| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Peripheral Blood |
| Cell name: | BOEC |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Chronic obstructive pulmonary disease |
| Experimental category: | L |
| PMID: | 23897750 |
| Experiment: | SA-β-gal activity assay |
| Description: | We next confirmed the protective role of SIRT1 against senescence in BOEC, as inhibition of SIRT1 increased SA-β-gal activity in SIRT1-deficient BOEC compared to control siRNA-treated cells, both in baseline and oxidant conditions.There was a significant negative correlation between both SIRT1 protein levels and activity and SA-β-gal staining in all samples. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Inhibition of SIRT1 expression in BOEC, which caused increased senescence, also resulted in increased acetylation of p53 at Lys-382, suggesting that the protective effect of SIRT1 against senescence in BOEC may be in part mediated by deacetylation of p53. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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