| Gene name: | MIR126 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | DPSCs |
| Experiment: | MTT assay |
| Description: | For control group, data displayed that there was no any influence, while miR‐126 caused a reduced cell proliferative rate.For DPSCs at PD54, miR‐126 inhibition significantly increased the cell replication of DPSCs during 72 hours post‐transfection. |
| Target gene: | PTEN |
| Official symbol(s): | PTEN |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//Western blot |
| Target gene description: | Here, the downregulation of PTEN was found in DPSC at PD54, compared with the DPSCs at PD16. Moreover, PTEN mRNA and protein level were also increased in senescent DPSCs transfected with miR‐126 inhibitor. |
| Regulatory pathway: | AKT |
| R-AG-Pathway: | Activation |
| Official symbol(s): | AKT1 |
| Pathway experiment: | Western blot |
| Pathway description: | The downstream Akt phosphorylation was remarkably upregulated in DPSCs at PD54, while transfection with miR‐126 inhibitor caused an impaired Akt phosphorylation in DPSCs. |
Annotation:
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