| Gene name: | JUND |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Aorta |
| Cell name: | Aortic endothelial cell |
| Experiment: | Knockdown//qRT-PCR//SA-β-gal activity assay//Western blot//Immunostaining |
| Description: | Telomerase activity was blunted in young JunD?/? compared with age-matched WT mouse aorta.This finding indicated a vascular senescence phenotype in young animals lacking JunD .β-Galactosidase staining further supported the early occurrence of vascular aging in JunD?/? mice. Accordingly, the expression of aging markers such as tumor suppressor p53 and the cyclin-dependent kinase inhibitor p16INK4a was increased in these mice. |
| Target gene: | P47PHOX//NOX2//NOX4 |
| Official symbol(s): | P47PHOX//CYBB//NOX4 |
| R-AG-Target gene: | --//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Immunostaining//Western blot |
| Target gene description: | In contrast,the NADPH oxidase subunits p47phox, Nox2, and Nox4 were already upregulated in young JunD?/? mice and further increased with aging. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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