| Gene name: | AR |
| Aging type: | Accelerate |
| Aging characteristic: | Others |
| Tissue type: | Skin |
| Cell name: | DPC |
| Gene ID: | 367 |
| Category: | protein coding |
| Phenotype: | Androgenetic alopecia |
| Experimental category: | L |
| PMID: | 24244503 |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//SAHF//Immunostaining//Western blot |
| Description: | Overexpression of the AR increased both percentage of SA-β-Gal–positive cells and cell size and DHT enhanced the AR effects.A quantitative analysis showed that DHT induced SAHF formation in DPCs, and overexpression of the AR reinforced the effects of DHT compared with vector control-transfected cells.Western blot analyses showed that H2AX had been converted to its phosphorylated form (γ-H2AX) in DPCs in response to DHT, and the c-H2AX/total H2AX ratio was further increased in cells overexpressing the AR. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | To gain insight into the mechanism of premature senescence induction in DPCs, we focused on the relationship between the AR and p16INK4aprotein, which is known to be involved in premature senescence and is upregulated in balding DPCs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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