| Gene name: | MDM2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | LS8817 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | It is well known that enforced expression of MDM2 does not increase its abundance in cycling cells; however, enforced expression did prevent the PD0332991-induced reduction in MDM2. Accumulation of phospho-Rb and cyclin A were also reduced.However, it prevented the CDK4i-induced accumulation of SA-β-gal positive cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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