| Gene name: | MECP2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MSC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | We observed signs of senescence in cells treated with Ad‐siRNA‐MECP2, as detected by acid β‐galactosidase, when compared with cells transduced with Ad‐siRNA‐CTRL. |
| Regulatory pathway: | RB//P53 |
| R-AG-Pathway: | --//-- |
| Official symbol(s): | retinoblastoma//TP53 |
| Pathway experiment: | RT-PCR//Western blot |
| Pathway description: | In cells transduced with Ad‐siRNA‐MECP2, we observed an increase in RB gene expression at both the mRNA and protein levels and an increase in RB2/P130 gene expression at only the mRNA level. On in vitro MECP2 down‐regulation, we obtained evidence for significant changes in P53 mRNA levels, but no modification of the protein levels occurred. |
Annotation:
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