| Gene name: | RB1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MSC |
| Experiment: | MTT assay//Alizarin red S staining//Western blot//qRT-PCR//SA-β-gal activity assay |
| Description: | Overexpression of RB in late-passage MSCs increased the proliferation rate and differentiation potentials; decreased the expression of senescence-associated markers such as p21, p16, and APO-1; and reduced β-gal staining. |
| Target gene: | DNMT |
| Official symbol(s): | DNMT1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | As expected, overexpression of RB in late-passage MSCs increased the protein levels of DNMT1.We found that c-JUN knockdown reduced DNMT1 expression in early- passage MSCs, but not late-passage MSCs, although the expression of RB in early-passage MSCs was not suppressed. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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