| Gene name: | SIRT7 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38,hTRT-WI38 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | We found that shRNA depletion of SIRT7 from WI38 primary human fibroblasts led to substantial accumulation of senescent cells within days after SIRT7 depletion.Levels of the senescence marker p16 were also increased in the SIRT7-deficient cell cultures (data not shown). |
| Target gene: | SNF2H |
| Official symbol(s): | SMARCA5 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | IP |
| Target gene description: | This analysis revealed specific binding of SIRT7 to both the SNF2H and TIP5 subunits of NoRC.Intriguingly, these experiment salso revealed that overexpression of SIRT7 leads to increased SNF2H protein levels. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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