| Gene name: | PAK4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U87 MG,LN-18 |
| Gene ID: | 10298 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | L |
| PMID: | 26297735 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | β3 knockdown also led to enhanced methylation of histone H3 in senescence-associated heterochromatin foci,increased γ-H2AX positive nuclei indicative of DNA double strand breaks,and accumulation of senescence-associted acidic β-galactosidase activity. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown//SA-β-gal activity assay |
| Target gene description: | Silencing of β3 induced a marked increased in p21 protein expression for multiple glioblastoma cells,whereas p21 levels were unchanged or even decreased following β3 knockdown in various epithelial cancer cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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