Gene name: | WIF1 |
Aging type: | Accelerate |
Aging characteristic: |
Tissue type: | Primary salivary gland tumor |
Cell name: | PA116,CaExPA79 |
Gene ID: | 11197 |
Category: | protein coding |
Phenotype: | Salivary gland tumor |
Experimental category: | L |
PMID: | 24853424 |
Experiment: | SA-β-gal activity assay//Cell proliferation assay//Cell cycle analysis |
Description: | Re-expression of WIF1 resulted in a significant growth inhibition (P<0.0001) in both PA and CaExPA cells at all time points.Cells were stained for senescence-associated beta-galactosidase (SA-β-gal). WIF1 increased the number of SA-β-gal-positive cells (P<0.0001) compared with vector. |
Target gene: | P53//P21 |
Official symbol(s): | P53//P21 |
R-AG-Target gene: | Upregulation//Upregulation |
Subcategory: | Unclear |
Target gene experiment: | RT-PCR//Western blot |
Target gene description: | ?WIF1 induced a remarkable increase in both mRNA and protein expression of p53 and its target p21. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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