| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HuH-7,Hep3B |
| Gene ID: | 51548 |
| Category: | protein coding |
| Phenotype: | Hepatocellular carcinoma |
| Experimental category: | HL |
| PMID: | 27824900 |
| Experiment: | SA-β-gal activity assay//qRT-PCR//Cell morphological analysis |
| Description: | SIRT6-silenced cells were flattened and larger with the characteristic morphology of cellular senescence[17]. The percentages of SIRT6-depleted HCC cells positively stained with SA-β-gal were 29.1 4.9% (shSIRT6-1) and 16.2 8.4% (shSIRT6-3) Hep3B cells and 29.3 5.2% (shSIRT6-1) and 17.1 6.3% (shSIRT6-1) Huh-7 cells, while that of control HCC cells positively stained with SA-β-gal was less than 1.0% Hep3B cells and 6.1% Huh-7 cells. SIRT6 silencing increased mRNA levels of IL8, CXCL1, CXCL2 and CXCL3 . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...