Aging Overview

Aging gene

Gene name: PLK1
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: MDA-MB-468
Gene ID: 5347
Category: protein coding
Phenotype: Breast cancer
Experimental category: L
PMID: 25505268
Experiment: SA-β-gal activity assay//Western blot//EdU assay//DAPI staining
Description: PLK1 inhibition also resulted in senescence induction and p16 up-regulation in addition to p21 up-regulation in MDA-MB-468 cells.


Regulatory relationship

Target gene: MIR-200C//MIR-141//BMI1//PRC1
Official symbol(s): MIR-200C//MIR-141//BMI1//PRC1
R-AG-Target gene: Downregulation//Downregulation//Upregulation//--
Subcategory: Unclear
Target gene experiment: qRT-PCR//Western blot//Knockdown
Target gene description: Our data indicated that indeed PLK1 knockdown results in up-regulation of miR-200c and miR-141, while PLK1 overexpression resulted in down-regulation of miR200c and miR-141 ;Our results indicated that indeed PLK1 overexpression leads to up-regulation of BMI1 and PRC1 activity.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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