| Gene name: | TYRO3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Melanocyte |
| Experiment: | SA-β-gal activity assay//Colony formation assay |
| Description: | Expression of TYRO3 alone did not have clear effect compared to control virus infected melanocytes. Expression of BRAF(V600E) induced senescence in melanocytes and led to an increase in the percentage of senescent cells with the characteristic enlarged cell body and positive staining of senescence-associated β-galactosidase (SA-β-Gal) activity . However, when TYRO3 was co-expressed with the BRAF(V600E) mutant, primary melanocytes formed colonies in which non-senescent cells dominate the population, as indicated by a strong reduction in the percentage of SA-β-Gal positive cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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