| Gene name: | EZH2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MKN28 |
| Gene ID: | 2146 |
| Category: | protein coding |
| Phenotype: | Gastric cancer |
| Experimental category: | L |
| PMID: | 24738879 |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Knockdown |
| Description: | To further elucidate reasons why inhibiting EZH2 promoted DOX-induced cell proliferation inhibition, wecounted cells positive for SA-β-gal expression, and observed SAHF formation again. In MKN28 cells carrying mutant p53, siRNA and EGCG caused marked increase in positive level of SA-β-gal staining and SAHF and there was increase in percentage of G0/G1 phase cells.These results suggested that EZH2 depletion promoted DOX-induced senescence in MKN28 cells. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | EZH2 depletion increased accumulation of p53 protein and protein of its target gene p21, in AGS cells under co-treatment. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...