Aging Overview

Aging gene

Gene name: WIF1
Aging type: Accelerate
Aging characteristic:
Tissue type: Primary salivary gland tumor
Cell name: PA116,CaExPA79
Gene ID: 11197
Category: protein coding
Phenotype: Salivary gland tumor
Experimental category: L
PMID: 24853424
Experiment: SA-β-gal activity assay//Cell proliferation assay//Cell cycle analysis
Description: Re-expression of WIF1 resulted in a significant growth inhibition (P<0.0001) in both PA and CaExPA cells at all time points.Cells were stained for senescence-associated beta-galactosidase (SA-β-gal). WIF1 increased the number of SA-β-gal-positive cells (P<0.0001) compared with vector.


Regulatory relationship

Target gene: P53//P21
Official symbol(s): P53//P21
R-AG-Target gene: Upregulation//Upregulation
Subcategory: Unclear
Target gene experiment: RT-PCR//Western blot
Target gene description: ?WIF1 induced a remarkable increase in both mRNA and protein expression of p53 and its target p21.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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