| Gene name: | CDK2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | RPE,U2OS |
| Experiment: | SA-β-gal activity assay//SAHF//Immunostaining |
| Description: | While long-term treatment with RO-3306 and NU6140 was toxic for cells, we found that all these markers were reduced upon combined Cdk1/2 RNAi or addition of Roscovitine, indicating that Cdk activity stimulates senescence. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | p21 induction was reduced upon Cdk inhibition or depletion, suggesting that the remaining Cdk activity during a DDR promotes p21 expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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