Aging Overview

Aging gene

Gene name: NOX4
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: VSMC
Gene ID: 50507
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 27655718
Experiment: SA-β-gal activity assay//BrdU assay
Description: The number of SA-β-gal-positive cells correlated inversely with the level of NOX4 expression obtained after transfection with different siRNA sequences.Moreover, cells with diminished NOX4 expression cease to proliferate since a significant decrease in the number of cells able to replicate DNA was observed already 3 days after transfection. These cells did not restart DNA replication during the next 4 days of the culture.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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