| Gene name: | RTEL1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Blood |
| Cell name: | Lymphoma cell line |
| Experiment: | Southern blot |
| Description: | Growth curves showing the population doublings of the LCLs over time. All LCLs carrying RTEL1 mutations reached a stage of growth arrest (indicated by red “X”). Interestingly, telomeres in LCLs derived from the parents, each carrying a single heterozygous RTEL1 mutation, were also shorter than those of the noncarrier S1 at a PDL of about 35. |
| Target gene: | TRF1 |
| Official symbol(s): | TERF1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | IP |
| Target gene description: | In addition, in a reciprocal experiment using FLAG-tagged TRF1 and TRF2, only FLAG-TRF1 was found to immunoprecipitate RTEL1.None of the mutations significantly affected the interaction of RTEL1 with TRF1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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