| Gene name: | COL17A1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Hair |
| Cell name: | HFSC |
| Experiment: | Histological images analysis |
| Description: | We generated HFSC-specificCol17a1-deficient mice (Col17a1cKO). We found that those mice also show thinning hair and graying hair.The heat map for the global transcriptome of activated HFSC fractions (aHFSCs) revealed a significantly close relationship between Col17a1cKO HFSCs and aged HFSCs. Most of those mice showed significantly fewer miniaturized HFs and an apparent retardation of hair loss even in mice surving for 24 months (N = 3 mice) and 32 months (N = 2 mice). |
| Target gene: | ELANE |
| Official symbol(s): | ELANE |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Indeed, primary keratinocytes treated with ELANE showed that both the 180-kD COL17A1 and its shed form of the 120 kD ectodomain are quickly degraded by ELANE in vitro. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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