| Gene name: | SOCS1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay |
| Description: | Expression of SOCS1 inhibited cell growth and induced senescence, characterized by senescence-associated β-galactosidase staining and the accumulation of PML bodies. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Activation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot//Luciferase reporter assay |
| Target gene description: | Intriguingly, during SOCS1-induced senescence, the increase in p53 levels was accompanied with serine 15 phosphorylation of p53.SOCS1 was not able to activate the p53 reporter alone, but it did increase the activity of added p53 to a similar extent as PML. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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