| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Heart failure |
| Experimental category: | L |
| PMID: | 28331525 |
| Experiment: | SA-β-gal activity assay |
| Description: | The inhibition of Sirt1 activity by EX-527 caused an increase of senescence in RP-ECs compared with baseline (P = 0.001). |
| Target gene: | CAT//SOD |
| Official symbol(s): | CAT//SOD1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Enzyme activity assay |
| Target gene description: | The CRP enhanced Sirt1 activity measured in PBMCs from patients (RP vs P, P= 0.02). Likewise, Cat and SOD activities measured in serum were greater in RP than in P (P < 0.005 and P < 0.05, respectively). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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