Aging Overview

Aging gene

Gene name: NEDD4
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: IMR-90,2BS
Gene ID: 4734
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 23549616
Experiment: SA-β-gal activity assay
Description: Nearly all of the NEDD4-1-shRNA-infected cells displayed stronger levels of blue SA-β-gal staining similar to senescent cells, the control cells showed a lower frequency of SA-β-gal staining. However, only sporadic SA-β-gal-positive cells were seen in NEDD4-1 -transfected cells, although the corresponding vector control cells showed strong SA-β-gal staining.


Regulatory relationship

Target gene: PPARγ
Official symbol(s): PPARG
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: A high level of NEDD4-1 overexpression also caused a decrease of endogenous PPARγ protein in the Hela cells. Such a decrease of PPARγ protein level can be blocked by proteasomal inhibitor MG132;we demonstrated that endogenous NEDD4-1 negatively regulates PPARγ levels quantitatively following increased RNAi concentration.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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