| Gene name: | GRPR |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A172 |
| Gene ID: | 2925 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | L |
| PMID: | 26780458 |
| Experiment: | Knockdown//SA-β-gal activity assay//Flow cytometry |
| Description: | GRPR knockdown reduces GBM cell proliferation.Silencing of GRPR increases significantly the percentage of senescent cells based on cell count using ImageJ. |
| Target gene: | EGFR//P38//P16//P21 |
| Official symbol(s): | EGFR//P38//P16//P21 |
| R-AG-Target gene: | --//--//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We also observed a reduction of p38 and an increase in activation of EGFR as assessed by the content of pEGFR in GRPRi cells.GRPRi cells showed increased expression levels of p53, as well as p21 and p16,suggesting that senescence was enhanced in these cells through the activation of the p53 pathway. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | GRPRi cells showed increased expression levels of p53, as well as p21 and p16,suggesting that senescence was enhanced in these cells through the activation of the p53 pathway . |
Annotation:
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