Gene name: | PLK1 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | -- |
Cell name: | MDA-MB-468 |
Gene ID: | 5347 |
Category: | protein coding |
Phenotype: | Breast cancer |
Experimental category: | L |
PMID: | 25505268 |
Experiment: | SA-β-gal activity assay//Western blot//EdU assay//DAPI staining |
Description: | PLK1 inhibition also resulted in senescence induction and p16 up-regulation in addition to p21 up-regulation in MDA-MB-468 cells. |
Target gene: | MIR-200C//MIR-141//BMI1//PRC1 |
Official symbol(s): | MIR-200C//MIR-141//BMI1//PRC1 |
R-AG-Target gene: | Downregulation//Downregulation//Upregulation//-- |
Subcategory: | Unclear |
Target gene experiment: | qRT-PCR//Western blot//Knockdown |
Target gene description: | Our data indicated that indeed PLK1 knockdown results in up-regulation of miR-200c and miR-141, while PLK1 overexpression resulted in down-regulation of miR200c and miR-141 ;Our results indicated that indeed PLK1 overexpression leads to up-regulation of BMI1 and PRC1 activity. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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