| Gene name: | CAV1 |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | Foreskin |
| Cell name: | Fibroblast |
| Experiment: | Western blot//Cell morphological analysis |
| Description: | We observed that a simple reduction in the caveolin-1 status, as determined by the siRNA method, induced in senescent cells morphological changes corresponding to the NA NA young cell-like shape, i.e. a small and spindle shape. |
| Target gene: | FAK//RAC1//CDC42 |
| Official symbol(s): | FAK//RAC1//CDC42 |
| R-AG-Target gene: | --//Activation//Activation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Cell morphological analysis//IP |
| Target gene description: | The phosphorylation of FAK was dramatically reduced by the down-regulation of caveolin-1 in caveolin siRNA-transfected senescent cells versus the control firefly luciferase siRNA-transfected senescent cells.Reductions of focal adhesion and actin stress fiber formation via the inactivation of FAK by caveolin-1 status reduction resulted in morphological alterations toward the young cell phenotype.Rho GTPases were recruited into caveolin fractions and were directly linked with caveolin-1 in senescent HDF cells by immunoprecipitation analysis. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...