| Gene name: | ASF1A |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HepG2,LNCaP |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | We, thus, performed β-gal staining for senescence evaluation. Blue β-gal staining was readily seen in siASF1a-treated cells, while hardly detected in control cells, implying that knockdown of ASF1a led to senescence of HepG2 and LNCaP cells. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | Both p21cip1 and p53 were up-regulated in HCT116-Cas9 cells after ASF1a knockdown. |
Annotation:
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