| Gene name: | MIR221 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A549 |
| Experiment: | SA-β-gal activity assay |
| Description: | A549-miR-221 cells induced cellular senescence following Cisplatin treatment as compared to A549-Cont cells, detected by SA-β-gal activity assay. |
| Regulatory pathway: | PTEN-AKT |
| R-AG-Pathway: | -- |
| Pathway experiment: | Western blot |
| Pathway description: | When miR-221 was ectopically expressed, PTEN was decreased and Akt activity was increased in H1299 cells. On the other hand, miR-221 antisense oligonucleotides (ASO) were used to suppress miR-221 activity, and upregulation of PTEN and downregulation of Akt activity in A549 cells were accompanied. |
Annotation:
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