| Gene name: | KNDC1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | The levels of KNDC1 mRNA and protein in HUVECs at P4 were downregulated by gene silencing with KNDC1-siRNA1/2. Following repression of KNDC1 levels in HUVECs at P4, the size of the cells was similar to the size of P1 cells and the activity of SA-β-gal was decreased compared with that in NT-siRNA-transfected cells.The number of cells in G1 phase was decreased in cells transfected with KNDC1-siRNA. |
| Regulatory pathway: | P53-P21-P16 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53-CDKN1A-CDKN2A |
| Pathway experiment: | Western blot |
| Pathway description: | The phosphorylation of p53 and the expression of p21 and p16 decreased significantly compared with NT-siRNA-transfected control cells. |
Annotation:
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