| Gene name: | UBE2I |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U2OS |
| Experiment: | Growth curve assay |
| Description: | Under senescence promoting conditions there is a clear delay for the onset ofsenescence in U2OS when cells express the wild type form of UBC9 while the K49R variant shows no effect and undergoes senescence like the control cells. |
| Target gene: | PML |
| Official symbol(s): | PML |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Growth curve assay |
| Target gene description: | As expected, both Ubc9-PML and Ubc9K49R-PML fusion proteins localized to nuclear bodies.Expressing either Ubc9-PML or Ubc9K49R-PML fusion proteins counteracted the senescence induced by PML as compared to GFP-PML fusion in control cells . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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