| Gene name: | ID1 |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | -- |
| Cell name: | HDMEC |
| Experiment: | Cell counting//Cell morphological analysis |
| Description: | HDMECs of transduced with LZRS-empty vector (HDMEC+vector) became senescent at approximately PD17 and demonstrated the enlarged, flattened morphology seen in the untreated cells.The HDMEC+Id-1 cells demonstrated a significant increase in replicative capacity and continued to divide until PD38. |
| Regulatory pathway: | RB |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | retinoblastoma |
| Pathway experiment: | Western blot |
| Pathway description: | In contrast, HDMECs+Id-1 showed slightly lower, but sustained levels of both Rb forms until senescence, when levels of pRb and ppRb were barely detectable (not shown). |
Annotation:
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