Aging Overview

Aging gene

Gene name: SKP2
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: MEF
Gene ID: 6502
Category: protein coding
Phenotype: Prostate cancer
Experimental category: L
PMID: 20237562
Experiment: SA-β-gal activity assay
Description: We also found that the ability of Ras to induce cellular senescence was far greater in Skp2-/- MEFs than in wild-type MEFs.


Regulatory relationship

Target gene: P27//P21//ATF4
Official symbol(s): P27//P21//ATF4
R-AG-Target gene: --//--//--
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: Although p53 and p19Arf levels remained unchanged, we found that Skp2 deficiency cooperated with Pten inactivation or Arf loss to induce p27 expression. p21 expression was also increased in Pten+/- Skp2-/- and Arf-/- Skp2-/- MEFs.In contrast, Atf4 was markedly induced in Pten+/- Skp2-/- MEFs. Likewise, we also observed a marked increase in Atf4 protein levels, but not p-Perk, in Arf-/- Skp2-/- MEFs.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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