| Gene name: | POLE2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Experiment: | Cell counting//EdU assay//SA-β-gal activity assay//RT-qPCR//Knockdown |
| Description: | To this end, we tested several DNA repair genes by knocking-down their expression in human fibroblasts. Strikingly, knock-down of POLE2, BARD1, FEN1, RAD51, EXO1, BRCA1, or BLM alone was able to induce hallmarks of premature senescence. |
| Regulatory pathway: | P53-P21-RB |
| R-AG-Pathway: | -- |
| Official symbol(s): | RB1-CDKN1A-TP53 |
| Pathway experiment: | qRT-PCR |
| Pathway description: | Furthermore, Nutlin-3 or AT7519 notably repressed DNA repair gene expression through a P53/ P21/RB pathway. |
Annotation:
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