| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCA2 |
| Experiment: | Immunostaining |
| Description: | SIRT6 reduced the number of γH2AX foci. |
| Target gene: | PARP1 |
| Official symbol(s): | PARP1 |
| R-AG-Target gene: | Inhibition |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Autoradiography |
| Target gene description: | Instead, we used the specific PARP1 inhibitor PJ34. Importantly, PJ34 had no inhibitory effect on either deacetylation or mono-ADP ribosylation activities of SIRT6.In the presence of PJ34, SIRT6 overexpression had no effect on HR,indicating that SIRT6-mediated rescue of HR in aging cells is dependent on PARP1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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