| Gene name: | CBS |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC,HAEC,HDF |
| Experiment: | BrdU assay//Knockdown//SA-β-gal activity assay |
| Description: | CBS depletion led to decreased cell numbers in HUVEC but not HDF; it also significantly reduced the rate of cell proliferation, measured by BrdU incorporation studies, but had no effect on the rate of apoptotic cell death. CBS knockdown also reduced the proliferative capacity of human aortic endothelial cells (HAEC), included as an additional control, included as an additional control.Both in HUVEC and HAEC, CBS knockdown led to a premature accumulation of cells staining positive for senescence associated ?-galactosidase (SA-?-gal). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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