Gene name: | SKP2 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | -- |
Cell name: | MEF |
Gene ID: | 6502 |
Category: | protein coding |
Phenotype: | Prostate cancer |
Experimental category: | L |
PMID: | 20237562 |
Experiment: | SA-β-gal activity assay |
Description: | We also found that the ability of Ras to induce cellular senescence was far greater in Skp2-/- MEFs than in wild-type MEFs. |
Target gene: | P27//P21//ATF4 |
Official symbol(s): | P27//P21//ATF4 |
R-AG-Target gene: | --//--//-- |
Subcategory: | Unclear |
Target gene experiment: | Western blot |
Target gene description: | Although p53 and p19Arf levels remained unchanged, we found that Skp2 deficiency cooperated with Pten inactivation or Arf loss to induce p27 expression. p21 expression was also increased in Pten+/- Skp2-/- and Arf-/- Skp2-/- MEFs.In contrast, Atf4 was markedly induced in Pten+/- Skp2-/- MEFs. Likewise, we also observed a marked increase in Atf4 protein levels, but not p-Perk, in Arf-/- Skp2-/- MEFs. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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