| Gene name: | MEF2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | VSMC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Our results showed that over-expression of MEF2A significantly enhanced senescence compared with the cells in the EGFP group. Consistently, MEF2A knockdown inhibited VSMC senescence. |
| Target gene: | MIR-143 |
| Official symbol(s): | MIR-143 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//qRT-PCR |
| Target gene description: | After viral transfection for 24 h, we performed RT-qPCR analysis to confirm MEF2A overexpression in VSMCs with a corresponding increase in miR-143 expression compared to cells transduced with EGFP. Consistently, MEF2A knockdown in VSMCs resulted in down-regulated miR-143. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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