| Gene name: | PML |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Gene ID: | 5371 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | HL |
| PMID: | 21205865 |
| Experiment: | Crystal violet assay//SA-β-gal activity assay |
| Description: | PML-expressing fibroblasts arrested their proliferation rapidly after selection and developed characteristics of cellular senescence, including a flat morphology, positive staining for the senescence-associated β-galactosidase (SA-β-Gal), expression of high levels of IL-8,and markers of mitochondrial dysfunction and biogenesis. |
| Target gene: | E2F//P53 |
| Official symbol(s): | E2F1//P53 |
| R-AG-Target gene: | Downregulation//-- |
| Subcategory: | Binding to promoter |
| Target gene experiment: | CHIP//qPCR |
| Target gene description: | Several E2F target genes that play a role in DNA replication, cell cycle progression, and DNA repair were found to be down-regulated in normal fibroblasts expressing PML.E2F targets were enriched sixfold among PML down-regulated genes in comparison with a random set of genes;The p53-dependant gene GADD45α was significantly up-regulated 10 d after PML expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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