Aging Overview

Aging gene

Gene name: MDM2
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HCT116
Gene ID: 4193
Category: protein coding
Phenotype: Werner syndrome
Experimental category: L
PMID: 30532073
Experiment: SA-β-Gal activity assay
Description: Ectopic expression of WRN attenuates the senescent phenotype induced by Etoposide,as shown by senescence-associated β-galactosidase (SA-β-Gal) activity.


Regulatory relationship

Target gene: WRN
Official symbol(s): WRN
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: IP
Target gene description: WRN and MDM2 association was detected in co-transfected 293T cells by reciprocal immunoprecipitations.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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