| Gene name: | MIR34A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | TIG3 TERT/B-RAF:ER |
| Experiment: | Cell cycle analysis//Cell morphological analysis |
| Description: | Cells overexpressing miR-34a exhibited a senescence-like morphology.Overexpression of miR-34a reduced cellular proliferation. |
| Target gene: | B-RAFONCOGENE//ELK1//MYC |
| Official symbol(s): | B-RAFONCOGENE//ELK1//MYC |
| R-AG-Target gene: | --//--//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qPCR//Knockdown//Western blot |
| Target gene description: | miR-34a was approximately eightfold upregulated after 3 days of B-RAF activation. ER cells using siRNA and measured miR-34a regulation after B-RAF activation，depletion of ELK1 significantly impaired B-RAF-mediated induction of miR-34a(P<0.04, Student's t-test). Strikingly, miR-34a overexpression resulted in marked downregulation of endogenous MYC protein. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...