Aging Overview

Aging gene

Gene name: IGFBP6
Aging type: Prevent
Aging characteristic: Others
Tissue type: --
Cell name: HDF
Gene ID: 3489
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 21820463
Experiment: BrdU assay//SA-β-gal activity assay//Growth curve assay
Description: At the end of the lifespan, overexpression of IGFBP-6 enabled the cells to perform 4– 5 additional population doublings.This was accompanied by a significant increase in the cell proliferation rate as measured by BrdU incorporation and a significant decrease in apoptotic cell death determined by Annexin V-staining and propidium iodide staining at 90–95% of lifespan completed. 120 days after infection (ca. 95% of lifespan completed), nearly all the cells in the controls stained SA-β-gal positive, whereas roughly 50% of the IGFBP-6 expressing cells stained still SA-β-gal negative and displayed reduced p21Waf1/Cip1 protein expression relative to controls.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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