Aging Overview

Aging gene

Gene name: CLCA2
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: MCF-7
Gene ID: 9635
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 22431922
Experiment: SA-β-gal activity assay
Description: We found an increase in positive staining for SA-β-gal in cells expressing CLCA2 compared with Mock-transfected cells.


Regulatory relationship

Target gene: P53
Official symbol(s): P53
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: qRT-PCR//Western blot//Northern blot
Target gene description: We selected CLCA2 for further analysis because CLCA2 was remarkably increased during the cellular senescence process as well as by the ectopic induction of wild-type p53 .We also confirmed the p53-mediated CLCA2 induction by quantita-tive RT-PCR, Northern, and Western blot analyses.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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