Aging Overview

Aging gene

Gene name: H1-3
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: WI-38
Gene ID: 3007
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 17158953
Experiment: BrdU assay//SA-β-gal activity assay//Cell morphological analysis
Description: Concomitant with the decreases in histone H1 protein levels, the expression of N fusions caused severe growth defects in young WI-38 cells as revealed by the growth curves and the BrdU incorporation assay. N fusions also induced a large, flat morphology and increased the percentage of SA–β-gal–positive cells, suggesting that the ectopic expression of N fusions induced premature senescence in WI-38 cells.


Regulatory relationship

Target gene: P53//P21//RB
Official symbol(s): P53//P21//RB
R-AG-Target gene: --//Upregulation//--
Subcategory: Unclear
Target gene experiment: Western blot//Cell transfection
Target gene description: Cells expressing N fusions showed decreased levels of phosphorylated Rb and cyclin A and increased levels of p21 and phosphorylated p53.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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