Aging Overview

Aging gene

Gene name: KNDC1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HUVEC
Gene ID: 85442
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 24788352
Experiment: SA-β-gal activity assay//Flow cytometry
Description: The levels of KNDC1 mRNA and protein in HUVECs at P4 were downregulated by gene silencing with KNDC1-siRNA1/2. Following repression of KNDC1 levels in HUVECs at P4, the size of the cells was similar to the size of P1 cells and the activity of SA-β-gal was decreased compared with that in NT-siRNA-transfected cells.The number of cells in G1 phase was decreased in cells transfected with KNDC1-siRNA.


Regulatory relationship

Regulatory pathway: P53-P21-P16
R-AG-Pathway: --
Official symbol(s): TP53-CDKN1A-CDKN2A
Pathway experiment: Western blot
Pathway description: The phosphorylation of p53 and the expression of p21 and p16 decreased significantly compared with NT-siRNA-transfected control cells.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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