSC | -- | Aging | Prevent | | L | 29207187 |
| Sen_G_0606 | SIRT6 | 51548 | -- | -- | Unclear | -- | -- | protein coding | HuH-7,Hep3B | -- | Hepatocellular carcinoma | Prevent | | HL | 27824900 |
| Sen_G_0607 | CDK1 | 983 | P21 | Upregulation | Unclear | -- | -- | protein coding | RPE,U2OS | -- | Aging | Accelerate | | L | 28345297 |
| Sen_G_0608 | CDK2 | 1017 | P21 | Upregulation | Unclear | -- | -- | protein coding | RPE,U2OS | -- | Aging | Accelerate | | L | 28345297 |
| Sen_G_0609 | PRMT1 | 3276 | ZEB1 | Activation | Methylation | -- | -- | protein coding | MCF-7,MDA-MB-231 | -- | Breast cancer | Prevent | | L | 26813495 |
| Sen_G_0610 | KDR | 3791 | P21 | -- | Unclear | PI3K-AKT | -- | protein coding | -- | Colon | Colitis associated cancer | Prevent | | L | 25797700 |
| Sen_G_0611 | MYC | 4609 | P15INK4B//P21CIP | --//-- | Unclear | -- | -- | protein coding | -- | Liver,Lymphoma | Cancer | Prevent | | L | 17664422 |
| Sen_G_0612 | BRCA1 | 672 | P16 | -- | Unclear | -- | -- | protein coding | MEC | -- | Breast cancer | Prevent | | L | 27811360 |
| Sen_G_0613 | IGF1 | 3479 | GPX1 | Upregulation | Unclear | PI3K | -- | protein coding | Aortic endothelial cell | -- | Atherosclerosis | Prevent | | L | 23261989 |
| Sen_G_0614 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | GBM | -- | Ataxia telangiectasia | Prevent | | L | 14570874 |
| Sen_G_0615 | SOX5 | 6660 | -- | -- | Unclear | -- | -- | protein coding | GBM | Brain | Glioblastoma | Accelerate | | HL | 28687615 |
| Sen_G_0616 | SOX6 | 55553 | -- | -- | Unclear | -- | -- | protein coding | GBM | Brain | Glioblastoma | Accelerate | | HL | 28687615 |
| Sen_G_0617 | SOX21 | 11166 | P53 | Upregulation | Unclear | -- | -- | protein coding | GBM | Brain | Glioblastoma | Accelerate | | HL | 28687615 |
| Sen_G_0618 | TP53 | 7157 | OCT4A//P21 | --//-- | Unclear | -- | -- | protein coding | PA-1(ATCC) | -- | Aging | Prevent | | L | 23287532 |
| Sen_G_0619 | AGT | 183 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | VSMC | Aorta | Atherosclerosis | Accelerate | | L | 16908765 |
| Sen_G_0620 | BAG3 | 9531 | P27 | -- | Unclear | STAT3-SKP2-P27 | -- | protein coding | A172 | -- | Glioblastoma | Prevent | | L | 25412315 |
| Sen_G_0621 | CDKN2A | 1029 | BMI1 | -- | Unclear | -- | -- | protein coding | HCEC | -- | Aging | Accelerate | | L | 27739458 |
| Sen_G_0622 | CTNND1 | 1500 | P16//BMI1 | --//-- | Unclear | JAK2-STAT3//RHOA-ROCK | --//-- | protein coding | HCEC | -- | Aging | Prevent | | L | 27739458 |
| Sen_G_0623 | ZBTB33 | 10009 | P16//BMI1 | --//-- | Unclear | JAK2-STAT3//RHOA-ROCK | --//-- | protein coding | HCEC | -- | Aging | Prevent | | L | 27739458 |
| Sen_G_0624 | PRMT6 | 55170 | P21 | Downregulation | Unclear | -- | -- | protein coding | MCF-7,MDA-MB-231 | -- | Breast cancer | Prevent | | HL | 22987071 |
| Sen_G_0625 | MYBL2 | 4605 | -- | -- | Unclear | ROS-P53-P21 | -- | protein coding | HAEC | -- | Aging | Prevent | | L | 27878894 |
| Sen_G_0626 | KLF6 | 1316 | -- | -- | Unclear | -- | -- | protein coding | NIH-3T3 | -- | Aging | Accelerate | | L | 31824948 |
| Sen_G_0627 | SENP1 | 29843 | -- | -- | Unclear | P53 | -- | protein coding | HFF | Skin | Aging | Prevent | | L | 18616636 |
| Sen_G_0628 | CDK2 | 1017 | P53//RB | --//-- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Prevent | | L | 25149358 |
| Sen_G_0629 | HMGA1 | 3159 | P16 | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 16901784 |
| Sen_G_0630 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | mTert?/?Fibroblast | -- | Aging | Prevent | | HL | 31481614 |
| Sen_G_0631 | PROM1 | 8842 | -- | -- | Unclear | WNT-β-CATENIN | Activation | protein coding | CD1331 RPC | -- | Acute kidney injury | Prevent | | HL | 29431914 |
| Sen_G_0632 | STAG2 | 10735 | -- | -- | Unclear | -- | -- | protein coding | BJ-2 | -- | Cancer | Accelerate | | L | 28819029 |
| Sen_G_0633 | CHEK1 | 1111 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Foreskin | Aging | Accelerate | | L | 21995812 |
| Sen_G_0634 | FANCD2 | 2177 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Foreskin | Aging | Accelerate | | L | 21995812 |
| Sen_G_0635 | FBXO5 | 26271 | APC/C//E2F//CYCLIN E1//ATM | --//--//--//-- | Unclear | -- | -- | protein coding | RPE | -- | Aging | Prevent | | HL | 17875940 |
| Sen_G_0636 | RB1 | 5925 | DNMT | Upregulation | Unclear | -- | -- | protein coding | MSC | -- | Aging | Prevent | | L | 25455074 |
| Sen_G_0637 | CIP2A | 57650 | -- | -- | Unclear | -- | -- | protein coding | AGS | -- | Gastric cancer | Prevent | | L | 18559589 |
| Sen_G_0638 | IL1B | 3553 | CASPASE-1//NLRP3 | --//-- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 28064010 |
| Sen_G_0639 | SATB1 | 6304 | P16 | Upregulation | Unclear | RB-E2F1 | -- | protein coding | MEF | -- | Breast cancer | Accelerate | | L | 23686316 |
| Sen_G_0640 | PAK4 | 10298 | P16//P19ARF//RAF | Upregulation//Upregulation//Activation | Unclear | ERK-MAPK | Activation | protein coding | MEF | -- | Aging | Accelerate | | L | 16227603 |
| Sen_G_0641 | CDC73 | 79577 | -- | -- | Unclear | P53-P21 | -- | protein coding | 293T,A549,HUVEC | -- | Cancer | Prevent | | HL | 29621547 |
| Sen_G_0642 | PRODH | 5625 | -- | -- | Unclear | -- | -- | protein coding | U2OS | -- | Aging | Accelerate | | L | 28264926 |
| Sen_G_0643 | TAX | 1491938 | RELA//HBZ | --//-- | Unclear | NF-κB | Activation | protein coding | HeLa | -- | Aging | Accelerate | | L | 21552325 |
| Sen_G_0644 | SKP2 | 6502 | P27//P21//ATF4 | --//--//-- | Unclear | -- | -- | protein coding | MEF | -- | Prostate cancer | Prevent | | L | 20237562 |
| Sen_G_0645 | KCNJ12 | 3768 | P27 | -- | Unclear | -- | -- | protein coding | PC-3,DU 145,LNCaP,MKN74,SNU638,SNU668,MCF-7,SK-BR-3,T47D | -- | Cancer | Prevent | | L | 20841375 |
| Sen_G_0646 | HRAS | 3265 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 19421407 |
| Sen_G_0647 | CDKN2A | 1029 | -- | -- | Unclear | P16-CDK4-PRB | -- | protein coding | 2BS | -- | Aging | Accelerate | | L | 11606567 |
| Sen_G_0648 | SOX10 | 6663 | E2F1//RB//MITF//P16//P27//P21 | --//--//--//--//--//-- | Unclear | -- | -- | protein coding | 0002-ARM,UACC 1022,0380-MMU | -- | Melanoma | Prevent | | HL | 23913827 |
| Sen_G_0649 | E2 | 1489080 | E7 | -- | Unclear | RB | Activation | protein coding | HeLa | -- | Aging | Accelerate | | L | 15126344 |
| Sen_G_0650 | SOX5 | 6660 | P27//AKT | Upregulation//Downregulation | Unclear | PDGFB | -- | protein coding | Glial cell | -- | Glioma | Accelerate | | HL | 19219070 |
| Sen_G_0651 | G6PD | 2539 | -- | -- | Unclear | -- | -- | protein coding | HFF | -- | Aging | Prevent | | L | 10980404 |
| Sen_G_0652 | WIF1 | 11197 | -- | -- | Unclear | WNT | Downregulation | protein coding | LN-229,LN319 | -- | Glioblastoma | Accelerate | | HL | 21642372 |
| Sen_G_0653 | CXCL8 | 3576 | HTERT | Upregulation | Unclear | NF-κB//P38 MAPK | Downregulation//Downregulation | protein coding | HUVEC | -- | Aging | Prevent | | L | 23597430 |
| Sen_G_0654 | NAT10 | 55226 | -- | -- | Unclear | TNPO1 | -- | protein coding | HGPS | -- | Hutchinson-Gilford progeria syndrome | Accelerate | | HL | 29970603 |
| Sen_G_0655 | NUTF2 | 10204 | -- | -- | Unclear | -- | -- | protein coding | HGPS(HGPS 11513),Fibroblast | -- | Hutchinson-Gilford progeria syndrome | Prevent | | HL | 29970603 |
| Sen_G_0656 | OPA1 | 4976 | -- | -- | Unclear | -- | -- | protein coding | -- | Liver,Skin,Colon | Aging | Prevent | | L | 28552492 |
| Sen_G_0657 | E2 | 1489080 | -- | -- | Unclear | P53 | Upregulation | protein coding | HeLa/LXSN-1 | -- | Cervical cancer | Accelerate | | L | 15047823 |
| Sen_G_0658 | SATB1 | 6304 | P21 | Downregulation | Unclear | -- | -- | protein coding | -- | Brain | Parkinson's disease | Prevent | | HL | 31543366 |
| Sen_G_0659 | SHH | 6469 | SERPINB2 | Downregulation | Unclear | -- | -- | protein coding | Human endometrial stem cell | -- | Recurrent pregnancy loss | Prevent | | HL | 31080015 |
| Sen_G_0660 | SPRY1 | 10252 | P53//P21//RB | --//--//-- | Unclear | RAS-MAPK//NF-κB | --//-- | protein coding | ASC | -- | Aging | Prevent | | HL | 32304210 |
| Sen_G_0661 | SRSF3 | 6428 | PTEN | -- | Unclear | PI3K-AKT | -- | protein coding | 293T,HUVEC,MEF,NIH-3T3 | -- | Aging | Prevent | | HL | 30835716 |
| Sen_G_0662 | ITGB4 | 3691 | -- | -- | Unclear | P53-P21 | -- | protein coding | Mice airway epithelial cell | Mice airway epithelia | Asthma | Prevent | | L | 30636108 |
| Sen_G_0663 | TRPC7 | 57113 | -- | -- | Unclear | -- | -- | protein coding | -- | Skin | Aging | Accelerate | | HL | 31755176 |
| Sen_G_0664 | TET1 | 80312 | P53 | -- | Binding to promoter | -- | -- | protein coding | H1299,H1975,H226,H441,Calu-6 | -- | Lung cancer | Prevent | | HL | 30622117 |
| Sen_G_0665 | SARS1 | 6301 | POT1 | -- | Unclear | -- | -- | protein coding | HeLa 1.2.11,BJ | -- | Aging | Accelerate | | L | 31815007 |
| Sen_G_0666 | TLR4 | 7099 | P16//HDAC2 | Downregulation//-- | Acetylation | -- | -- | protein coding | MLEC | -- | Emphysema and COPD | Prevent | | L | 30790400 |
| Sen_G_0667 | MANF | 7873 | -- | -- | Unclear | -- | -- | protein coding | -- | Adipose | Aging | Prevent | | HL | 31489403 |
| Sen_G_0668 | CD9 | 928 | -- | -- | Unclear | PI3K-AKT-MTOR-P53 | Activation | protein coding | HUVEC | -- | Atherosclerosis | Accelerate | | HL | 32346137 |
| Sen_G_0669 | PRDX6 | 9588 | SIRT1 | -- | Unclear | P53-P21 | -- | protein coding | C2C12 | Gastrocnemius | Metabolic Sarcopenia | Prevent | | HL | 32316601 |
| Sen_G_0670 | BMI1 | 648 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | -- | Aging | Prevent | | HL | 31257132 |
| Sen_G_0671 | SIRT2 | 22933 | IL-1β//SOD1//SOD2 | Downregulation//Upregulation//Upregulation | Unclear | P53-P21 | Downregulation | protein coding | NP | -- | Disc degenerative disease | Prevent | | L | 30981502 |
| Sen_G_0672 | LSG1 | 55341 | -- | -- | Unclear | P53 | -- | protein coding | MRC-5 | -- | Aging | Prevent | | HL | 31148378 |
| Sen_G_0673 | SBDS | 51119 | -- | -- | Unclear | P53 | -- | protein coding | MRC-5 | -- | Aging | Prevent | | HL | 31148378 |
| Sen_G_0674 | LMNB1 | 4001 | -- | -- | Unclear | MTOR | Downregulation | protein coding | HBEC | -- | Chronic obstructive pulmonary disease | Prevent | | L | 30692212 |
| Sen_G_0675 | STUB1 | 10273 | BMAL1 | Downregulation | Ubiquitylation | -- | -- | protein coding | HEK293T | -- | Aging | Prevent | | L | 32041778 |
| Sen_G_0676 | BTK | 695 | -- | -- | Unclear | -- | -- | protein coding | -- | Brain | Aging | Accelerate | | L | 31736210 |
| Sen_G_0677 | CDKN2A | 1029 | CYCLIN D | -- | Unclear | IGF-1-AKT1 | -- | protein coding | AECII | -- | Chronic obstructive pulmonary disease | Accelerate | | HL | 31428695 |
| Sen_G_0678 | ATP6AP2 | 10159 | -- | -- | Unclear | WNT-YAP | Activation | protein coding | C2C12 | -- | Sarcopenia | Accelerate | | L | 31282603 |
| Sen_G_0679 | SIRT1 | 23411 | CAT//SOD | --//-- | Unclear | -- | -- | protein coding | HUVEC | -- | Heart failure | Prevent | | L | 28331525 |
| Sen_G_0680 | GDF11 | 10220 | -- | -- | Unclear | SMAD2/3 | -- | protein coding | HFL-1,Primary bronchial epithelial cell | -- | Chronic obstructive pulmonary disease | Prevent | | L | 28455454 |
| Sen_G_0681 | SATB2 | 23314 | -- | -- | Unclear | -- | -- | protein coding | B-MSC | Bone | Aging | Prevent | | HL | 25200657 |
| Sen_G_0682 | NAMPT | 10135 | SIRT1//P53 | Activation//Downregulation | Unclear | -- | -- | protein coding | SMC | -- | Atherosclerosis | Prevent | | L | 17307730 |
| Sen_G_0683 | SATB2 | 23314 | -- | -- | Unclear | NANOG | Upregulation | protein coding | B-MSC | -- | Aging | Prevent | | L | 27632702 |
| Sen_G_0684 | PRDX2 | 7001 | -- | -- | Unclear | P16 | Downregulation | protein coding | Human primary Chondrocyte | -- | Osteoarthritis | Prevent | | L | 32329817 |
| Sen_G_0685 | MSN | 4478 | -- | -- | Unclear | -- | -- | protein coding | HDMEC | -- | Aging | Prevent | | L | 20376899 |
| Sen_G_0686 | SGK1 | 6446 | HTERT | -- | Unclear | -- | -- | protein coding | HUVEC,SGK1WT | -- | Atherosclerosis | Prevent | | L | 26230157 |
| Sen_G_0687 | SEMA4C | 54910 | -- | -- | Unclear | P53-P21 | -- | protein coding | MDA-MB-231 | -- | Breast cancer | Prevent | | HL | 31308149 |
| Sen_G_0688 | ACKR3 | 57007 | ANDROGEN RECEPTOR(AR) | Downregulation | Binding to promoter | EGFR | -- | protein coding | C4-2B | -- | Prostate cancer | Prevent | | HL | 28596572 |
| Sen_G_0689 | TRMT9B | 57604 | LIN9//HIF1-A | Upregulation//Upregulation | Unclear | -- | -- | protein coding | Htrm9L | Tumour sample | Colorectal cancer | Accelerate | | HL | 23381944 |
| Sen_G_0690 | MYC | 4609 | -- | -- | Unclear | -- | -- | protein coding | HT-1080 | -- | Cancer | Accelerate | | L | 29462755 |
| Sen_G_0691 | FBXO31 | 79791 | MDM2//P53//ATM | Downregulation//Upregulation//-- | Phosphorylation | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | | L | 26124108 |
| Sen_G_0692 | SQSTM1 | 8878 | -- | -- | Unclear | -- | -- | protein coding | PaSC | -- | Pancreatic ductal adenocarcinoma | Prevent | | HL | 31182922 |
| Sen_G_0693 | SAMHD1 | 25939 | -- | -- | Unclear | -- | -- | protein coding | HeLa | -- | Aicardi–Goutières syndrome | Prevent | | HL | 24445253 |
| Sen_G_0694 | TOP1 | 7150 | AURORA-A | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | L | 20682043 |
| Sen_G_0695 | TERT | 7015 | -- | -- | Unclear | NF-κB | -- | protein coding | U937 | -- | Atherosclerosis | Prevent | | L | 21106948 |
| Sen_G_0696 | SLC4A2 | 6522 | -- | -- | Unclear | -- | -- | protein coding | BEC | -- | Primary biliary cholangitis | Prevent | | L | 27592379 |
| Sen_G_0697 | FANCD2 | 2177 | TAP63//USP1 | Upregulation//-- | Unclear | -- | -- | protein coding | Fancd2+/+ epithelial cell | Skin | Fanconi anemia | Accelerate | | HL | 23806336 |
| Sen_G_0698 | PIP4K2A | 5305 | -- | -- | Unclear | PI3K-AKT | -- | protein coding | BT-474 | -- | Breast cancer | Prevent | | HL | 24209622 |
| Sen_G_0699 | PIP4K2B | 8396 | -- | -- | Unclear | PI3K-AKT | -- | protein coding | BT-474 | -- | Breast cancer | Prevent | | HL | 24209622 |
| Sen_G_0700 | GNMT | 27232 | DEPTOR | -- | Unclear | MTOR-RAPTOR | Activation | protein coding | HuH-7-GNMT,HuH-7-GFP,HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 22160218 |
| Sen_G_0701 | SIRT1 | 23411 | BMI1 | Activation | Unclear | -- | -- | protein coding | BM-MSC | -- | Osteoporosis | Prevent | | HL | 30690778 |
| Sen_G_0702 | NAMPT | 10135 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 30778219 |
| Sen_G_0703 | KDM4A | 9682 | CHD5 | Inhibition | Unclear | P53 | Downregulation | protein coding | IMR-90 | -- | Aging | Prevent | | L | 23168260 |
| Sen_G_0703 | KDM4A | 9682 | CHD5 | Inhibition | Unclear | P53 | Downregulation | protein coding | IMR-90 | -- | Aging | Prevent | | L | 23168260 |
| Sen_G_0704 | ABCC3 | 8714 | -- | -- | Unclear | -- | -- | protein coding | HEC-TR | -- | Aging | Accelerate | | L | 26073088 |
| Sen_G_0705 | PIK3CA | 5290 | MME | Upregulation | Unclear | PI3K-AKT-MTOR | -- | protein coding | MCF 10A/H | -- | Breast cancer | Accelerate | | HL | 30671946 |
| Sen_G_0706 | ATF1 | 466 | -- | -- | Unclear | -- | -- | protein coding | Sarcoma-iPSC MEF | -- | Clear cell sarcoma | Accelerate | | HL | 31488818 |
| Sen_G_0707 | SERTAD1 | 29950 | -- | -- | Ubiquitylation | -- | -- | protein coding | MCF-7 | -- | Aging | Prevent | | L | 19903772 |
| Sen_G_0708 | NPM1 | 4869 | P53 | Upregulation | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 12080348 |
| Sen_G_0709 | MDM2 | 4193 | -- | -- | Unclear | -- | -- | protein coding | LS8817 | -- | Cancer | Prevent | | L | 25803170 |
| Sen_G_0710 | ID1 | 3397 | -- | -- | Unclear | -- | -- | protein coding | PC-3 | -- | Prostate cancer | Prevent | | L | 20881502 |
| Sen_G_0711 | NF1 | 4763 | -- | -- | Unclear | PI3K-AKT-MTOR | -- | protein coding | -- | Mice ear | Melanoma | Accelerate | | L | 23171796 |
| Sen_G_0712 | ICMT | 23463 | PRELAMIN A | Inhibition | Unclear | AKT-MTOR | -- | protein coding | Fibroblast | -- | Hutchinson-Gilford progeria syndrome | Accelerate | | L | 23686339 |
| Sen_G_0713 | SIRT1 | 23411 | PAI-1 | Downregulation | Binding to promoter Acetylation | -- | -- | protein coding | HUVEC | -- | Atherosclerosis | Prevent | | L | 25040736 |
| Sen_G_0714 | SERPINE1 | 5054 | -- | -- | Binding to promoter Acetylation | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 25040736 |
| Sen_G_0715 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | C6 | -- | Aging | Accelerate | | L | 11983028 |
| Sen_G_0716 | DUSP16 | 80824 | RB | -- | Unclear | P53 | -- | protein coding | PLC-PRF-5 | -- | Aging | Prevent | | HL | 26381291 |
| Sen_G_0717 | RAPGEF4 | 11069 | CRT | Inhibition | Unclear | -- | -- | protein coding | ESC | -- | Decidualization of Human Endometrial Stromal Cell | Prevent | | L | 24169561 |
| Sen_G_0718 | CALR | 811 | -- | -- | Unclear | -- | -- | protein coding | ESC | -- | Decidualization of Human Endometrial Stromal Cell | Prevent | | L | 24169561 |
| Sen_G_0719 | CEBPB | 1051 | -- | -- | Unclear | -- | -- | protein coding | PB-TRE,PB-CEBPB,LNCaP-shNTV | -- | Prostate cancer | Accelerate | | HL | 25772238 |
| Sen_G_0720 | JPT1 | 51155 | -- | -- | Unclear | -- | -- | protein coding | A549,HUVEC | -- | Cancer | Prevent | | HL | 31257225 |
| Sen_G_0721 | HNRNPA1 | 3178 | HN1-L | -- | Unclear | -- | -- | protein coding | HUVEC,A549 | -- | Cancer | Prevent | | HL | 31257225 |
| Sen_G_0722 | MYC | 4609 | WRN | Upregulation | Unclear | -- | -- | protein coding | hTERT-immortalized WRN?/? Fibroblast strains AG00780,hTERT-immortalized WRN?/? Fibroblast strains AG03141 | -- | Aging | Accelerate | | HL | 12842909 |
| Sen_G_0723 | WRN | 7486 | -- | -- | Unclear | -- | -- | protein coding | hTERT+ Fibroblast | -- | Aging | Prevent | | HL | 12842909 |
| Sen_G_0723 | WRN | 7486 | -- | -- | Unclear | -- | -- | protein coding | hTERT+ Fibroblast | -- | Aging | Prevent | | HL | 12842909 |
| Sen_G_0724 | CHEK2 | 11200 | -- | -- | Unclear | -- | -- | protein coding | BJ,Fibroblast,iG4 Terc?/?Fibroblast | Colon | Telomere dysfunction | Accelerate | | L | 20577265 |
| Sen_G_0725 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HSC | -- | Aging | Accelerate | | L | 30962418 |
| Sen_G_0726 | FASN | 2194 | -- | -- | Unclear | MTOR | -- | protein coding | HSC | -- | Aging | Accelerate | | L | 30962418 |
| Sen_G_0727 | TRPM7 | 54822 | WRN | -- | Unclear | -- | -- | protein coding | BxPC-3,PANC-1 | -- | Pancreatic cancer | Prevent | | L | 22166235 |
| Sen_G_0728 | HMGB2 | 3148 | C/EBP-β | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 27799366 |
| Sen_G_0729 | SMARCD1 | 6602 | -- | -- | Unclear | -- | -- | protein coding | TIG-1,Hepatocyte,Hepatocyte | -- | Aging | Prevent | | L | 28868154 |
| Sen_G_0730 | HSP90AA1 | 3320 | P14 | -- | Unclear | -- | -- | protein coding | IMR-90,HFF | -- | Lung cancer | Prevent | | HL | 27793846 |
| Sen_G_0731 | HSP90B1 | 7184 | P14 | -- | Unclear | -- | -- | protein coding | IMR-90,HFF | -- | Lung cancer | Prevent | | HL | 27793846 |
| Sen_G_0732 | SIRT6 | 51548 | -- | -- | Unclear | P21 | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 23201774 |
| Sen_G_0733 | MIF | 4282 | BECLIN1//LC3-I/II//P62 | Upregulation//Upregulation//Downregulation | Unclear | -- | -- | protein coding | MSC | -- | Myocardial infarction | Prevent | | L | 31881006 |
| Sen_G_0734 | ZBTB48 | 3104 | -- | -- | Unclear | P53 | Upregulation | protein coding | pMSC | -- | Aging | Accelerate | | HL | 30845965 |
| Sen_G_0735 | NFATC1 | 4772 | -- | -- | Unclear | PTEN-AKT | Activation | protein coding | prostate epithelial cell | -- | Prostate cancer | Prevent | | HL | 26477312 |
| Sen_G_0736 | MAD2L1 | 4085 | -- | -- | Unclear | -- | -- | protein coding | MKN45 | -- | Gastric cancer | Prevent | | L | 25483095 |
| Sen_G_0737 | BUB1B | 701 | -- | -- | Unclear | -- | -- | protein coding | MKN45 | -- | Gastric cancer | Prevent | | L | 25483095 |
| Sen_G_0738 | NUPR1 | 26471 | -- | -- | Unclear | -- | -- | protein coding | A549,H460 | -- | Lung cancer | Prevent | | HL | 29130426 |
| Sen_G_0739 | HRAS | 3265 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Cancer | Accelerate | | HL | 24618719 |
| Sen_G_0740 | CUX1 | 1523 | OGG1 | Activation | Unclear | -- | -- | protein coding | IMR-90 | -- | Cancer | Prevent | | HL | 24618719 |
| Sen_G_0741 | ASXL1 | 171023 | E2F//EZH2 | --//-- | Unclear | AKT-E2F | -- | protein coding | MEF | -- | Aging | Prevent | | HL | 28701722 |
| Sen_G_0742 | RELA | 5970 | CXCL1 | -- | Unclear | -- | -- | protein coding | Human low-grade PanIN cell | Pancreata | Pancreatic ductal adenocarcinoma | Accelerate | | HL | 27454298 |
| Sen_G_0743 | NTN4 | 59277 | -- | -- | Unclear | -- | -- | protein coding | U251MG,pcDNA3 | -- | Glioblastoma | Prevent | | HL | 30514230 |
| Sen_G_0744 | EGF | 1950 | NTN4 | Upregulation | Unclear | -- | -- | protein coding | U251MG | -- | Glioblastoma | Prevent | | HL | 30514230 |
| Sen_G_0745 | COPS5 | 10987 | -- | -- | Unclear | PI3K-AKT | -- | protein coding | MEF | -- | Cancer | Prevent | | L | 23127558 |
| Sen_G_0746 | CNOT6 | 57472 | IGFBP5 | -- | Unclear | P53 | -- | protein coding | MCF-7 | -- | Aging | Prevent | | HL | 21233283 |
| Sen_G_0747 | CNOT6L | 246175 | IGFBP5 | -- | Unclear | P53 | -- | protein coding | MCF-7 | -- | Aging | Prevent | | HL | 21233283 |
| Sen_G_0748 | RBM38 | 55544 | -- | -- | Unclear | P53 | Downregulation | protein coding | MEF | -- | Lymphoma | Prevent | | L | 21764855 |
| Sen_G_0749 | PYGL | 5836 | -- | -- | Unclear | P53 | -- | protein coding | U87 | -- | Cancer | Prevent | | L | 23177934 |
| Sen_G_0750 | ENO1 | 2023 | -- | -- | Unclear | -- | -- | protein coding | CFPAC-1 | -- | Pancreatic cancer | Prevent | | L | 26734996 |
| Sen_G_0751 | NCOA4 | 8031 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | | L | 24910095 |
| Sen_G_0752 | KLF6 | 1316 | -- | -- | Unclear | NF-κB | Downregulation | protein coding | LN-229,BTSC233 | -- | Glioblastoma | Accelerate | | HL | 28166199 |
| Sen_G_0753 | ABI3BP | 25890 | -- | -- | Methylation | -- | -- | protein coding | GBC | -- | Gallbladder cancer | Accelerate | | HL | 31174563 |
| Sen_G_0753 | ABI3BP | 25890 | -- | -- | Methylation | -- | -- | protein coding | GBC | -- | Gallbladder cancer | Accelerate | | HL | 31174563 |
| Sen_G_0754 | ATM | 472 | B56γ2 | Inhibition | Ubiquitylation | CHK1-P53-P21 | -- | protein coding | DLD1,HCT116 | -- | Colorectal cancer | Prevent | | HL | 28093285 |
| Sen_G_0755 | ASAH1 | 427 | -- | -- | Unclear | -- | -- | protein coding | A375 | -- | Melanoma | Prevent | | L | 28785021 |
| Sen_G_0756 | RHEB | 6009 | COL2A1//SOX9 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | Articular Chondrocyte | Bone | Osteoarthritis | Prevent | | L | 31229684 |
| Sen_G_0757 | AGER | 177 | -- | -- | Unclear | -- | -- | protein coding | -- | Lung | Aging | Prevent | | L | 28977635 |
| Sen_G_0758 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | ECFC | -- | Preterm | Prevent | | L | 24518759 |
| Sen_G_0759 | FGF21 | 26291 | P21//TRF2 | Downregulation//Upregulation | Unclear | P53//SIAH-1//AMPK | Downregulation//Downregulation//Activation | protein coding | BVSMC | -- | Cerebrovascular aging | Prevent | | L | 27364911 |
| Sen_G_0760 | SIRT1 | 23411 | FOXO3//P21 | --//-- | Unclear | -- | -- | protein coding | Clara | Lung | Chronic obstructive pulmonary disease | Prevent | | L | 22546858 |
| Sen_G_0761 | IHH | 3549 | -- | -- | Unclear | ROS-MTOR-4EBP1 | Downregulation//-- | protein coding | B-MSC | -- | Aging | Prevent | | L | 32235006 |
| Sen_G_0762 | NAMPT | 10135 | -- | -- | Unclear | -- | -- | protein coding | Adipose stromal cell | Adipose | Aging | Prevent | | L | 31204283 |
| Sen_G_0763 | CALCA | 796 | KLOTHO | Upregulation | Unclear | -- | -- | protein coding | EPC | Blood | Aging | Prevent | | HL | 20832068 |
| Sen_G_0764 | ATG7 | 10533 | P53//P21//CDK1//H2AX | --//--//--//-- | Unclear | -- | -- | protein coding | keratinocyte | Skin | Aging | Prevent | | HL | 28012437 |
| Sen_G_0765 | FOXQ1 | 94234 | -- | -- | Unclear | -- | -- | protein coding | HUCMSC | Umbilical cord | Alzheimer's disease | Prevent | | L | 29500491 |
| Sen_G_0766 | KNDC1 | 85442 | -- | -- | Unclear | P53 | Upregulation | protein coding | HUVEC | Umbilical cord | Aging | Accelerate | | L | 29568929 |
| Sen_G_0767 | FOXO3 | 2309 | C-MYC//HTERT | Upregulation//Upregulation | Binding to promoter | -- | -- | protein coding | HUC-F2 | -- | Aging | Prevent | | L | 25000517 |
| Sen_G_0768 | CCN1 | 3491 | IL-1β | Upregulation | Unclear | -- | -- | protein coding | -- | Skin | Aging | Accelerate | | L | 23881607 |
| Sen_G_0769 | TRIM28 | 10155 | P16 | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 25160591 |
| Sen_G_0770 | ARG2 | 384 | ENOS | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 22928666 |
| Sen_G_0771 | RPS6KB1 | 6198 | ARG-II | Upregulation | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | | L | 22928666 |
| Sen_G_0772 | JUND | 3727 | P47PHOX//NOX2//NOX4 | --//--//-- | Unclear | -- | -- | protein coding | Aortic endothelial cell | Aorta | Aging | Prevent | | L | 23410942 |
| Sen_G_0773 | IGF1 | 3479 | -- | -- | Unclear | SIRT1-P53 | Activation | protein coding | MCF-7,IMR-90 | -- | Aging | Accelerate | | L | 25070626 |
| Sen_G_0774 | SIRT6 | 51548 | PARP1 | Inhibition | Unclear | -- | -- | protein coding | HCA2 | -- | Aging | Prevent | | L | 22753495 |
| Sen_G_0775 | SIRT1 | 23411 | P16 | -- | Unclear | -- | -- | protein coding | B-MSC,A-MSC | Bone and Adipose | Aging | Prevent | | L | 22038097 |
| Sen_G_0776 | PTEN | 5728 | -- | -- | Methylation | PI3K-AKT//CYCLIN D1-E2F-EZH2-P16 | Downregulation//-- | protein coding | -- | Human islet | Aging | Accelerate | | L | 23826727 |
| Sen_G_0777 | RECQL4 | 9401 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Mouse tail | Rothmund–Thomson syndrome | Prevent | | HL | 24832598 |
| Sen_G_0778 | E2F1 | 1869 | FOXO3 | Downregulation | Unclear | -- | -- | protein coding | MEF | Embryo | Aging | Accelerate | | L | 25344604 |
| Sen_G_0779 | E2 | 1489080 | -- | -- | Unclear | -- | -- | protein coding | HeLa | -- | Aging | Accelerate | | HL | 16626397 |
| Sen_G_0780 | IGF1 | 3479 | -- | -- | Phosphorylation | PI3K-AKT | Activation | protein coding | Myocyte | -- | Cardiomyopathy and heart failure | Prevent | | L | 14726476 |
| Sen_G_0781 | UBE2I | 7329 | PML | -- | Unclear | -- | -- | protein coding | U2OS | -- | Aging | Prevent | | L | 29773808 |
| Sen_G_0782 | HGF | 3082 | RAD51 | Upregulation | Unclear | -- | -- | protein coding | hE-MSC,BM-MSC | -- | Liver disease | Prevent | | L | 29398486 |
| Sen_G_0783 | MCL1 | 4170 | NOX4 | Downregulation | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Prevent | | L | 28423654 |
| Sen_G_0784 | MAPK1 | 5594 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Prostate cancer | Accelerate | | HL | 23599344 |
| Sen_G_0785 | SOD2 | 6648 | -- | -- | Unclear | -- | -- | protein coding | Chondrocyte | Bone | Cartilage degeneration | Prevent | | L | 26108578 |
| Sen_G_0786 | LMNA | 4000 | -- | -- | Unclear | -- | -- | protein coding | -- | Embryo | Aging | Prevent | | L | 21479207 |
| Sen_G_0787 | SOD3 | 6649 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Skin | Aging | Prevent | | HL | 25927599 |
| Sen_G_0788 | DKC1 | 1736 | -- | -- | Unclear | -- | -- | protein coding | MEF | Embryo | X-linked dyskeratosis congenita | Prevent | | L | 21241452 |
| Sen_G_0789 | IRS2 | 8660 | FOXO1 | -- | Unclear | -- | -- | protein coding | Astrocyte | Brain | Huntington disease | Accelerate | | L | 21926467 |
| Sen_G_0790 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Tumor | Accelerate | | L | 18089799 |
| Sen_G_0791 | ING1 | 3621 | -- | -- | Unclear | P16-PRB | Activation | protein coding | Hs68 | -- | Aging | Accelerate | | L | 18691180 |
| Sen_G_0792 | PTEN | 5728 | -- | -- | Unclear | P27 | Upregulation | protein coding | BM-MSC | -- | Systemic Lupus Erythematosus | Accelerate | | L | 25649549 |
| Sen_G_0793 | BTK | 695 | -- | -- | Phosphorylation | P53 | Activation | protein coding | EJp53,HDF | -- | Aging | Accelerate | | L | 27630139 |
| Sen_G_0794 | KRT24 | 192666 | -- | -- | Unclear | -- | -- | protein coding | Primary human epidermal keratinocyte | Skin | Aging | Accelerate | | L | 28362807 |
| Sen_G_0795 | DLK1 | 8788 | -- | -- | Unclear | ERK//P53-P21 | --//-- | protein coding | WI-38 | -- | Aging | Prevent | | L | 21893036 |
| Sen_G_0796 | SAE2 | 816686 | -- | -- | Unclear | SUMO | Activation | protein coding | HCT116,U2OS | -- | Cancer | Prevent | | L | 25860128 |
| Sen_G_0797 | IFNG | 3458 | P21/WAF1 | Upregulation | Unclear | JAK2-STAT1 | -- | protein coding | Melanocyte | -- | Vitiligo | Accelerate | | L | 24681574 |
| Sen_G_0798 | CTSK | 1513 | -- | -- | Unclear | -- | -- | protein coding | MEF,NHDF | -- | Aging | Prevent | | L | 21616554 |
| Sen_G_0799 | MDM2 | 4193 | P53//P21 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | H460 | -- | Lung cancer | Prevent | | L | 16093429 |
| Sen_G_0800 | CDKN1C | 1028 | -- | -- | Unclear | HES1 | -- | protein coding | HepG2,SNU398 HCC | -- | Hepatocellular carcinoma | Accelerate | | L | 22705236 |
| Sen_G_0801 | SPHK2 | 56848 | -- | -- | Unclear | P16 | -- | protein coding | -- | Spleen,Skin,Testes tissue | Lung cancer | Prevent | | HL | 29748384 |
| Sen_G_0802 | GKN1 | 56287 | C-MYC//HTERT//TRF1 | Downregulation//Downregulation//Upregulation | Unclear | -- | -- | protein coding | AGS,MKN1,AGSGKN1,MKN1GKN1 | -- | Gastric cancer | Accelerate | | L | 25344918 |
| Sen_G_0803 | PAPSS2 | 9060 | -- | -- | Unclear | FGFR-AKT-P53-P21 | -- | protein coding | MCF-7 | Tumor tissue | Breast cancer | Prevent | | HL | 26250908 |
| Sen_G_0804 | PTEN | 5728 | -- | -- | Unclear | AKT-ROS-P53-P21 | -- | protein coding | LN-18,U87,U251,U373,LN428 | -- | Glioma | Prevent | | L | 21072054 |
| Sen_G_0805 | UBTD1 | 80019 | -- | -- | Unclear | MDM2-P53 | Downregulation | protein coding | HDF,MKN45 | Tumor tissue | Gastric cancer | Accelerate | | HL | 25382750 |
| Sen_G_0806 | RBX1 | 9978 | -- | -- | Unclear | -- | -- | protein coding | U87,H1299 | -- | Cancer | Prevent | | L | 19509229 |
| Sen_G_0807 | CYP24A1 | 1591 | -- | -- | Unclear | -- | -- | protein coding | Primary renal proximal tubule epithelial cell | Kidney | Diabetes | Accelerate | | L | 23119081 |
| Sen_G_0808 | TERT | 7015 | -- | -- | Unclear | PI3K-AKT | Upregulation | protein coding | MSC | -- | Aging | Prevent | | HL | 26178664 |
| Sen_G_0809 | BMP7 | 655 | HTERT | Downregulation | Unclear | SMAD3 | -- | protein coding | MCF-7 | -- | Breast cancer | Accelerate | | L | 27696331 |
| Sen_G_0810 | BRD7 | 29117 | P21//P53 | Upregulation//-- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Accelerate | | HL | 20660729 |
| Sen_G_0811 | MAPK8 | 5599 | -- | -- | Phosphorylation | BCL-2-ROS-DDR | Activation | protein coding | MCF-7 | -- | Lung cancer | Prevent | | L | 19855432 |
| Sen_G_0812 | GAS2 | 2620 | P53//P21 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | SK-HEP-1 | -- | Hepatocellular carcinoma | Accelerate | | HL | 25925944 |
| Sen_G_0813 | FASLG | 356 | CASPASE | Activation | Unclear | P53 | -- | protein coding | CRC29 | -- | Colorectal cancer | Accelerate | | HL | 28300842 |
| Sen_G_0814 | KRAS | 3845 | -- | -- | Unclear | -- | -- | protein coding | L13 | -- | Colorectal cancer | Prevent | | HL | 28300842 |
| Sen_G_0815 | SIRT7 | 51547 | P53 | Downregulation | Unclear | -- | -- | protein coding | NIH-3T3,U2OS | -- | Aging | Prevent | | L | 25445786 |
| Sen_G_0816 | ERBB2 | 2064 | TBK1 | Downregulation | Unclear | CGAS-STING | Downregulation | protein coding | DLD1 | -- | Melanoma | Prevent | | L | 31332347 |
| Sen_G_0817 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 28120917 |
| Sen_G_0818 | RELA | 5970 | -- | -- | Phosphorylation | P16 | Upregulation | protein coding | HCT116,HCT116 p53-/-,MCF-7 | -- | Cancer | Accelerate | | HL | 26375985 |
| Sen_G_0819 | TFEB | 7942 | -- | -- | Unclear | -- | -- | protein coding | Primary mice Chondrocyte,Primary human Chondrocyte | -- | Osteoarthritis | Prevent | | L | 30154423 |
| Sen_G_0820 | BUB1 | 699 | -- | -- | Unclear | CDKN2A-RB1//P53-CDKN1A | --//-- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 27731420 |
| Sen_G_0821 | SMC1A | 8243 | -- | -- | Unclear | CDKN2A-RB1//TP53-CDKN1A | --//-- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 27731420 |
| Sen_G_0822 | DNAJA4 | 55466 | -- | -- | Unclear | NF-κB | -- | protein coding | HaCaT | -- | Aging | Prevent | | L | 29807809 |
| Sen_G_0823 | G6PD | 2539 | -- | -- | Unclear | -- | -- | protein coding | HCC,G6PD,HCT116 | -- | Colorectal cancer | Prevent | | L | 24352616 |
| Sen_G_0824 | MTDH | 92140 | -- | -- | Unclear | -- | -- | protein coding | LNCaP,C4-2B | -- | Prostate cancer | Prevent | | L | 28923415 |
| Sen_G_0825 | BMI1 | 648 | γ-H2AX//PCHK2//P16//P19//P53//P21 | --//--//--//--//--//-- | Unclear | -- | -- | protein coding | -- | Kidney | Renal tubulointerstitial injury | Prevent | | L | 24915841 |
| Sen_G_0826 | PMAIP1 | 5366 | -- | -- | Unclear | -- | -- | protein coding | H460 | -- | Lungcancer | Prevent | | L | 24853380 |
| Sen_G_0827 | RBM38 | 55544 | P53//MDM2 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | SMMC-7721,HepG2 | -- | Hepatocellular carcinoma | Accelerate | | L | 30176896 |
| Sen_G_0828 | TFEB | 7942 | -- | -- | Unclear | -- | -- | protein coding | BEAS-2B | Lung | Chronic obstructive pulmonary disease | Prevent | | L | 27835930 |
| Sen_G_0829 | TFDP1 | 7027 | -- | -- | Unclear | P53//P21 | --//-- | protein coding | HeLa,A549,WI-38,Saos-2 | -- | Cervical cancer | Prevent | | HL | 22012588 |
| Sen_G_0830 | BRCA1 | 672 | -- | -- | Unclear | -- | -- | protein coding | HBLpS,MCF-7pS,HBLpS-BR,MCF-7pS-BR,HCC1937,HCC+BR | -- | Breast cancer | Prevent | | L | 19372557 |
| Sen_G_0831 | KDR | 3791 | -- | -- | Unclear | -- | -- | protein coding | U373 MG | -- | Glioblastoma | Prevent | | L | 26420897 |
| Sen_G_0832 | SOCS1 | 8651 | P53 | Activation | Phosphorylation | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | HL | 20005840 |
| Sen_G_0833 | MECP2 | 4204 | -- | -- | Unclear | RB//P53 | --//-- | protein coding | MSC | -- | Aging | Prevent | | HL | 20065150 |
| Sen_G_0834 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Prevent | | L | 25924011 |
| Sen_G_0835 | SIRT2 | 22933 | -- | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Prevent | | L | 25924011 |
| Sen_G_0836 | RUNX1 | 861 | -- | -- | Unclear | -- | -- | protein coding | AML | -- | Acute leukemia | Prevent | | L | 15298716 |
| Sen_G_0837 | RUNX1T1 | 862 | -- | -- | Unclear | -- | -- | protein coding | AML | -- | Acute leukemia | Prevent | | L | 15298716 |
| Sen_G_0838 | ZEB1 | 6935 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Prevent | | L | 21527937 |
| Sen_G_0839 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HN 30,HN 31 | -- | Squamous cell carcinoma | Prevent | | L | 22090360 |
| Sen_G_0840 | ILK | 3611 | RB | -- | Unclear | -- | -- | protein coding | Rb116,Y79 | -- | Human retinoblastoma | Prevent | | L | 26176204 |
| Sen_G_0841 | IL6 | 3569 | -- | -- | Unclear | JAK1-STAT3 | Activation | protein coding | HCT116 | -- | Tumor | Prevent | | L | 22521547 |
| Sen_G_0842 | NGF | 4803 | P27//P21//CYCLIN D1//P53//P16 //RB | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Downregulation | Phosphorylation | NF-κB | Activation | protein coding | Res 186,Res 259,U87,A172 | -- | Glioma | Accelerate | | L | 30417351 |
| Sen_G_0843 | TRIM32 | 22954 | P53 | Downregulation | Binding to promoter Ubiquitylation | -- | -- | protein coding | HCT116 p53+/+,HCT116 p53-/- | -- | Tumor | Prevent | | L | 25146927 |
| Sen_G_0844 | EPO | 2056 | -- | -- | Unclear | -- | -- | protein coding | DA3/EPOR | -- | Leukemia | Accelerate | | L | 30622244 |
| Sen_G_0845 | HRAS | 3265 | GAPDH | Downregulation | Unclear | -- | -- | protein coding | HuDE | -- | Aging | Accelerate | | L | 23284910 |
| Sen_G_0846 | NUDT5 | 11164 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 23581889 |
| Sen_G_0847 | PDZD2 | 23037 | P21/WAF1 | Upregulation | Unclear | P53 | Upregulation | protein coding | DU 145 | -- | Prostate cancer | Accelerate | | L | 18639375 |
| Sen_G_0848 | BCL2L12 | 83596 | -- | -- | Unclear | P53 | Downregulation | protein coding | MEF | -- | Glioblastoma | Prevent | | L | 20837658 |
| Sen_G_0849 | HIF1A | 3091 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 28552779 |
| Sen_G_0850 | TWIST1 | 7291 | -- | -- | Unclear | -- | -- | protein coding | H460,A549,H358,H727,Calu-1,Calu-6,H1975 | -- | Lung cancer | Prevent | | HL | 23364532 |
| Sen_G_0851 | RACK1 | 10399 | -- | -- | Unclear | -- | -- | protein coding | CaSki | -- | Cervical cancer | Prevent | | L | 29048616 |
| Sen_G_0852 | POT1 | 25913 | TRF2 | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 15657433 |
| Sen_G_0853 | TERF2 | 7014 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | | L | 15657433 |
| Sen_G_0854 | TMSB4X | 7114 | -- | -- | Unclear | -- | -- | protein coding | Nucleus pulposus cell | Nucleus pulposus tissue | Aging | Prevent | | L | 26021512 |
| Sen_G_0855 | PIM1 | 5292 | P53//P16//NS | Downregulation//Downregulation//Upregulation | Unclear | -- | -- | protein coding | hCPC | Heart left ventricle | Heart failure | Prevent | | HL | 25882843 |
| Sen_G_0856 | TERF2 | 7014 | P21//P53 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | SH-SY5Y | -- | Neuroblastoma | Prevent | | L | 16539655 |
| Sen_G_0857 | KDM4B | 23030 | -- | -- | Unclear | STAT3 | -- | protein coding | HCT116,SW480 | -- | Colorectal cancer | Prevent | | HL | 24473398 |
| Sen_G_0858 | VASH1 | 22846 | -- | -- | Unclear | -- | -- | protein coding | HT29 | -- | Colorectal cancer | Accelerate | | L | 25797264 |
| Sen_G_0859 | CDK2AP1 | 8099 | P53//P21//BAX//PUMA | --//--//--//-- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | | L | 25785833 |
| Sen_G_0860 | PLA2R1 | 22925 | -- | -- | Unclear | -- | -- | protein coding | HMEC | -- | Breast cancer | Accelerate | | L | 23994771 |
| Sen_G_0861 | GPC3 | 2719 | TGF-β2 | -- | Unclear | -- | -- | protein coding | HuH-7,HepG2 | -- | Hepatocellular carcinoma | Prevent | | HL | 21847365 |
| Sen_G_0862 | TGFB2 | 7042 | CYCLIN A//CYCLIN D1//RB//P15INK4B//P21//BCL-XL//MCL-1//BCL-2 | Downregulation//Downregulation//Downregulation//Upregulation//Upregulation//Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | HuH-7 | -- | Hepatocellular carcinoma | Accelerate | | HL | 21847365 |
| Sen_G_0863 | ERBB4 | 2066 | PERK//P21//P27 | --//--//-- | Unclear | -- | -- | protein coding | Saos-2,MG63.2 | -- | Osteosarcoma | Prevent | | HL | 29524631 |
| Sen_G_0864 | SOD1 | 6647 | -- | -- | Unclear | -- | -- | protein coding | Mammary epithelial cell | Mammary Gland | Breast cancer | Prevent | | L | 31222103 |
| Sen_G_0865 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | A549 | -- | Idiopathic pulmonary fibrosis | Prevent | | L | 27979858 |
| Sen_G_0866 | ZBTB7A | 51341 | -- | -- | Unclear | -- | -- | protein coding | U87 MG | -- | Glioma | Prevent | | L | 25875864 |
| Sen_G_0867 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HSC-1 | -- | Skin cancer | Accelerate | | L | 19009304 |
| Sen_G_0868 | AKAP4 | 8852 | -- | -- | Unclear | -- | -- | protein coding | COLO 205 ,HCT116 | -- | Colorectal cancer | Prevent | | L | 26590805 |
| Sen_G_0869 | POT1 | 25913 | -- | -- | Unclear | -- | -- | protein coding | BGC-823 | -- | Gastric cancer | Prevent | | HL | 20517159 |
| Sen_G_0870 | PPP1R13L | 10848 | -- | -- | Unclear | -- | -- | protein coding | OCCC,OVTOKO,KK | -- | Ovarian cancer | Prevent | | L | 29663364 |
| Sen_G_0871 | BTG1 | 694 | -- | -- | Unclear | -- | -- | protein coding | HCT-15,HCT116 | -- | Colorectal cancer | Accelerate | | HL | 27447746 |
| Sen_G_0872 | DEK | 7913 | -- | -- | Unclear | -- | -- | protein coding | Melanocyte,SK-Mel-28,SK-Mel-94,G-361,UACC-62,UACC-257,MM576 | -- | Melanoma | Prevent | | HL | 19679545 |
| Sen_G_0873 | RHEB | 6009 | P53//MTORC1 | --//-- | Unclear | -- | -- | protein coding | MEF | -- | Lymphoma | Accelerate | | L | 18708578 |
| Sen_G_0874 | BRAF | 673 | -- | -- | Unclear | -- | -- | protein coding | Melanocyte | -- | Melanoma | Accelerate | | HL | 19805117 |
| Sen_G_0875 | TYRO3 | 7301 | -- | -- | Unclear | -- | -- | protein coding | Melanocyte | -- | Melanoma | Prevent | | HL | 19805117 |
| Sen_G_0876 | TIGAR | 57103 | -- | -- | Unclear | -- | -- | protein coding | OVCA420 | -- | Ovarian cancer | Prevent | | HL | 31508509 |
| Sen_G_0877 | GRB2 | 2885 | -- | -- | Unclear | -- | -- | protein coding | H1299,SPCA1 | -- | Lung cancer | Prevent | | L | 30069987 |
| Sen_G_0878 | ZBTB7A | 51341 | P53//P21 | --//-- | Unclear | -- | -- | protein coding | FS090,SW 13 53 | -- | Chondrosarcoma | Prevent | | HL | 22847180 |
| Sen_G_0879 | TBPL1 | 9519 | P53 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | | L | 28082682 |
| Sen_G_0880 | YAP1 | 10413 | -- | -- | Unclear | -- | -- | protein coding | A549 | -- | Lung cancer | Prevent | | L | 27903989 |
| Sen_G_0881 | TEAD2 | 8463 | -- | -- | Unclear | -- | -- | protein coding | A549 | -- | Lung cancer | Prevent | | L | 27903989 |
| Sen_G_0882 | DDX24 | 57062 | P53 | -- | Unclear | -- | -- | protein coding | U2OS | -- | Cancer | Prevent | | L | 25867071 |
| Sen_G_0883 | MAPK1 | 5594 | -- | -- | Unclear | -- | -- | protein coding | EC109,EC109/CDDP | -- | Esophageal cancer | Accelerate | | L | 25236911 |
| Sen_G_0884 | POT1 | 25913 | -- | -- | Unclear | -- | -- | protein coding | HT-1080,IMR-90 | -- | Aging | Prevent | | L | 15620654 |
| Sen_G_0885 | RING1 | 6015 | P53 | -- | Unclear | -- | -- | protein coding | HepG2,HCT116 | -- | Hepatocellular carcinoma | Prevent | | HL | 29187402 |
| Sen_G_0886 | RANBP9 | 10048 | -- | -- | Unclear | -- | -- | protein coding | A549,H460 | -- | Lung cancer | Prevent | | L | 26943034 |
| Sen_G_0887 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | Saos-2 | -- | Cancer | Accelerate | | HL | 26278998 |
| Sen_G_0888 | IFITM3 | 10410 | -- | -- | Phosphorylation | CCND1-CDK4-PRB | Upregulation | protein coding | ORL-150,ORL-204 | Human OSCC primary tumour | Oral cancer | Prevent | | L | 30949979 |
| Sen_G_0889 | SIRT3 | 23410 | -- | -- | Unclear | -- | -- | protein coding | Nucleus pulposus cell | Nucleus pulposus tissue | Disc degenerative disease | Prevent | | L | 30420619 |
| Sen_G_0890 | BECN1 | 8678 | -- | -- | Unclear | -- | -- | protein coding | U87 | -- | Glioma | Prevent | | HL | 29991800 |
| Sen_G_0891 | KDM2B | 84678 | -- | -- | Unclear | -- | -- | protein coding | MDA-MB-231,T47D,MCF-7 | -- | Breast cancer | Prevent | | L | 24853546 |
| Sen_G_0892 | TP63 | 8626 | -- | -- | Unclear | -- | -- | protein coding | keratinocyte,JHU-011,JHU-029 | Foreskin | Skin cancer | Prevent | | L | 17018588 |
| Sen_G_0893 | BECN1 | 8678 | -- | -- | Unclear | -- | -- | protein coding | HT22 | -- | Aging | Prevent | | L | 30807795 |
| Sen_G_0894 | EP400 | 57634 | ATM | -- | Unclear | -- | -- | protein coding | U2OS,IMR-90 | -- | Aging | Prevent | | HL | 20548951 |
| Sen_G_0895 | SRC | 6714 | P21 | -- | Unclear | -- | -- | protein coding | HT-1080 | -- | Aging | Prevent | | L | 16204065 |
| Sen_G_0896 | IL22 | 50616 | STAT3//P53//SOCS3 | Activation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | HSC | Liver | Liver disease | Accelerate | | L | 22473749 |
| Sen_G_0897 | PRMT5 | 10419 | P53//P21//RB | --//--// -- | Unclear | -- | -- | protein coding | GBMNS | Brain | Glioblastoma | Prevent | | HL | 27292259 |
| Sen_G_0898 | PTEN | 5728 | -- | -- | Unclear | -- | -- | protein coding | GBMNS | Brain | Glioblastoma | Accelerate | | HL | 27292259 |
| Sen_G_0899 | RB1 | 5925 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Retinoblastoma | Prevent | | L | 27124644 |
| Sen_G_0900 | RBL1 | 5933 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Retinoblastoma | Prevent | | L | 27124644 |
| Sen_G_0901 | RBL2 | 5934 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Retinoblastoma | Accelerate | | L | 27124644 |
| Sen_G_0902 | GGCT | 79017 | -- | -- | Unclear | -- | -- | protein coding | PC-3 | -- | Prostate cancer | Prevent | | L | 31519583 |
| Sen_G_0903 | RASSF1 | 11186 | P21/WAF1 | Upregulation | Unclear | -- | -- | protein coding | A549 | Tumor tissue | Colorectal cancer | Accelerate | | L | 19223555 |
| Sen_G_0904 | CLU | 1191 | -- | -- | Unclear | -- | -- | protein coding | -- | Lung | Idiopathic pulmonary fibrosis | Prevent | | HL | 29133960 |
| Sen_G_0905 | DAXX | 1616 | -- | -- | Unclear | P53-P21 | -- | protein coding | mOSE | -- | Ovarian cancer | Prevent | | HL | 23542781 |
| Sen_G_0906 | CSNK2A1 | 1457 | P53 | Upregulation | Unclear | -- | -- | protein coding | A172,U87 MG | -- | Glioblastoma | Accelerate | | HL | 22318540 |
| Sen_G_0907 | CSNK2B | 1460 | P53 | Upregulation | Unclear | -- | -- | protein coding | A172,U87 MG | -- | Glioblastoma | Accelerate | | HL | 22318540 |
| Sen_G_0908 | MAP2K7 | 5609 | -- | -- | Unclear | MDM2-P21 | -- | protein coding | MCF-7 | -- | Breast cancer | Prevent | | HL | 29768207 |
| Sen_G_0909 | MAPK1 | 5594 | -- | -- | Unclear | MDM2-P21 | -- | protein coding | MCF-7 | -- | Breast cancer | Prevent | | HL | 29768207 |
| Sen_G_0910 | BRD4 | 23476 | -- | -- | Unclear | -- | -- | protein coding | Mouse Fibroblast cell | -- | Aging | Prevent | | HL | 28854735 |
| Sen_G_0911 | HDAC4 | 9759 | -- | -- | Unclear | -- | -- | protein coding | U87 MG,U251MG | -- | Cancer | Prevent | | L | 28342984 |
| Sen_G_0912 | MYCN | 4613 | EZH2//P21 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | HEL,K562 | -- | Erythroleukemia | Prevent | | HL | 29022893 |
| Sen_G_0913 | CDKN2A | 1029 | -- | -- | Unclear | -- | -- | protein coding | NP-9,NP-18,NP-29,NP-31 | Tumor tissue tissue | Pancreatic cancer | Accelerate | | L | 11687897 |
| Sen_G_0914 | KRAS | 3845 | -- | -- | Unclear | -- | -- | protein coding | DLD1(KRAS wt/mut),DWT7(wt/-) | -- | Lung cancer | Accelerate | | L | 24648348 |
| Sen_G_0915 | SPRY4 | 81848 | -- | -- | Unclear | -- | -- | protein coding | SK-MEL-119NRAS* | Tumor tissue tissue | Melanoma | Accelerate | | HL | 30651601 |
| Sen_G_0916 | HSPA4 | 3308 | AKT | -- | Unclear | -- | -- | protein coding | TF1-L1FK clone A5 | -- | Aging | Prevent | | HL | 16076962 |
| Sen_G_0917 | HSPH1 | 10808 | AKT | -- | Unclear | -- | -- | protein coding | TF1-L1FK clone A5 | -- | Aging | Prevent | | HL | 16076962 |
| Sen_G_0918 | NBNC | 4683 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Nijmegen Breakage Syndrome | Prevent | | L | 22161642 |
| Sen_G_0919 | SRF | 6722 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Prostate | Prostatic Hyperplasia | Prevent | | HL | 23308381 |
| Sen_G_0920 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | SH-EP | -- | Neuroblastoma | Accelerate | | HL | 17974978 |
| Sen_G_0921 | KRAS | 3845 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Lung cancer | Accelerate | | L | 26028035 |
| Sen_G_0922 | BRAF | 673 | -- | -- | Unclear | -- | -- | protein coding | MEF | -- | Lung cancer | Accelerate | | L | 26028035 |
| Sen_G_0923 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | | L | 26099456 |
| Sen_G_0924 | IGF1 | 3479 | RAS | Activation | Unclear | -- | -- | protein coding | MSC | Bone | Aging | Accelerate | | L | 19177843 |
| Sen_G_0925 | TINF2 | 26277 | -- | -- | Unclear | -- | -- | protein coding | TIN2+/+,TIN2+/DC-cond,TIN2+/+ mTR-/-,TIN2+/DCmTR-/-MEF | Embryo | Dyskeratosis congenita | Prevent | | HL | 24449270 |
| Sen_G_0926 | NHEJ1 | 79840 | -- | -- | Unclear | -- | -- | protein coding | CD34+,293T | Blood | Aging | Prevent | | HL | 28369633 |
| Sen_G_0927 | TINF2 | 26277 | -- | -- | Unclear | -- | -- | protein coding | HeLa-S3 | -- | Aging | Accelerate | | L | 18443218 |
| Sen_G_0928 | ZNF365 | 22891 | P53 | -- | Unclear | -- | -- | protein coding | MEF | -- | Breast cancer | Prevent | | HL | 23776040 |
| Sen_G_0929 | MDC1 | 9656 | -- | -- | Unclear | ATM | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 17158742 |
| Sen_G_0930 | DCLRE1B | 64858 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 16730176 |
| Sen_G_0931 | RTEL1 | 51750 | -- | -- | Unclear | -- | -- | protein coding | LCL | -- | Hoyeraal–Hreidarsson syndrome | Prevent | | HL | 23959892 |
| Sen_G_0932 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Skin | Dyskeratosis congenita | Prevent | | L | 17381549 |
| Sen_G_0933 | TOP2A | 7153 | TIFS | Downregulation | Unclear | ALT | -- | protein coding | U2OS,HeLa | -- | Cancer | Prevent | | L | 25430478 |
| Sen_G_0934 | TERF2 | 7014 | -- | -- | Unclear | -- | -- | protein coding | HEp-2 | -- | Laryngeal cancer | Prevent | | L | 27726944 |
| Sen_G_0935 | RAD51 | 5888 | -- | -- | Unclear | -- | -- | protein coding | HEp-2 | -- | Laryngeal cancer | Prevent | | L | 27726944 |
| Sen_G_0936 | TERF2 | 7014 | -- | -- | Unclear | -- | -- | protein coding | HEp-2 | -- | Laryngeal cancer | Prevent | | L | 27726944 |
| Sen_G_0937 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | HEp-2 | -- | Laryngeal cancer | Prevent | | L | 27726944 |
| Sen_G_0938 | LMNA | 4000 | -- | -- | Unclear | -- | -- | protein coding | Jun-82 | -- | Hutchinson-Gilford progeria syndrome | Accelerate | | L | 17870066 |
| Sen_G_0939 | CGGBP1 | 8545 | -- | -- | Unclear | -- | -- | protein coding | 1064Sk | -- | Aging | Prevent | | L | 24196442 |
| Sen_G_0940 | BMP7 | 655 | HTERT//C-MYC | Downregulation//Downregulation | Unclear | -- | -- | protein coding | HeLa,PMC42 | -- | Cervical cancer | Accelerate | | L | 19010887 |
| Sen_G_0941 | TERF2 | 7014 | WRN | -- | Unclear | P53-P21 | Upregulation | protein coding | AG06814,GM00319,AG00780,AG03141 | -- | Werner syndrome | Accelerate | | L | 18212065 |
| Sen_G_0942 | PRDX1 | 5052 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | HL | 29773556 |
| Sen_G_0943 | NUDT1 | 4521 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | HL | 29773556 |
| Sen_G_0944 | SMC5 | 23137 | -- | -- | Unclear | -- | -- | protein coding | SUSM1 | -- | Aging | Prevent | | L | 17589526 |
| Sen_G_0945 | SMC6 | 79677 | -- | -- | Unclear | -- | -- | protein coding | SUSM1 | -- | Aging | Prevent | | L | 17589526 |
| Sen_G_0946 | BTG2 | 7832 | PIN1 | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Accelerate | | L | 20569234 |
| Sen_G_0947 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | Hs68 | -- | Aging | Accelerate | | L | 20569234 |
| Sen_G_0948 | CDKN1A | 1026 | -- | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Accelerate | | L | 20569234 |
| Sen_G_0949 | CHEK2 | 11200 | P21//RB//CYCLIN A | Downregulation//--//Upregulation | Phosphorylation | -- | -- | protein coding | HFF,IMR-90 | -- | Aging | Accelerate | | L | 15192702 |
| Sen_G_0950 | BRCA1 | 672 | CYCLIN A //SIRT1 | --//-- | Unclear | PRB | -- | protein coding | HMEC | Mammary Gland | Breast cancer | Prevent | | HL | 26106036 |
| Sen_G_0951 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | WS,Fibroblast | -- | Werner syndrome | Prevent | | HL | 24749076 |
| Sen_G_0952 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | WS,Fibroblast | -- | Werner syndrome | Accelerate | | HL | 24749076 |
| Sen_G_0953 | POT1 | 25913 | -- | -- | Unclear | -- | -- | protein coding | HFF,BJ | Foreskin | Aging | Prevent | | L | 18922974 |
| Sen_G_0954 | CDK4 | 1019 | P16//P53//P21 | Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | HMEC,keratinocyte | Mammary Gland | Aging | Prevent | | L | 12545164 |
| Sen_G_0955 | HLX | 3142 | INK4A | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 24067365 |
| Sen_G_0956 | TERT | 7015 | -- | -- | Unclear | P53-P21 | Downregulation | protein coding | DC,Fibroblast | Skin | Dyskeratosis congenita | Prevent | | L | 21087144 |
| Sen_G_0957 | FUNDC1 | 139341 | AMPK | Activation | Unclear | -- | -- | protein coding | HeLa | -- | Aging | Accelerate | | L | 30591555 |
| Sen_G_0958 | STAT3 | 6774 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast | Lung | Idiopathic pulmonary fibrosis | Accelerate | | L | 30608861 |
| Sen_G_0959 | CLPP | 8192 | -- | -- | Unclear | -- | -- | protein coding | HepG2,HuH-7 | -- | Decompensated cirrhosis | Prevent | | L | 30878663 |
| Sen_G_0960 | ALOX15B | 247 | -- | -- | Unclear | -- | -- | protein coding | Pca | -- | Aging | Accelerate | | L | 15750631 |
| Sen_G_0961 | BCL6 | 604 | -- | -- | Unclear | P53 | Upregulation | protein coding | WI-38,MEF | -- | Aging | Accelerate | | L | 18524763 |
| Sen_G_0962 | TPP2 | 7174 | -- | -- | Unclear | -- | -- | protein coding | Fibroblast,PBMC | Skin | Evans syndrome | Prevent | | HL | 25414442 |
| Sen_G_0963 | TLR8 | 51311 | CAMP | Downregulation | Unclear | -- | -- | protein coding | MCF-7,M628,PC-3 | -- | Aging | Prevent | | L | 25231413 |
| Sen_G_0964 | TERT | 7015 | -- | -- | Unclear | P53 | -- | protein coding | HCT116 | -- | Colorectal cancer | Prevent | | HL | 23284306 |
| Sen_G_0965 | ETV1 | 2115 | P53 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Prevent | | HL | 23284306 |
| Sen_G_0966 | ATR | 545 | P53 | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Prevent | | HL | 23284306 |
| Sen_G_0967 | SKP2 | 6502 | JARID1B | Inhibition | Ubiquitylation | -- | -- | protein coding | PC-3 | -- | Prostate cancer | Prevent | | HL | 25596733 |
| Sen_G_0968 | TGFB1 | 7040 | MIR-29//H4K20ME3 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | MEF | Embryo | Aging | Accelerate | | L | 29967491 |
| Sen_G_0969 | MYSM1 | 114803 | -- | -- | Unclear | -- | -- | protein coding | C4-2,22Rv1 | -- | Prostate cancer | Accelerate | | HL | 31761786 |
| Sen_G_0970 | MYC | 4609 | WRN | Upregulation | Unclear | -- | -- | protein coding | AG00780,AG03141,Fibroblast | -- | Werner syndrome | Accelerate | | HL | 12842909 |
| Sen_G_0971 | WRN | 7486 | -- | -- | Unclear | -- | -- | protein coding | MEF | Embryo | Werner syndrome | Accelerate | | L | 16264192 |
| Sen_G_0972 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | BJ | -- | Aging | Prevent | | L | 16449970 |
| Sen_G_0973 | TWIST1 | 7291 | P14 | Downregulation | Unclear | -- | -- | protein coding | NPTX,HPr-1 | -- | Aging | Prevent | | L | 17690110 |
| Sen_G_0974 | BCL6 | 604 | P53 | Upregulation | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 18524763 |
| Sen_G_0975 | TERT | 7015 | -- | -- | Unclear | -- | -- | protein coding | RPTEC | Kidney | Aging | Prevent | | L | 18715936 |
| Sen_G_0976 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | ES | -- | Aging | Prevent | | HL | 19041753 |
| Sen_G_0977 | BRCA1 | 672 | -- | -- | Unclear | -- | -- | protein coding | MCF-7,HCC1937,HCC+BR,HBL-100 | -- | Aging | Prevent | | L | 19372557 |
| Sen_G_0978 | LIN9 | 286826 | P16//P21 | --//-- | Unclear | -- | -- | protein coding | BJ,MEF | Embryo | Aging | Prevent | | L | 21860417 |
| Sen_G_0979 | CTSL | 1514 | A-TYPE LAMINS//53BP1//NHEJ | --//Downregulation//-- | Unclear | -- | -- | protein coding | MEF | -- | Aging | Accelerate | | L | 21750527 |
| Sen_G_0980 | SIRT1 | 23411 | HISTONE 1(H1)//CONDENSIN I COMPLEX | --//-- | Unclear | -- | -- | protein coding | HCT116 | -- | Aging | Prevent | | L | 21636977 |
| Sen_G_0981 | MAD2L1 | 4085 | P21//P14 | --//-- | Unclear | P53-P21 | -- | protein coding | IMR-90 | -- | Aging | Prevent | | L | 22170163 |
| Sen_G_0982 | MLH1 | 4292 | -- | -- | Unclear | -- | -- | protein coding | CD34+ | -- | Aging | Prevent | | HL | 22740444 |
| Sen_G_0983 | SIRT6 | 51548 | PARP1//RAD51//RAD51C//RAD52//NBS1//SIRT6//CTIP | Activation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | Fibroblast,HCA2-HR | -- | Aging | Prevent | | L | 22753495 |
| Sen_G_0984 | ATM | 472 | CDC25A | Downregulation | Unclear | -- | -- | protein coding | HPr-1 | -- | Aging | Accelerate | | L | 23272087 |
| Sen_G_0985 | RTEL1 | 51750 | TRF1 | -- | Unclear | -- | -- | protein coding | Lymphoma cell line | Blood | Aging | Prevent | | HL | 23959892 |
| Sen_G_0986 | UHRF1 | 29128 | TP53//CDKN1A | Upregulation//Upregulation | Unclear | -- | -- | protein coding | Hepatocyte | Liver | Hepatocellular carcinoma | Accelerate | | HL | 24486181 |
| Sen_G_0987 | SUV39H1 | 6839 | P21 | -- | Unclear | -- | -- | protein coding | Fibroblast | -- | Aging | Prevent | | L | 25063769 |
| Sen_G_0988 | SPRTN | 83932 | -- | -- | Unclear | -- | -- | protein coding | LCL | -- | Hepatocellular carcinoma | Prevent | | HL | 25261934 |
| Sen_G_0989 | SDHD | 6392 | -- | -- | Unclear | -- | -- | protein coding | Sdh4 | -- | Paraganglioma | Prevent | | L | 25328978 |
| Sen_G_0990 | SSX2 | 6757 | -- | -- | Unclear | -- | -- | protein coding | MCF-7-TETSSX2,A375-TET-SSX2,HEK293-TET-SSX2(H293-TET-SSX2) | -- | Melanoma | Accelerate | | L | 25363656 |
| Sen_G_0991 | BRCA1 | 672 | SIRT1 | -- | Unclear | P53//PRB | --//-- | protein coding | HMEC | Mammary Gland | Aging | Accelerate | | HL | 26106036 |
| Sen_G_0992 | PML | 5371 | -- | -- | Unclear | -- | -- | protein coding | MRC-5,WI-38 | -- | Aging | Prevent | | L | 26119943 |
| Sen_G_0993 | CDH1 | 999 | -- | -- | Unclear | -- | -- | protein coding | Htertrpe | -- | Aging | Prevent | | L | 26939887 |
| Sen_G_0994 | SIRT6 | 51548 | H3K18AC | -- | Unclear | -- | -- | protein coding | U2OS | -- | Aging | Prevent | | HL | 27043296 |
| Sen_G_0995 | WSB1 | 26118 | ATM | Downregulation | Ubiquitylation | -- | -- | protein coding | MEF | Embryo | Aging | Prevent | | L | 27958289 |
| Sen_G_0996 | DUSP3 | 1845 | -- | -- | Unclear | -- | -- | protein coding | HeLa,MEWO | -- | Aging | Prevent | | L | 28389334 |
| Sen_G_0997 | PIM1 | 5292 | UHRF1 | Downregulation | Phosphorylation | -- | -- | protein coding | 2BS,IMR-90 | -- | Aging | Accelerate | | HL | 28394343 |
| Sen_G_0998 | SIRT7 | 51547 | SNF2H | Upregulation | Unclear | -- | -- | protein coding | WI-38,hTRT-WI38 | -- | Aging | Prevent | | L | 29728458 |
| Sen_G_0999 | TIMELESS | 8914 | E2F1 | -- | Binding to promoter | -- | -- | protein coding | 2BS | -- | Aging | Prevent | | HL | 30100061 |
| Sen_G_1000 | TET1 | 80312 | P53 | Inhibition | Binding to promoter | -- | -- | protein coding | H1299,H1975,H226 | Lung | Lung cancer | Prevent | | HL | 30622117 |
| Sen_G_1000 | TET1 | 80312 | P53 | Inhibition | Binding to promoter | -- | -- | protein coding | H1299,H1975,H226 | Lung | Lung cancer | Prevent | | HL | 30622117 |
| Sen_G_1001 | SETD1A | 9739 | SKP2 | -- | Methylation | -- | -- | protein coding | MDA-MB-231,MCF-7,MDA-MB-468,BT-549,HT1299,A549 | Mammary Gland,Lung | Aging | Prevent | | HL | 31253781 |
| Sen_G_1002 | TRPC7 | 57113 | -- | -- | Unclear | -- | -- | protein coding | Keratinocyte | Lung | Aging | Accelerate | | HL | 31755176 |
| Sen_G_1003 | AGT | 183 | -- | -- | Unclear | P53-P21 | Upregulation | protein coding | VSMC | Aorta | Atherosclerosis | Accelerate | Others | L | 16908765 |
| Sen_G_1004 | AR | 367 | P16 | Upregulation | Unclear | -- | -- | protein coding | DPC | Skin | Androgenetic alopecia | Accelerate | Others | L | 24244503 |
| Sen_G_1005 | ARPC1B | 10095 | -- | -- | Unclear | -- | -- | protein coding | Saos-2,HDF | -- | Aging | Accelerate | Others | L | 21628992 |
| Sen_G_1000 | TET1 | 80312 | P53 | -- | Binding to promoter | -- | -- | protein coding | H1299,H1975,H226 | Lung | Lung cancer | Prevent | | HL | 30622117 |
| Sen_G_1007 | BCL6 | 604 | CYCLIN D1 | Upregulation | Unclear | -- | -- | protein coding | MEF | -- | Aging | Prevent | Others | L | 11914273 |
| Sen_G_1008 | BMI1 | 648 | P16 | Downregulation | Unclear | PRB | -- | protein coding | WI-38 | -- | Aging | Prevent | Others | L | 12482990 |
| Sen_G_1009 | BRAF | 673 | P16 | Upregulation | Unclear | -- | -- | protein coding | Melanocyte | Skin,Foreskin | Aging | Accelerate | Others | L | 16079850 |
| Sen_G_1010 | CAV1 | 857 | FAK//RAC1//CDC42 | --//Activation//Activation | Unclear | -- | -- | protein coding | Fibroblast | Foreskin | Aging | Prevent | Others | L | 15263006 |
| Sen_G_1011 | CBX8 | 57332 | BMI1//INK4A//ARF | --//Downregulation//Downregulation | Unclear | -- | -- | protein coding | MEF,Fibroblast | -- | Aging | Prevent | Others | HL | 17332741 |
| Sen_G_1012 | IL1A | 3552 | -- | -- | Unclear | -- | -- | protein coding | endothelial cell | -- | Aging | Prevent | Others | L | 2218499 |
| Sen_G_1013 | TGFB1I1 | 7041 | -- | -- | Unclear | -- | -- | protein coding | KMST-6,SUSM1 | -- | Aging | Accelerate | Others | L | 9032249 |
| Sen_G_1014 | HRAS | 3265 | -- | -- | Unclear | P53//P16-RB | --//-- | protein coding | IMR-90 | -- | Aging | Accelerate | Others | L | 9054499 |
| Sen_G_1015 | VEGFA | 7422 | P21//P16//P27 | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | HDMEC | Foreskin | Aging | Prevent | Others | L | 9160882 |
| Sen_G_1016 | CDKN1A | 1026 | -- | -- | Unclear | -- | -- | protein coding | LF1 | -- | Aging | Accelerate | Others | L | 9242615 |
| Sen_G_1017 | TP53 | 7157 | -- | -- | Unclear | -- | -- | protein coding | EJ | -- | Tumor | Accelerate | Others | L | 9275177 |
| Sen_G_1018 | CDKN2A | 1029 | PRB | -- | Unclear | -- | -- | protein coding | TIG-3 | -- | Aging | Accelerate | Others | L | 9607312 |
| Sen_G_1019 | RAF1 | 5894 | P16 | Upregulation | Unclear | MEK-MAPK | Activation | protein coding | IMR-90 | -- | Aging | Accelerate | Others | L | 9765202 |
| Sen_G_1020 | MORF4 | 10934 | -- | -- | Unclear | -- | -- | protein coding | A9+F4 | -- | Aging | Accelerate | Others | HL | 9891081 |
| Sen_G_1021 | E2F1 | 1869 | P14//P53 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | WI-38,NIH-3T3 | -- | Aging | Accelerate | Others | L | 10594030 |
| Sen_G_1022 | CDKN2B | 1030 | -- | -- | Unclear | RB | -- | protein coding | U-251 MG,Tp483 MG,U373 MG,SW1783 | -- | Aging | Accelerate | Others | L | 10939591 |
| Sen_G_1023 | ETS1 | 2113 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Accelerate | Others | L | 11234019 |
| Sen_G_1024 | ID1 | 3397 | -- | -- | Unclear | RB | Downregulation | protein coding | HDMEC | -- | Aging | Prevent | Others | L | 12177246 |
| Sen_G_1025 | MAP2K6 | 5608 | P21 | Upregulation | Unclear | P38 | Activation | protein coding | U2OS | -- | Aging | Accelerate | Others | HL | 12208764 |
| Sen_G_1026 | PNPT1 | 87178 | C-MYC | Downregulation | Unclear | -- | -- | protein coding | HO-1,melanoma cell,WM278,MEWO | -- | Aging | Accelerate | Others | L | 12721301 |
| Sen_G_1027 | MXD4 | 10608 | MAX//C-MYC | --//Downregulation | Unclear | -- | -- | protein coding | 293,HeLa | -- | Aging | Accelerate | Others | HL | 12761891 |
| Sen_G_1028 | SOD1 | 6647 | P53 | -- | Unclear | -- | -- | protein coding | WI-38,WI38-SV40 | -- | Aging | Prevent | Others | L | 12871978 |
| Sen_G_1029 | MAP2K1 | 5604 | -- | -- | Unclear | MEK-ERK | -- | protein coding | HIEC,IEC-6 | Small intestine | Aging | Accelerate | Others | L | 14701721 |
| Sen_G_1030 | NINJ1 | 4814 | P21//CYCLIN A//CDK2//CDK4//CDK6 | Upregulation//Downregulation//Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | HuH-7 | HCC tissue,Liver | Hepatocellular carcinoma | Accelerate | Others | L | 15464245 |
| Sen_G_1031 | SMURF2 | 64750 | -- | -- | Unclear | P53//RB | --//-- | protein coding | BJ,WS1,WI-38 | Foreskin,Skin,Lung,Mammary Gland | Aging | Accelerate | Others | HL | 15574587 |
| Sen_G_1032 | DHCR24 | 1718 | P53//MDM2 | Inhibition//-- | Unclear | RAS | Upregulation | protein coding | REF,WI-38 | -- | Aging | Accelerate | Others | HL | 15577914 |
| Sen_G_1033 | LEO1 | 12319 | -- | -- | Unclear | P16//P21//PTEN | Upregulation//Upregulation//Upregulation | protein coding | 2BS | -- | Aging | Accelerate | Others | HL | 15791002 |
| Sen_G_1034 | ING2 | 3622 | P53//P300 | --//-- | Unclear | -- | -- | protein coding | MRC-5 | -- | Aging | Accelerate | Others | L | 16024799 |
| Sen_G_1035 | PRPF19 | 27339 | -- | -- | Unclear | -- | -- | protein coding | HUVEC,I38-neo-1 ,I38-SNEV-1 | -- | Aging | Prevent | Others | L | 16388800 |
| Sen_G_1036 | CSNK2A1 | 1457 | P53//P21 | Activation//Activation | Unclear | -- | -- | protein coding | IMR-90 | Liver and Testis | Aging | Prevent | Others | L | 16442104 |
| Sen_G_1037 | IRF3 | 3661 | P53 | Activation | Unclear | -- | -- | protein coding | BJ,IMR-90 | -- | Aging | Accelerate | Others | L | 16513254 |
| Sen_G_1038 | MYC | 4609 | BMI-1//P16 | --//-- | Unclear | -- | -- | protein coding | BJ,IMR-90 | -- | Aging | Prevent | Others | L | 16537449 |
| Sen_G_1039 | PIAS4 | 51588 | E6 | -- | Unclear | P53-P21//RB-P16 | Activation//Activation | protein coding | WI-38 | -- | Aging | Accelerate | Others | L | 16793547 |
| Sen_G_1040 | KL | 9365 | -- | -- | Unclear | INSULIN-IGF-1//P53-P21 | --//Downregulation | protein coding | MRC-5 | -- | Aging | Prevent | Others | L | 17014852 |
| Sen_G_1041 | CXCL1 | 2919 | -- | -- | Unclear | P53 | -- | protein coding | NOF150,NOF151 | -- | Ovarian cancer | Accelerate | Others | L | 17060621 |
| Sen_G_1042 | RNASEL | 6041 | -- | -- | Unclear | -- | -- | protein coding | MEF,WI-38,HDF,SV-WI38,Swiss 3T3,NIH-3T3 | -- | Aging | Accelerate | Others | L | 17130839 |
| Sen_G_1043 | PCGF2 | 7703 | BMI-1//C-MYC | Downregulation//Downregulation | Unclear | -- | -- | protein coding | MRC-5 | -- | Aging | Accelerate | Others | L | 17151361 |
| Sen_G_1044 | MAPKAPK5 | 8550 | -- | -- | Phosphorylation | RAS//P38//P53-P21 | --//--//Activation | protein coding | MEF | Skin | Aging | Accelerate | Others | L | 17254968 |
| Sen_G_1045 | PEX19 | 5824 | -- | -- | Methylation | P16 | Upregulation | protein coding | U2OS,Human immortalized postcrisis cell,Fibroblast | Human tumor tissue and normal tissue | Tumor | Accelerate | Others | L | 17389721 |
| Sen_G_1046 | HSPA9 | 3313 | -- | -- | Methylation | P53-P21 | Activation | protein coding | U2OS,Human immortalized postcrisis cell,Fibroblast | Human tumor tissue and normal tissue | Tumor | Accelerate | Others | L | 17389721 |
| Sen_G_1047 | MMP9 | 4318 | P21CIP//P16 | --//Upregulation | Unclear | ERK-MAPK | -- | protein coding | Daoy medulloblastoma cell line | Tumor tissue,Brain | Medulloblastoma | Accelerate | Others | L | 17510426 |
| Sen_G_1048 | EHF | 26298 | P16 | Upregulation | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | Others | HL | 17627613 |
| Sen_G_1049 | WNT2 | 7472 | -- | -- | Unclear | -- | -- | protein coding | RPE,WI-38 | -- | Aging | Prevent | Others | L | 17643369 |
| Sen_G_1050 | ITGB4 | 3691 | PC-PLC//P53 | Downregulation//Upregulation | Unclear | -- | -- | protein coding | HUVEC | -- | Aging | Accelerate | Others | L | 17964297 |
| Sen_G_1051 | HSPB2 | 3316 | -- | -- | Unclear | P53-P21 | Downregulation | protein coding | MCF 10A | -- | Aging | Prevent | Others | L | 18089808 |
| Sen_G_1052 | SPIN1 | 10927 | -- | -- | Unclear | -- | -- | protein coding | HeLa | -- | Aging | Accelerate | Others | HL | 18201843 |
| Sen_G_1053 | ID1 | 3397 | CDK2//CDK4//P16 | --//--//Inhibition | Unclear | -- | -- | protein coding | MEF | Embryo | Aging | Prevent | Others | L | 11427735 |
| Sen_G_1054 | NANOG | 79923 | P16//P21//P53//PBX1 | Downregulation//Downregulation//Downregulation//Upregulation | Unclear | AKT | Activation | protein coding | HF-MSC | Hair follicle | Aging | Prevent | Others | L | 31885790 |
| Sen_G_1055 | TXNIP | 10628 | -- | -- | Unclear | AKT | Downregulation | protein coding | MEF | Kidney | Aging | Prevent | Others | L | 30168649 |
| Sen_G_1056 | AKT1 | 207 | ROS//FOXO//SESTRIN 3 | Upregulation//Downregulation//-- | Unclear | -- | -- | protein coding | MEF | Embryo | Aging | Accelerate | Others | L | 19061837 |
| Sen_G_1057 | EPHA3 | 2042 | -- | -- | Unclear | P16//P53 | --//-- | protein coding | hTERT-RPE1 | -- | Aging | Prevent | Others | HL | 23324396 |
| Sen_G_1058 | MAP2K2 | 5605 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | Others | L | 9765203 |
| Sen_G_1059 | MAPK14 | 1432 | -- | -- | Unclear | -- | -- | protein coding | WI-38,MRC-5 | -- | Aging | Accelerate | Others | L | 12581156 |
| Sen_G_1060 | CDK4 | 1019 | -- | -- | Unclear | P53 | Upregulation | protein coding | HDF | -- | Aging | Prevent | Others | L | 12082615 |
| Sen_G_1061 | CDK6 | 1021 | -- | -- | Unclear | P53 | Upregulation | protein coding | HDF | -- | Aging | Prevent | Others | L | 12082615 |
| Sen_G_1062 | EWSR1 | 2130 | -- | -- | Unclear | -- | -- | protein coding | Lin-Sca1+c-Kit+,BM,HSPC | Blood | Ewing sarcoma | Prevent | Others | L | 21030557 |
| Sen_G_1063 | MAP3K7 | 6885 | -- | -- | Unclear | NF-κB | Activation | protein coding | IMR-90,MRC-5,GP293 | -- | Aging | Accelerate | Others | HL | 26583757 |
| Sen_G_1064 | PRKCD | 5580 | -- | -- | Unclear | NF-κB | Activation | protein coding | IMR-90,MRC-5,GP293 | -- | Aging | Accelerate | Others | HL | 26583757 |
| Sen_G_1065 | MATK | 4145 | -- | -- | Unclear | NF-κB | Activation | protein coding | IMR-90,MRC-5,GP293 | -- | Aging | Accelerate | Others | HL | 26583757 |
| Sen_G_1066 | FOXM1 | 2305 | -- | -- | Unclear | -- | -- | protein coding | GBC-SD | -- | Gallbladder cancer | Prevent | Others | L | 25071344 |
| Sen_G_1067 | IGFBP3 | 3486 | TGF-β1 | -- | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | Others | HL | 18329388 |
| Sen_G_1068 | RSL1D1 | 26156 | -- | -- | Unclear | PTEN-P27 | Downregulation | protein coding | HEK293,2BS | -- | Aging | Prevent | Others | HL | 18678645 |
| Sen_G_1069 | MBP1 | 841633 | -- | -- | Acetylation Phosphorylation | P53-P21 | -- | protein coding | HFF | -- | Aging | Prevent | Others | HL | 18852884 |
| Sen_G_1070 | IFNG | 3458 | -- | -- | Unclear | P53 | -- | protein coding | HUVEC,MEF | -- | Atherosclerosis | Accelerate | Others | L | 19071156 |
| Sen_G_1071 | CPEB1 | 64506 | P53 | -- | Unclear | -- | -- | protein coding | HFF,WI-38 | -- | Aging | Prevent | Others | L | 19141477 |
| Sen_G_1072 | PLA2R1 | 22925 | -- | -- | Unclear | P53 | Activation | protein coding | HDF | -- | Aging | Accelerate | Others | HL | 19197340 |
| Sen_G_1073 | SUPT5H | 6829 | -- | -- | Unclear | P53 | -- | protein coding | HeLa | -- | Aging | Prevent | Others | HL | 19210550 |
| Sen_G_1074 | PRKCA | 5578 | HTERT | Downregulation | Unclear | -- | -- | protein coding | TIG-1,Human normal diploid cell | -- | Aging | Accelerate | Others | L | 19279193 |
| Sen_G_1075 | TOP1 | 7150 | -- | -- | Unclear | P53 | Activation | protein coding | WI-38,IMR-90,U2OS,HDF | -- | Aging | Accelerate | Others | HL | 19435923 |
| Sen_G_1076 | RUNX1 | 861 | P53//P38MAPK | --//Activation | Unclear | -- | -- | protein coding | Hs68 | -- | Aging | Accelerate | Others | L | 19448675 |
| Sen_G_1077 | PPM1D | 8493 | P16//P38 | Downregulation//Downregulation | Unclear | -- | -- | protein coding | mesenchymal-stem-cell | -- | Aging | Prevent | Others | L | 19544416 |
| Sen_G_1078 | RPS6KA6 | 27330 | -- | -- | Unclear | -- | -- | protein coding | HCT116,IMR-90 | Colon | Colorectal cancer | Accelerate | Others | L | 19584160 |
| Sen_G_1079 | SIN3B | 23309 | E2F | -- | Unclear | P19-P53 | -- | protein coding | MEF | -- | Aging | Accelerate | Others | L | 19654306 |
| Sen_G_1080 | PSMD14 | 10213 | CDK1//CYCLIN B//CDC25C | Downregulation//Downregulation//Downregulation | Phosphorylation | -- | -- | protein coding | H1299,HeLa,hTERT-HMEC1 | -- | Aging | Prevent | Others | HL | 19732767 |
| Sen_G_1081 | MECP2 | 4204 | -- | -- | Unclear | -- | -- | protein coding | mononuclear cell | Bone | Aging | Prevent | Others | L | 20065105 |
| Sen_G_1082 | NFE2L2 | 4780 | 18αGA | -- | Unclear | -- | -- | protein coding | HFL-1 | -- | Aging | Prevent | Others | L | 20068043 |
| Sen_G_1083 | TRX1 | 824267 | -- | -- | Unclear | P53//P16 | -- | protein coding | BJ | -- | Aging | Prevent | Others | L | 20074557 |
| Sen_G_1084 | CENPA | 1058 | -- | -- | Unclear | P53 | -- | protein coding | TIG-3,HeLa | -- | Aging | Prevent | Others | L | 20160010 |
| Sen_G_1085 | ENDOG | 2021 | -- | -- | Unclear | -- | -- | protein coding | HUVEC | Umbilical vein | Aging | Prevent | Others | L | 20211237 |
| Sen_G_1086 | DDB2 | 1643 | -- | -- | Unclear | -- | -- | protein coding | MEF | Embryo | Aging | Accelerate | Others | L | 20351176 |
| Sen_G_1087 | SNAIL | 778762 | -- | -- | Unclear | -- | -- | protein coding | LNCaP,PC-3 | -- | Prostate cancer | Prevent | Others | L | 20397042 |
| Sen_G_1088 | PTTG1 | 9232 | P53 | Upregulation | Unclear | -- | -- | protein coding | IMR-90,BJ-1,WI-38 | -- | Aging | Accelerate | Others | L | 20452981 |
| Sen_G_1089 | TXNIP | 10628 | FOXO3A//MIR-17-5P | Upregulation//Downregulation | Binding to promoter | -- | -- | protein coding | 2BS | -- | Aging | Accelerate | Others | L | 20656682 |
| Sen_G_1090 | TNFSF15 | 9966 | -- | -- | Unclear | -- | -- | protein coding | CEP | Peripheral blood | Aging | Accelerate | Others | HL | 20675618 |
| Sen_G_1091 | BRG1 | 834543 | -- | -- | Unclear | RB-P53 | -- | protein coding | MSC | Bone marrow | Aging | Prevent | Others | L | 20697355 |
| Sen_G_1092 | CHK1 | 852577 | -- | -- | Unclear | -- | -- | protein coding | HCT116 | -- | Colorectal cancer | Accelerate | Others | L | 20716119 |
| Sen_G_1093 | NEK6 | 10783 | -- | -- | Unclear | -- | -- | protein coding | IMR-90,EJ | -- | Aging | Prevent | Others | L | 21099361 |
| Sen_G_1094 | VENTX | 27287 | -- | -- | Unclear | P53-P21//P16-RB | Activation//Activation | protein coding | 293,IMR-90 | -- | Aging | Accelerate | Others | L | 21325273 |
| Sen_G_1095 | YPEL3 | 83719 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | Mammary Gland | Breast cancer | Accelerate | Others | L | 21671470 |
| Sen_G_1096 | IGFBP6 | 3489 | -- | -- | Unclear | -- | -- | protein coding | HDF | -- | Aging | Prevent | Others | L | 21820463 |
| Sen_G_1097 | RUVBL2 | 10856 | -- | -- | Unclear | -- | -- | protein coding | A498,KRC/Y | The tumor specimens and corresponding tumor adjacent renal tissue | Renal carcinoma | Prevent | Others | L | 22341977 |
| Sen_G_1098 | IGFBP7 | 3490 | P21 | Upregulation | Phosphorylation | -- | -- | protein coding | MCF-7 | -- | Breast cancer | Accelerate | Others | L | 22392074 |
| Sen_G_1099 | MCL1 | 4170 | P53 | -- | Unclear | -- | -- | protein coding | HCT116,MCF 10A,MCF-7,MEL526,MEF | Tumor tissue | Cancer | Prevent | Others | HL | 22451485 |
| Sen_G_1100 | TRPM8 | 79054 | -- | -- | Unclear | -- | -- | protein coding | BxPC-3,PANC-1 | Pancreas/duct | Pancreatic cancer | Prevent | Others | L | 22555807 |
| Sen_G_1101 | POU5F1 | 5460 | -- | -- | Unclear | -- | -- | protein coding | MSC | -- | Aging | Accelerate | Others | HL | 22746537 |
| Sen_G_1102 | NEK4 | 6787 | -- | -- | Unclear | -- | -- | protein coding | HFF,BJ,293T,IMR-90,WI-38 | Foreskin | Aging | Accelerate | Others | HL | 22851694 |
| Sen_G_1103 | ZMAT3 | 64393 | P21 | Downregulation | Unclear | -- | -- | protein coding | MCF-7 | Lung | Aging | Prevent | Others | L | 23085987 |
| Sen_G_1104 | PROX1 | 5629 | P53 | Upregulation | Unclear | -- | -- | protein coding | HepG2,Hep3B,Mahlavu,SK-HEP-1 | Tumor tissue | Hepatocellular carcinoma | Accelerate | Others | HL | 23291986 |
| Sen_G_1105 | SOX2 | 6657 | ATG10 | Upregulation | Unclear | -- | -- | protein coding | HCT116 | Tumor tissue | Colorectal cancer | Accelerate | Others | HL | 23451179 |
| Sen_G_1106 | YAP1 | 10413 | CDK6 | -- | Unclear | TEAD//RB-P53-P16 | --//-- | protein coding | IMR-90 | -- | Aging | Prevent | Others | L | 23576552 |
| Sen_G_1107 | NOTCH3 | 4854 | P21 | Upregulation | Unclear | -- | -- | protein coding | BJ | -- | Aging | Accelerate | Others | HL | 23610446 |
| Sen_G_1108 | PEBP1 | 5037 | -- | -- | Unclear | RAS-RAF-ERK | Downregulation | protein coding | hTERT-immortalized p21?/?,LF1,PC-3,HCT116 | -- | Aging | Accelerate | Others | L | 23814485 |
| Sen_G_1109 | DPY30 | 84661 | ID | -- | Unclear | -- | -- | protein coding | IMR-90,NT2 | -- | Aging | Prevent | Others | HL | 23872946 |
| Sen_G_1110 | ID4 | 3400 | E2F1 | Downregulation | Unclear | -- | -- | protein coding | DU 145 | -- | Prostate cancer | Accelerate | Others | L | 24122992 |
| Sen_G_1111 | RB1 | 5925 | -- | -- | Unclear | -- | -- | protein coding | Primary human bone cell | Bone | Retinoblastoma | Accelerate | Others | HL | 24231354 |
| Sen_G_1112 | HSPA5 | 3309 | P53//CDC2 | --//-- | Unclear | -- | -- | protein coding | A2780 | Bone | Ovarian cancer | Prevent | Others | L | 24756776 |
| Sen_G_1113 | ERRFI1 | 54206 | -- | -- | Phosphorylation | ERK//AKT | Activation//Activation | protein coding | WI-38 | -- | Retinoblastoma | Accelerate | Others | L | 24815188 |
| Sen_G_1114 | LGALS3 | 404021 | P27 | -- | Unclear | -- | -- | protein coding | AGS,MEF | Stomach | Retinoblastoma | Prevent | Others | HL | 24971481 |
| Sen_G_1115 | DHX9 | 1660 | -- | -- | Unclear | P53 | -- | protein coding | MRC-5 | -- | Aging | Prevent | Others | HL | 24990949 |
| Sen_G_1116 | HMGB1 | 3146 | P21 | -- | Unclear | SP1 | -- | protein coding | A375,G361 | Melanoma | Melanoma | Prevent | Others | HL | 25051367 |
| Sen_G_1117 | SELENOH | 280636 | -- | -- | Unclear | ATM-P53 | -- | protein coding | MRC-5 | -- | Aging | Prevent | Others | L | 25336634 |
| Sen_G_1118 | PRKCH | 5583 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Aging | Accelerate | Others | L | 25412309 |
| Sen_G_1119 | PDCD10 | 11235 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Accelerate | Others | HL | 25655101 |
| Sen_G_1120 | P3H1 | 64175 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | Others | L | 26206181 |
| Sen_G_1121 | LIMA1 | 51474 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | Others | L | 26206181 |
| Sen_G_1122 | MAGOHA | 4116 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | Others | L | 26206181 |
| Sen_G_1123 | MAGOHB | 55110 | -- | -- | Unclear | -- | -- | protein coding | IMR-90 | -- | Aging | Prevent | Others | L | 26206181 |
| Sen_G_1124 | DUSP16 | 80824 | -- | -- | Unclear | P53//RB | --//-- | protein coding | PLC-PRF-5 | Human HCC sample,Tumor tissue | Aging | Prevent | Others | HL | 26381291 |
| Sen_G_1125 | GATA4 | 2626 | TRAF3IP2//IL1A | --//-- | Unclear | NF-κB | Activation | protein coding | IMR-90,BJ | Brain | Aging | Accelerate | Others | HL | 26404840 |
| Sen_G_1126 | NANOG | 79923 | P27 | Downregulation | Unclear | -- | -- | protein coding | NIH-3T3 MEF,Mouse Fibroblast cell | -- | Aging | Prevent | Others | L | 26795560 |
| Sen_G_1127 | HRAS | 3265 | -- | -- | Unclear | -- | -- | protein coding | MEF | Embryo | Lung cancer | Accelerate | | L | 19421407 |
| Sen_G_1128 | TFDP1 | 7027 | -- | -- | Unclear | -- | -- | protein coding | TIG-3 | -- | Aging | Prevent | | L | 15716376 |
| Sen_G_1129 | MIR200A | 406983 | OGG1-2A//NRLP3//IL-1β//BMI-1//P16 | Downregulation//Upregulation//Upregulation//Downregulation//Upregulation | Unclear | -- | -- | ncRNA | Keratinocyte | -- | Aging | Accelerate | | HL | 29765508 |
| Sen_G_1130 | LINC00673 | 100499467 | -- | -- | Unclear | P53 | -- | ncRNA | A549,IMR-90 | -- | Lung cancer | Prevent | | HL | 30499379 |
| Sen_G_1131 | CIRCLARP4 | -- | -- | -- | Unclear | MIR-761-RUNX3-P53-P21 | -- | ncRNA | MHCC97L,HCCLM3 | -- | Hepatocellular carcinoma | Accelerate | | HL | 30520539 |
| Sen_G_1132 | MIR181A1 | 406995 | AKT3//CCND2 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | ULM,MM | -- | Uterine leiomyomas | Accelerate | | HL | 30097674 |
| Sen_G_1133 | MIR182 | 406958 | AKT3//CCND2 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | ULM,MM | -- | Uterine leiomyomas | Accelerate | | HL | 30097674 |
| Sen_G_1134 | MIR26B | 407017 | P16 | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 24217920 |
| Sen_G_1135 | MIR181A1 | 406995 | P16 | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 24217920 |
| Sen_G_1136 | MIR210 | 406992 | P16 | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 24217920 |
| Sen_G_1137 | MIR424 | 494336 | P16 | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 24217920 |
| Sen_G_1138 | MIR194-1 | 406969 | DNMT3A | Downregulation | Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 27981676 |
| Sen_G_1139 | MIR22 | 407004 | SIRT1//SP1//CDK6 | --// --// -- | Unclear | -- | -- | ncRNA | MRC-5,Fibroblast | -- | Breast cancer | Accelerate | | HL | 21502362 |
| Sen_G_1140 | MIR24-1 | 407012 | TOP1 | Downregulation | Unclear | -- | -- | ncRNA | HDF | -- | Aging | Accelerate | | L | 26748253 |
| Sen_G_1141 | TERC | 7012 | -- | -- | Unclear | -- | -- | ncRNA | 2BS | -- | Aging | Accelerate | | HL | 30788732 |
| Sen_G_1142 | MIR34A | 407040 | C-MYC//FOXM1//P53 | Upregulation//Upregulation//-- | Unclear | FOXM1-C-MYC | -- | ncRNA | HepG2,SMMC-7721,HHCC,SK-Hep-1 | -- | Hepatocellular carcinoma | Accelerate | | L | 25686834 |
| Sen_G_1143 | MIR433 | 574034 | CDK6 | Downregulation | Unclear | -- | -- | ncRNA | A2780 | -- | Ovarian cancer | Accelerate | | L | 25684390 |
| Sen_G_1144 | MIR186 | 406962 | CKII//P53//P21/WAF1 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 23137536 |
| Sen_G_1145 | MIR216B | 100126319 | CKII//P53//P21/WAF1 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 23137536 |
| Sen_G_1146 | MIR337 | 442905 | CKII//P53//P21/WAF1 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 23137536 |
| Sen_G_1147 | MIR760 | 100126348 | CKII//P53//P21/WAF1 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Colorectal cancer | Accelerate | | HL | 23137536 |
| Sen_G_1148 | HOTAIR | 100124700 | -- | -- | Unclear | NF-κB//CHK1-P53-P21 | --//-- | ncRNA | A2780_CR5 | -- | Ovarian cancer | Accelerate | | HL | 27041570 |
| Sen_G_1149 | MIR145 | 406937 | SYNDECAN-1 | Downregulation | Unclear | -- | -- | ncRNA | T24 | -- | Urothelial carcinoma | Accelerate | | L | 26514209 |
| Sen_G_1150 | MIR23A | 407010 | -- | -- | Unclear | BCR-ABL-PI3K-AKT-MMP9 | -- | ncRNA | K562 | -- | Chronic myeloid leukemia | Accelerate | | HL | 25213664 |
| Sen_G_1151 | MIR221 | 407006 | -- | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 28658612 |
| Sen_G_1152 | MIR222 | 407007 | -- | -- | Unclear | -- | -- | ncRNA | Fibroblast | -- | Aging | Accelerate | | HL | 28658612 |
| Sen_G_1153 | H19 | 283120 | MIR-22 | Downregulation | Unclear | WNT-β-CATENIN | -- | ncRNA | NPC | -- | Disc degenerative disease | Accelerate | | L | 29520849 |
| Sen_G_1154 | MIR107 | 406901 | P16NK4A//PTEN | Upregulation//Downregulation | Phosphorylation Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | HL | 29857052 |
| Sen_G_1155 | RP11-670E13.6 | -- | -- | -- | Unclear | P16-PRB | -- | ncRNA | HDF | -- | Aging | Prevent | | HL | 29143326 |
| Sen_G_1156 | MIR138-1 | 406929 | E2H2 | Downregulation | Unclear | -- | -- | ncRNA | SN-12 | -- | Renal carcinoma | Accelerate | | HL | 24406044 |
| Sen_G_1157 | MIR22 | 407004 | AKT3 | Downregulation | Unclear | -- | -- | ncRNA | EPC | -- | Aging | Accelerate | | L | 25323119 |
| Sen_G_1158 | MIR181A1 | 406995 | SIRT1 | Downregulation | Unclear | -- | -- | ncRNA | CD4+T | -- | HCV infection | Accelerate | | L | 27354409 |
| Sen_G_1159 | MIR503 | 574506 | P16 | Downregulation | Unclear | -- | -- | ncRNA | HPNE | -- | Pancreatic cancer | Prevent | | L | 28942143 |
| Sen_G_1160 | MIR146A | 406938 | -- | -- | Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Prevent | | L | 21511256 |
| Sen_G_1161 | MIR10A | 406902 | KLF4 | Downregulation | Unclear | -- | -- | ncRNA | MSC | -- | Aging | Prevent | | HL | 23696417 |
| Sen_G_1162 | MIR34A | 407040 | SIRT1 | Downregulation | Unclear | -- | -- | ncRNA | HASMC | -- | Cardiovascular disease | Accelerate | | L | 25352462 |
| Sen_G_1163 | MIR152 | 406943 | SIRT7 | Downregulation | Unclear | -- | -- | ncRNA | HDPSC | -- | Aging | Accelerate | | L | 26991832 |
| Sen_G_1164 | MIR21 | 406991 | SPRY1 | Downregulation | Unclear | PTEN-PI3K-AKT | -- | ncRNA | U87 | -- | Glioma | Prevent | | L | 29316313 |
| Sen_G_1165 | MIR449A | 554213 | E2F3 | Downregulation | Unclear | -- | -- | ncRNA | 95D,A549 | -- | Lung cancer | Accelerate | | L | 24211326 |
| Sen_G_1166 | MIR340 | 442908 | PLAT | Downregulation | Unclear | -- | -- | ncRNA | GIC | -- | Glioma | Accelerate | | L | 25627976 |
| Sen_G_1167 | MIR34A | 407040 | MAP2K1//AXL//FUT1//AREG | --//--//--//-- | Unclear | -- | -- | ncRNA | UM-SCC-23,Fadu | -- | Squamous cell carcinoma | Accelerate | | HL | 28485160 |
| Sen_G_1168 | MIR125B1 | 406911 | HMGA2 | Downregulation | Unclear | -- | -- | ncRNA | KYSE150,KYSE510 | -- | Esophageal cancer | Accelerate | | HL | 28968424 |
| Sen_G_1169 | MIR34A | 407040 | -- | -- | Unclear | -- | -- | ncRNA | PPC-1 | -- | Prostate cancer | Accelerate | | L | 22719071 |
| Sen_G_1170 | MIR212 | 406994 | SIRT1 | Downregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Prostate cancer | Accelerate | | L | 26439987 |
| Sen_G_1171 | MIR23A | 407010 | HAS2 | Downregulation | Unclear | -- | -- | ncRNA | HDF | -- | Aging | Accelerate | | HL | 25264594 |
| Sen_G_1172 | MIR141 | 406933 | ZMPSTE24 | Downregulation | Unclear | -- | -- | ncRNA | MSC | Umbilical cord blood | Aging | Accelerate | | L | 24101728 |
| Sen_G_1173 | MIR17 | 406952 | PAR4 | Downregulation | Unclear | CEBPB-FAK | -- | ncRNA | MCF | Heart | Aging | Prevent | | L | 25472717 |
| Sen_G_1174 | MIR143 | 406935 | -- | -- | Unclear | -- | -- | ncRNA | VSMC | -- | Aging | Accelerate | | L | 25655189 |
| Sen_G_1175 | MIR449A | 554213 | CYCLIN D1//HDAC1 | Downregulation//Downregulation | Unclear | RB | Downregulation | ncRNA | B5,PC-3,DU 145,DU-1.1 | -- | Prostate cancer | Accelerate | | L | 20948989 |
| Sen_G_1176 | MIR21 | 406991 | CDC25A//NF1B | --//-- | Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | HL | 23496142 |
| Sen_G_1177 | MIAT | 440823 | -- | -- | Unclear | -- | -- | ncRNA | MCF-7 | -- | Breast cancer | Prevent | | L | 29345338 |
| Sen_G_1178 | OVAAL | 148756 | STK3//P27 | --//-- | Unclear | RAF-MEK-ERK | Activation | ncRNA | ME4405,HCT116 | -- | Colorectal cancer | Prevent | | L | 30478051 |
| Sen_G_1179 | MIR34A | 407040 | B-RAFONCOGENE//ELK1//MYC | --//--//Downregulation | Unclear | -- | -- | ncRNA | TIG3 TERT/B-RAF:ER | -- | Aging | Accelerate | | HL | 19696787 |
| Sen_G_1180 | MIR137 | 406928 | KDM4A | Downregulation | Unclear | ARF-P53//P16-PRB | Activation//Activation | ncRNA | IMR-90 | -- | Pancreatic cancer | Accelerate | | L | 26904954 |
| Sen_G_1181 | MIR494 | 574452 | MRN | Downregulation | Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 29795397 |
| Sen_G_1182 | MIR221 | 407006 | -- | -- | Unclear | PTEN-AKT | -- | ncRNA | A549 | -- | Lung cancer | Accelerate | | L | 29876362 |
| Sen_G_1183 | TERC | 7012 | -- | -- | Unclear | -- | -- | ncRNA | -- | Lung | Inflammation | Prevent | | L | 26518879 |
| Sen_G_1184 | MIR29C | 407026 | CNOT6 | -- | Unclear | P53-P21//P16-PRB | Upregulation//Upregulation | ncRNA | MSC | -- | Aging | Accelerate | | L | 26792405 |
| Sen_G_1185 | MIR1236 | 100302242 | P21 | Upregulation | Unclear | CCND1-CDK4//CCND1-CDK6 | Downregulation | ncRNA | A549 | -- | Lung cancer | Accelerate | | L | 28631573 |
| Sen_G_1186 | MIR370 | 442915 | P21 | Upregulation | Unclear | CCND1-CDK4//CCND1-CDK6 | Downregulation | ncRNA | A549 | -- | Lung cancer | Accelerate | | L | 28631573 |
| Sen_G_1187 | MIR21 | 406991 | DRP1 | Downregulation | Unclear | AMPK-P53//AMPK-P16 | Activation | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 28347692 |
| Sen_G_1188 | MIR203A | 406986 | DRP1 | Downregulation | Unclear | AMPK-P53//AMPK-P16 | Activation | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 28347692 |
| Sen_G_1189 | H19 | 283120 | -- | -- | Phosphorylation | STAT3 | Downregulation | ncRNA | HUVEC | -- | Cardiovascular disease | Prevent | | HL | 30107531 |
| Sen_G_1190 | MALAT1 | 378938 | -- | -- | Unclear | ERK-MAPK | -- | ncRNA | Fibroblast | Foreskin | Aging | Accelerate | | L | 28487970 |
| Sen_G_1191 | MIR30C1 | 407031 | CHD7//TNRC6A//P16//P53 | Downregulation//Downregulation//Downregulation//Downregulation | Unclear | -- | -- | ncRNA | BJ | Pancreas | Aging | Prevent | | L | 29907771 |
| Sen_G_1192 | MIR34A | 407040 | SIRT1 | Downregulation | Unclear | -- | -- | ncRNA | U87,MSC | -- | Aging | Accelerate | | L | 30592284 |
| Sen_G_1193 | MIR34A | 407040 | -- | -- | Unclear | -- | -- | ncRNA | ADSC | -- | Aging | Accelerate | | HL | 26677981 |
| Sen_G_1194 | MIR377 | 494326 | DNMT1//P53 | Downregulation//Upregulation | Unclear | -- | -- | ncRNA | HSF | -- | Aging | Accelerate | | HL | 28277545 |
| Sen_G_1195 | MIR15B | 406949 | SIRT4 | Downregulation | Unclear | -- | -- | ncRNA | HDF | -- | Aging | Prevent | | HL | 26959556 |
| Sen_G_1196 | MIR1292 | 100302138 | FZD4 | Downregulation | Unclear | WNT-β-CATENIN | Downregulation | ncRNA | Adipose stromal cell | -- | Age-related osteoporosis | Accelerate | | L | 30574422 |
| Sen_G_1197 | CIRCPVT1 | -- | LET-7 | Downregulation | Unclear | -- | -- | ncRNA | WI-38 | -- | Aging | Prevent | | HL | 27928058 |
| Sen_G_1198 | MEG3 | 55384 | -- | -- | Unclear | -- | -- | ncRNA | HUVEC | Blood | Aging | Prevent | | L | 30576236 |
| Sen_G_1199 | MIR15B | 406949 | LPAR3 | Downregulation | Unclear | PI3K-AKT | Downregulation | ncRNA | ES‐2,Caov‐4,SKOV3,OVCAR-3,OV‐1063 | -- | Ovarian cancer | Accelerate | | HL | 31140597 |
| Sen_G_1200 | MIR183 | 406959 | -- | -- | Unclear | -- | -- | ncRNA | HTM,HDF,HeLa | -- | Aging | Accelerate | | HL | 27116545 |
| Sen_G_1201 | MIR675 | 100033819 | -- | -- | Unclear | TGFβ1-P21 | Downregulation | ncRNA | H9C2 | -- | Vascular disease | Prevent | | L | 30889706 |
| Sen_G_1202 | LNCTAM34A | 102724571 | -- | -- | Unclear | P53 | -- | ncRNA | HCT116 | Colon | Aging | Prevent | | HL | 29593331 |
| Sen_G_1203 | MIR21 | 406991 | IL1B//ICAM-1//PLAT | Downregulation//--//Downregulation | Unclear | -- | -- | ncRNA | MCF-7 | -- | Breast cancer | Prevent | | HL | 21131358 |
| Sen_G_1204 | ACSL5 | 51703 | -- | -- | Unclear | -- | -- | ncRNA | RT4,RT-112,Urotsa | Tumor tissue | Bladder cancer | Accelerate | | L | 23348389 |
| Sen_G_1205 | MIR146A | 406938 | PAI-1//IRAK1 | Inhibition//-- | Unclear | -- | -- | ncRNA | HTM636,HTM1073 | -- | Aging | Prevent | | HL | 20053980 |
| Sen_G_1206 | MIR138-1 | 406929 | TERT | Downregulation | Unclear | -- | -- | ncRNA | HuH-7,HepG2,Hepatocyte | -- | Hepatocellular carcinoma | Accelerate | | L | 28258280 |
| Sen_G_1207 | MIR101-1 | 406893 | UBE2N//SMARCA4 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | MCF-7 | -- | Aging | Accelerate | | HL | 25353636 |
| Sen_G_1208 | HOTAIR | 100124700 | ATAXIN-1//SNURPORTIN-1 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | WI-38,IDH4 | -- | Aging | Accelerate | | L | 24326307 |
| Sen_G_1209 | MALAT1 | 378938 | ABI3BP//EZH2 | Downregulation//-- | Methylation | -- | -- | ncRNA | GBC-SD,SGC-996 | -- | Gallbladder cancer | Prevent | | HL | 31174563 |
| Sen_G_1210 | SNHG6 | 641638 | EZH2//P21 | Upregulation//Downregulation | Unclear | JNK | -- | ncRNA | MGC803,MKN45 | -- | Gastric cancer | Prevent | | L | 30031062 |
| Sen_G_1211 | MIR127 | 406914 | BCL6 | Downregulation | Unclear | P53-P21 | Upregulation | ncRNA | WI-38,IMR-90 | -- | Aging | Accelerate | | L | 24282530 |
| Sen_G_1212 | MIR449B | 693123 | -- | -- | Unclear | P53 | Activation | ncRNA | SNU638 | -- | Gastric cancer | Accelerate | | HL | 21418558 |
| Sen_G_1213 | MIR150 | 406942 | -- | -- | Unclear | PI3K-AKT | Downregulation | ncRNA | Normal NK/T-cell Lymphoma cell line cell,HANK-1,MOTN-1,SNK-6 | -- | Malignant lymphoma | Accelerate | | L | 21502955 |
| Sen_G_1214 | MIR338 | 442906 | -- | -- | Unclear | FOXD1//MAPK | Downregulation//Downregulation | ncRNA | U251 | Brain | Malignant glioma | Accelerate | | HL | 30225541 |
| Sen_G_1215 | MIR195 | 406971 | CCND3//BIRC5 | Downregulation//Downregulation | Unclear | RB | Activation | ncRNA | H1299,H1993,H358 | -- | Lung cancer | Accelerate | | HL | 29416000 |
| Sen_G_1216 | MIR380 | 494329 | P21 | Downregulation | Unclear | P53 | Downregulation | ncRNA | Mammary epithelial cell | Mammary Gland | Neuroblastoma | Prevent | | L | 20871609 |
| Sen_G_1217 | MIR34A | 407040 | SIRT1//P53//P21 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | ECa-109 | -- | Endometrial cancer | Accelerate | | L | 26523671 |
| Sen_G_1218 | SNHG6 | 641638 | -- | -- | Unclear | -- | -- | ncRNA | SK-BR-3,MDA-MB-231 | -- | Breast cancer | Prevent | | L | 30826970 |
| Sen_G_1219 | MIR125A | 406910 | -- | -- | Unclear | -- | -- | ncRNA | HBMEC | -- | Aging | Prevent | | L | 27903586 |
| Sen_G_1220 | MIR30D | 407033 | -- | -- | Unclear | -- | -- | ncRNA | OVCAR-5,OWA42,MDA-MB-231,T47D,HCT116 | -- | Cancer | Prevent | | HL | 22058146 |
| Sen_G_1221 | MIR1258 | 100302172 | -- | -- | Unclear | GRB2-RAS-ERK | Downregulation | ncRNA | H1299 | -- | Lung cancer | Accelerate | | L | 30069987 |
| Sen_G_1222 | VIM-AS1 | 100507347 | -- | -- | Unclear | -- | -- | ncRNA | SW1116,SW480,HT29,SW48 | -- | Colorectal cancer | Prevent | | L | 29656793 |
| Sen_G_1223 | MIR192 | 406967 | -- | -- | Unclear | -- | -- | ncRNA | HCT116,A549 | -- | Colorectal cancer | Accelerate | | HL | 19074875 |
| Sen_G_1224 | MIR215 | 406997 | -- | -- | Unclear | -- | -- | ncRNA | HCT116,A549 | -- | Colorectal cancer | Accelerate | | HL | 19074875 |
| Sen_G_1225 | MIR101-1 | 406893 | EZH2//MCL-1//FOS | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | ncRNA | SPAC-1-L,HEC-50 | -- | Endometrial cancer | Accelerate | | HL | 25153722 |
| Sen_G_1226 | MIR155 | 406947 | -- | -- | Unclear | SIRT1-FOXO1-P53-P21 | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 31752013 |
| Sen_G_1227 | MIR34A | 407040 | -- | -- | Unclear | -- | -- | ncRNA | A549 | -- | Idiopathic Pulmonary Fibrosis | Accelerate | | HL | 27362652 |
| Sen_G_1228 | MIR34A | 407040 | -- | -- | Unclear | E2F//P53 | Downregulation//Upregulation | ncRNA | HCT116,RKO | -- | Colorectal cancer | Accelerate | | HL | 17875987 |
| Sen_G_1229 | MIR29A | 407021 | H4K20ME3 | Downregulation | Unclear | -- | -- | ncRNA | MEF | Embryo | Aging | Accelerate | | L | 29967491 |
| Sen_G_1230 | TERC | 7012 | -- | -- | Unclear | -- | -- | ncRNA | Squamous cell | Tumor tissue | Skin cancer | Accelerate | | HL | 21593138 |
| Sen_G_1231 | MIR22 | 407004 | MDC1//AKT1 | Downregulation//-- | Unclear | -- | -- | ncRNA | MCF-7,MDA-MB-231,SiHa | -- | Aging | Accelerate | | HL | 25627978 |
| Sen_G_1232 | BMP2 | 650 | SMAD1//SMAD6 | Upregulation//Upregulation | Methylation | -- | -- | protein coding | RasV12 | -- | Aging | Accelerate | | HL | 22072987 |
| Sen_G_1233 | MIR1827 | 100302217 | MDM2//P53 | Downregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116,RKO | -- | Colorectal cancer | Accelerate | | HL | 26840028 |
| Sen_G_1234 | MIR23A | 407010 | TRF2 | Downregulation | Unclear | -- | -- | ncRNA | PBMC | Blood | Coronary artery disease | Accelerate | | HL | 28646123 |
| Sen_G_1235 | MIR494 | 574452 | C-MYC//SIRT1 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | AsPC-1,PANC-1 | -- | Pancreatic cancer | Accelerate | | L | 25965392 |
| Sen_G_1236 | MIR19B1 | 406980 | P53 | Downregulation | Unclear | -- | -- | ncRNA | Hela,MCF-7 | -- | Cancer | Prevent | | L | 24742936 |
| Sen_G_1237 | MIR30D | 407033 | P53//P21 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | 293T,H1299,HCT116 | -- | Cancer | Prevent | | L | 20935678 |
| Sen_G_1238 | MIR25 | 407014 | P53//P21 | Downregulation//Downregulation | Unclear | -- | -- | ncRNA | 293T,H1299,HCT116 | -- | Cancer | Prevent | | L | 20935678 |
| Sen_G_1239 | MIR339 | 442907 | MDM2//P21//P53 | Downregulation//Upregulation//Upregulation | Unclear | -- | -- | ncRNA | HCT116 | -- | Colorectal cancer | Accelerate | | L | 25193859 |
| Sen_G_1240 | MIR200C | 406985 | ZEB1 | Downregulation | Unclear | -- | -- | ncRNA | HUVEC | -- | Aging | Accelerate | | L | 21527937 |
| Sen_G_1241 | MIR34A | 407040 | SIRT1 | Downregulation | Unclear | -- | -- | ncRNA | A549,BEAS-2B | -- | Idiopathic pulmonary fibrosis | Accelerate | | L | 27979858 |
| Sen_G_1242 | MIR34A | 407040 | DLL1 | Downregulation | Unclear | PI3K-AKT | Downregulation | ncRNA | Chondrocyte | Bone | Osteoarthritis | Accelerate | | L | 30048987 |
| Sen_G_1243 | MIR34C | 407042 | RAB27B | --//-- | Unclear | -- | -- | ncRNA | KG-1a | -- | Leukemia | Accelerate | | HL | 29479064 |
| Sen_G_1244 | MIR106B | 406900 | EP300 | Downregulation | Unclear | -- | -- | ncRNA | MTMEC | -- | Breast cancer | Prevent | | HL | 24270410 |
| Sen_G_1245 | MIR31 | 407035 | BMI1 | Downregulation | Unclear | -- | -- | ncRNA | MDA-MB-231,MCF-7,MRC-5 | -- | Aging | Accelerate | | HL | 25737447 |
| Sen_G_1246 | DPP4 | 1803 | -- | -- | Phosphorylation | AMPK-SIRT1-NRF2 | Activation | protein coding | HUVECs | -- | Aging | Accelerate | | L | 32251672 |
| Sen_G_1247 | PIM1 | 5292 | -- | -- | Phosphorylation | TGFβ | Downregulation | protein coding | Cardiomyocytes | -- | Aging | Prevent | | L | 32176281 |
| Sen_G_1248 | IRX5 | 10265 | -- | -- | Unclear | ATM | Activation | protein coding | SW480 | -- | Aging | Accelerate | | L | 32162364 |
| Sen_G_1249 | MTOR | 2475 | AKT1 | Upregulation | Phosphorylation | -- | -- | protein coding | Fibroblasts | -- | Aging | Accelerate | | L | 31931659 |
| Sen_G_1250 | HNRNPF | 3185 | TCAB1//HTERC | --//-- | Unclear | -- | -- | protein coding | hMSCs | -- | Aging | Prevent | | L | 31863069 |
| Sen_G_1251 | CGRP | 796 | -- | -- | Unclear | MAPK//NF-κB | Activation//Activation | protein coding | NPCs | -- | Intervertebral disc degeneration | Accelerate | | L | 34987701 |
| Sen_G_1252 | PRKG1-AS1 | 100506939 | MYOD//MYOG//MEF2C | Downregulation | Unclear | -- | -- | ncRNA | Myoblasts | Skeletal muscle | Aging | Accelerate | | HL | 34051073 |
| Sen_G_1253 | MIR99B | 407056 | MFG-E8 | Downregulation | Unclear | P65 NF-ΚB | Activation | ncRNA | Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 34031369 |
| Sen_G_1254 | MFGE8 | 4240 | -- | -- | Unclear | P65 NF-κB | Downregulation | protein coding | Chondrocyte | -- | Osteoarthritis | Prevent | | L | 34031369 |
| Sen_G_1255 | TBK1 | 29110 | -- | -- | Unclear | -- | -- | protein coding | NPCs | -- | Intervertebral disc degeneration | Prevent | | L | 34026282 |
| Sen_G_1256 | CDK4 | 1019 | PERK | Upregulation | Phosphorylation | -- | -- | protein coding | BxPC-3,Panc-1,MiaPaCa-2 | -- | Aging | Prevent | | L | 34001634 |
| Sen_G_1257 | CDK6 | 1021 | PERK | Upregulation | Phosphorylation | -- | -- | protein coding | BxPC-3,Panc-1,MiaPaCa-2 | -- | Aging | Prevent | | L | 34001634 |
| Sen_G_1258 | BRAF | 673 | -- | -- | Unclear | MTOR | Activation | protein coding | HPCs,LCH cells | -- | Langerhans cell histiocytosis | Accelerate | | HL | 33958797 |
| Sen_G_1259 | TNF | 7124 | TRAIL//IL6 | Upregulation//Upregulation | Unclear | -- | -- | protein coding | A375,HT29 | -- | Melanoma | Accelerate | | L | 33957885 |
| Sen_G_1260 | ATG5 | 9474 | -- | -- | Unclear | -- | -- | protein coding | NPCs | -- | Intervertebral disc degeneration | Prevent | | L | 33921398 |
| Sen_G_1261 | DKC1 | 1736 | TERC | Upregulation | Unclear | -- | -- | protein coding | A549 cells,PC-9 cells | -- | Aging | Prevent | | HL | 33879171 |
| Sen_G_1262 | CXCR2 | 3579 | -- | -- | Unclear | P38-ERK MAPK | Activation | protein coding | LL2 cells,H460 cells | -- | Lung cancer | Prevent | | HL | 33814009 |
| Sen_G_1263 | BMP5 | 653 | -- | -- | Unclear | P38-ERK | Activation | protein coding | Chondrocytes | -- | Osteoarthritis | Accelerate | | L | 33744859 |
| Sen_G_1264 | CRY1 | 1407 | P53 | Downregulation | Unclear | -- | -- | protein coding | UMUC3 Res cells,EJ Res cells | -- | Bladder cancer | Prevent | | L | 33650658 |
| Sen_G_1265 | MIR340 | 442908 | POT1 | Downregulation | Unclear | -- | -- | ncRNA | HT22 | -- | Alzheimer's disease | Prevent | | L | 33624913 |
| Sen_G_1266 | SIRT6 | 51548 | HTERT | Upregulation | Unclear | -- | -- | protein coding | LFH cells | -- | Lumbar spinal stenosis | Prevent | | HL | 33568575 |
| Sen_G_1267 | MIR130A | 406919 | -- | -- | Unclear | -- | -- | ncRNA | SH-SY5Y | -- | Aging | Prevent | | L | 33964346 |
| Sen_G_1268 | AHNAK | 79026 | 53BP1 | -- | Unclear | P53 | Downregulation | protein coding | BJ cells | -- | Aging | Prevent | | HL | 33961796 |
| Sen_G_1269 | CD276 | 80381 | TM4SF1 | Upregulation | Unclear | AKT-TM4SF1-SIRT1 | Upregulation | protein coding | HCT116,RKO | -- | Colorectal cancer | Prevent | | HL | 33958586 |
| Sen_G_1270 | MIR27B | 407019 | KDM4B | Downregulation | Unclear | -- | -- | ncRNA | B-MSC | -- | Osteoarthritis | Accelerate | | HL | 32856377 |
| Sen_G_1271 | MTX2 | 10651 | MTX1 | Upregulation | Unclear | -- | -- | protein coding | Primary Fibroblast | -- | Mandibuloacral dysplasia | Prevent | | HL | 32917887 |
| Sen_G_1272 | MIR29A | 407021 | DNMT3A | Downregulation | Methylation | -- | -- | ncRNA | HMSC | -- | Aging | Prevent | | HL | 32961441 |
| Sen_G_1273 | MIR30C1 | 407031 | DNMT3A | Downregulation | Methylation | -- | -- | ncRNA | HMSC | -- | Aging | Prevent | | HL | 32961441 |
| Sen_G_1274 | PIK3R3 | 8503 | P53 | -- | Unclear | P53-P21 | Downregulation | protein coding | LoVo,SW48 | -- | Colorectal cancer | Prevent | | L | 32973127 |
| Sen_G_1274 | PIK3R3 | 8503 | P53 | Inhibition | Binding to promoter | P53-P21 | Downregulation | protein coding | LoVo,SW48 | -- | Colorectal cancer | Prevent | | L | 32973127 |
| Sen_G_1275 | POLR3A | 11128 | -- | -- | Unclear | -- | -- | protein coding | fibroblast | -- | Wiedemann-Rautenstrauch syndrome (WRS) | Prevent | | L | 32976914 |
| Sen_G_1276 | CDKN2B-AS1 | 100048912 | CDKN2B | Downregulation | Unclear | -- | -- | ncRNA | HEK293T,HTM | -- | POAG | Prevent | | HL | 32825664 |
| Sen_G_1277 | FOXO4 | 4303 | -- | -- | Unclear | -- | -- | protein coding | UC-MSC | -- | Aging | Accelerate | | L | 32820304 |
| Sen_G_1278 | LMNA | 4000 | METTL3/14 | Upregulation | Unclear | -- | -- | protein coding | HSF,MEF | -- | HGPS | Prevent | | L | 32813328 |
| Sen_G_1279 | MIR483 | 619552 | IGF1 | Downregulation | Unclear | -- | -- | ncRNA | ADSC | -- | Aging | Accelerate | | HL | 32805717 |
| Sen_G_1280 | CLOCK | 9575 | LAMIN B1,EMERIN,KAP1 | --//--//-- | Unclear | -- | -- | protein coding | HMSC | -- | Aging | Prevent | | HL | 32737416 |
| Sen_G_1281 | SIRT1 | 23411 | -- | -- | Unclear | -- | -- | protein coding | NP | -- | IVDD | Prevent | | L | 32687063 |
| Sen_G_1282 | MIR185 | 406961 | POT1 | Upregulation | Unclear | ATR | Downregulation | ncRNA | HTC75,HFF,MRC5 | -- | Aging | Accelerate | | L | 32687062 |
| Sen_G_1283 | ERG | 2078 | P53 | Upregulation | Unclear | -- | -- | protein coding | LNCaP | -- | Aging | Prevent | | HL | 32674955 |
| Sen_G_1284 | MIB1 | 57534 | WRN | Downregulation | Ubiquitylation | -- | -- | protein coding | HCT116,HEK293T | -- | Aging | Accelerate | | L | 32652764 |
| Sen_G_1285 | MIR34A | 407040 | -- | -- | Unclear | -- | -- | ncRNA | HADMSC | -- | Aging | Accelerate | | L | 32634429 |
| Sen_G_1286 | IQGAP1 | 8826 | -- | -- | Unclear | -- | -- | protein coding | VMSC | -- | Aging | Prevent | | L | 32592713 |
| Sen_G_1287 | NSD2 | 7468 | -- | -- | Unclear | RB | -- | protein coding | IMR-90 | -- | Aging | Prevent | | HL | 32573059 |
| Sen_G_1288 | RTEL1 | 51750 | -- | -- | Unclear | -- | -- | protein coding | fibroblast | -- | HHS | Prevent | | L | 32542379 |
| Sen_G_1289 | SIRT7 | 51547 | LINE1 | Inhibition | Unclear | CGAS-STING | Downregulation | protein coding | HMSC | -- | Aging | Prevent | | L | 32504224 |
| Sen_G_1290 | ZKSCAN3 | 80317 | LAMIN B1,LBR,KAP1,HP1α | Upregulation//Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | HMSC | Muscles of nude mice | Aging | Prevent | | HL | 32427330 |
| Sen_G_1291 | MFN2 | 9927 | PARKIN | Downregulation | Ubiquitylation | -- | -- | protein coding | Chondrocyte | -- | Osteoarthritis | Accelerate | | L | 32416221 |
| Sen_G_1292 | FBP1 | 2203 | HMGB1 | Upregulation | Unclear | -- | -- | protein coding | HSC | -- | Aging | Accelerate | | HL | 32367049 |
| Sen_G_1293 | MIR21 | 406991 | PTEN | Downregulation | Unclear | PTEN/PI3K-NRF2 | Activation | ncRNA | CD4+T,HEK293T | -- | Aging | Prevent | | HL | 34887868 |
| Sen_G_1294 | MIF | 4282 | -- | -- | Unclear | -- | -- | protein coding | Primary Human NP Cells | Nucleus pulposus | Intervertebral disc degeneration | Prevent | | L | 34306312 |
| Sen_G_1295 | UNC5B | 219699 | -- | -- | Unclear | P53 | Activation | protein coding | HUVEC | -- | Aging | Accelerate | | L | 34239689 |
| Sen_G_1296 | CARTPT | 9607 | -- | -- | Unclear | -- | -- | protein coding | Primary cortical neurons | Cortex | AD | Prevent | | L | 33610183 |
| Sen_G_1297 | SIRT3 | 23410 | -- | -- | Unclear | AMPK-PGC‐1α | Activation | protein coding | NP Cells | Nucleus pulposus | Intervertebral disc degeneration | Prevent | | L | 33565085 |
| Sen_G_1298 | EGR2 | 1959 | ARF//P16 | Upregulation | Binding to promoter | P16-PRB//ARF-P53-P21 | Activation | protein coding | DS HMFs | -- | Aging | Accelerate | | HL | 33547862 |
| Sen_G_1299 | ITPR2 | 3709 | -- | -- | Unclear | -- | -- | protein coding | MRC5 | -- | Aging | Accelerate | | HL | 33526781 |
| Sen_G_1300 | DKC1 | 1736 | -- | -- | Unclear | -- | -- | protein coding | CD34+ cells | -- | Dyskeratosis congenita | Prevent | | L | 33514435 |
| Sen_G_1301 | FOXO1 | 2308 | BACH2//AP-1 | Upregulation//Downregulation | Unclear | -- | -- | protein coding | CD8+T | -- | Aging | Prevent | | HL | 33503413 |
| Sen_G_1302 | YAP1 | 10413 | P21 | Downregulation | Unclear | YAP-P21 | Downregulation | protein coding | SW 1353,Hs 819.T,Chondrocyte | knee | Chondrosarcoma | Prevent | | HL | 33495462 |
| Sen_G_1303 | RPPH1 | 85495 | MLC1 MRNA//CCR7 MRNA | Upregulation | Unclear | -- | -- | ncRNA | WI-38,IDH4 | -- | Aging | Accelerate | | HL | 33466722 |
| Sen_G_1304 | CLIC1 | 1192 | NRF2 | Downregulation | Unclear | NRF2-HO1//AMPK-AKT-GSK3β | Downregulation | protein coding | HUVECs | -- | Aging | Accelerate | | L | 33432550 |
| Sen_G_1305 | SMAD4 | 4089 | -- | -- | Unclear | TGF-β/SMAD-IFNγ | Activation | protein coding | Fibroblast | -- | Aging | Prevent | | L | 33428109 |
| Sen_G_1306 | MT-CO2 | 4513 | -- | -- | Unclear | -- | -- | protein coding | HMSCs | -- | Aging | Prevent | | L | 33416107 |
| Sen_G_1307 | MIR217 | 406999 | SIRT1 | Downregulation | Unclear | SIRT1-P53 | Activation | ncRNA | HUVECs | -- | Aging | Accelerate | | L | 33392891 |
| Sen_G_1308 | TWIST1 | 7291 | -- | -- | Unclear | P53-P21 | Downregulation | protein coding | NP Cells | Nucleus pulposus | Disc degeneration | Prevent | | L | 33378011 |
| Sen_G_1309 | TWIST2 | 117581 | -- | -- | Unclear | P53-P21 | Downregulation | protein coding | NP Cells | Nucleus pulposus | Disc degeneration | Prevent | | L | 33378011 |
| Sen_G_1310 | CDK2 | 1017 | MYC | Upregulation | Phosphorylation | -- | -- | protein coding | Phoenix-Eco | -- | Leukemia | Prevent | | L | 33356836 |
| Sen_G_1311 | CFL1 | 1072 | TEAD1 | Downregulation | Unclear | -- | -- | protein coding | WI-38 | -- | Aging | Accelerate | | L | 33336885 |
| Sen_G_1312 | GATA6 | 2627 | -- | -- | Unclear | SHH-FOXP1 | Downregulation | protein coding | iPSC-MSC | -- | Aging | Accelerate | | HL | 33252174 |
| Sen_G_1313 | PDK1 | 5163 | MTOR//NF-κB | Upregulation | Unclear | -- | -- | protein coding | NHDF | -- | Aging | Accelerate | | HL | 33229519 |
| Sen_G_1314 | SLX4IP | 128710 | -- | -- | Unclear | -- | -- | protein coding | DU145,PC-3 | -- | CRPC | Prevent | | L | 33188147 |
| Sen_G_1315 | MEG3 | 55384 | MIR-16-5P | Inhibition | Unclear | MIR-16-5P-VGLL4 | Activation | ncRNA | A549,MCF-7 | -- | Aging | Accelerate | | HL | 33141998 |
| Sen_G_1316 | NEAT1 | 283131 | MIR-221-3P | Inhibition | Unclear | -- | -- | ncRNA | BM-MSC | -- | Aging | Prevent | | HL | 33129330 |
| Sen_G_1317 | HEIH | 100859930 | MIR-3619-5P | Downregulation | Unclear | MIR-3619-5P-CTTNBP2 | Downregulation | ncRNA | OVCA429,OVCA433,OVCAR3 | -- | Ovarian cancer | Prevent | | L | 33110047 |
| Sen_G_1318 | SNHG29 | 125144 | -- | -- | Unclear | P53-P21 | Activation | ncRNA | HTR8/SVneo | -- | Preterm birth | Accelerate | | L | 33080448 |
| Sen_G_1319 | METTL3 | 56339 | MIS12 | Downregulation | Methylation | -- | -- | protein coding | hMSCs | -- | Progeroid syndromes | Prevent | | HL | 33035345 |
| Sen_G_1320 | HES1 | 3280 | -- | -- | Unclear | -- | -- | protein coding | Dermal fibroblasts | Skin | Aging | Prevent | | HL | 33238152 |
| Sen_G_1321 | KLF6 | 1316 | -- | -- | Unclear | -- | -- | protein coding | Dermal fibroblasts | Skin | Aging | Prevent | | HL | 33238152 |
| Sen_G_1322 | PPARA | 5465 | GDF11 | Upregulation | Unclear | -- | -- | protein coding | EA.hy926,HUVEC | -- | Atherosclerosis | Prevent | | L | 33728018 |
| Sen_G_1323 | SGK1 | 6446 | -- | -- | Unclear | -- | -- | protein coding | Glial cell | -- | Parkinson disease | Accelerate | | HL | 33646633 |
| Sen_G_1324 | LINC00858 | 170425 | WNK2 | Upregulation | Unclear | -- | -- | ncRNA | HCT116 | Colon cancer tissues | Colorectal cancer | Prevent | | HL | 32768499 |
| Sen_G_1325 | CD70 | 970 | -- | -- | Unclear | -- | -- | protein coding | T cell | -- | Aging | Accelerate | | L | 32559178 |
| Sen_G_1326 | SETMAR | 6419 | -- | -- | Unclear | -- | -- | protein coding | U87MG,SF268 | -- | Glioblastoma | Prevent | | HL | 32458986 |
| Sen_G_1327 | CD9 | 928 | -- | -- | Unclear | PI3K-AKT-MTOR-P53 | Activation | protein coding | HUVEC | -- | Aging | Accelerate | | L | 32346137 |
| Sen_G_1328 | FBP1 | 2203 | HMGB1 | Upregulation | Unclear | -- | -- | protein coding | HSC | -- | Aging | Accelerate | | HL | 32367049 |
| Sen_G_1329 | WISP1 | 8840 | -- | -- | Unclear | -- | -- | protein coding | Chondrocyte | Cartilage tissues | Osteoarthritis | Prevent | | L | 33646053 |
| Sen_G_1330 | PPAR | 5465 | PPAR-α//PPAR-β/δ//TFEB | Downregulation//Downregulation//Downregulation | Unclear | -- | -- | protein coding | -- | Great saphenous vein wall | Chronic venous disorder | Prevent | | HL | 33645625 |
| Sen_G_1331 | RECQL4 | 9401 | C-MYC//CYCLIND//CDK6//CYCLINE | Downregulation//Downregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | KYSE30,KYSE450,KYSE410,KYSE150,TE-1 | ESCC tissues | Esophageal cancer | Accelerate | | HL | 33628589 |
| Sen_G_1332 | ATM | 472 | -- | -- | Unclear | -- | -- | protein coding | HFMs | Human haired scalp | Aging | Prevent | | L | 33128003 |
| Sen_G_1333 | SENEX | 93663 | -- | -- | Unclear | P16-RB | Activation | protein coding | OCI‐LY8 | -- | r/r DLBCL | Accelerate | | L | 33015970 |
| Sen_G_1334 | HBP1 | 26959 | -- | -- | Unclear | -- | -- | protein coding | NP Cells | -- | Intervertebral disc degeneration | Accelerate | | L | 32964956 |
| Sen_G_1335 | BRD4 | 23476 | AURKA//AURKB | Upregulation | Unclear | -- | -- | protein coding | KYSE450 | -- | Oesophageal cancer | Prevent | | L | 32954665 |
| Sen_G_1336 | MDM2 | 4193 | -- | -- | Unclear | -- | -- | protein coding | MCF-7 | -- | Breast ?cancer | Accelerate | | HL | 32787886 |
| Sen_G_1337 | ASIC1 | 41 | P53//P21//P27//RB1//P16//MMP3//MMP9 | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | NP-MSCs | -- | Aging | Accelerate | | L | 33824228 |
| Sen_G_1338 | ASIC3 | 9311 | P53//P21//P27//RB1//P16//MMP3//MMP9 | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Upregulation | Unclear | -- | -- | protein coding | NP-MSCs | -- | Aging | Accelerate | | L | 33824228 |
| Sen_G_1339 | LINC-PINT | 378805 | FOXM1//PHB2 | Downregulation//Downregulation | Binding to promoter | -- | -- | ncRNA | HCC,SPHC,SMMC-7721,MHCC-97H | -- | Hepatocellular carcinoma | Accelerate | | L | 33754036 |
| Sen_G_1340 | STING1 | 340061 | -- | -- | Unclear | NF-κB | Activation | protein coding | Chondrocytes | -- | Osteoarthritis | Accelerate | | L | 33414452 |
| Sen_G_1341 | EZH2 | 2146 | NGF | Upregulation | Unclear | -- | -- | protein coding | Chondrocytes | Human cartilage explants | Osteoarthritis | Accelerate | | L | 33177650 |
| Sen_G_1342 | MIR126 | 406913 | PTEN | Downregulation | Unclear | AKT | Activation | ncRNA | DPSCs | -- | Aging | Accelerate | | HL | 33150661 |
| Sen_G_1343 | NFKBIA | 4792 | -- | -- | Unclear | -- | -- | protein coding | HDFs | -- | Aging | Prevent | | HL | 33459422 |
| Sen_G_1344 | EZH2 | 2146 | -- | -- | Unclear | TGF-β-SMAD | Downregulation | protein coding | HSCs,JS1,LX-2 | -- | Aging | Prevent | | HL | 33391480 |
| Sen_G_1345 | KDM6B | 23135 | -- | -- | Unclear | -- | -- | protein coding | HSCs,JS1 | -- | Aging | Accelerate | | HL | 33391480 |