| Gene name: | RBP2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | AGS,HeLa,SiHa,HGC-27,BGC-823 |
| Gene ID: | 5948 |
| Category: | protein coding |
| Phenotype: | Gastric cancer |
| Experimental category: | L |
| PMID: | 19850045 |
| Experiment: | SA-β-gal activity assay//BrdU assay |
| Description: | Significant fractions of the cells treated with RBP2 siRNA became positive for SA-β-Gal staining. Consistent with positive SA-β-Gal staining, these RBP2-depleted cells exhibited significantly lower BrdU labeling than did control cells. |
| Target gene: | P16//P21//P27 |
| Official symbol(s): | P16//P21//P27 |
| R-AG-Target gene: | --//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR//SA-β-gal activity assay |
| Target gene description: | p16ink4a, p21CIP1, and p27kip1 promoter activity significantly increased following RBP2 depletion in AGS and BGC cells. In contrast, cotransfection with the RBP2 expression vector led to a substantially declined activity of all 3 promoters. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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