Gene name: | TP63 |
Aging type: | Prevent |
Aging characteristic: |
Tissue type: | Foreskin |
Cell name: | keratinocyte,JHU-011,JHU-029 |
Gene ID: | 8626 |
Category: | protein coding |
Phenotype: | Skin cancer |
Experimental category: | L |
PMID: | 17018588 |
Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry//Cell morphological analysis |
Description: | Induction of the cell cycle inhibitor p21CIP1 was observed following knockdown of p63 expression by RNAi in primary human keratinocytes and was associated with an increase in G1-phase cells and a marked decrease in S phase.Little or no evidence of cell death was observed in primary human keratinocytes following lentiviral p63 knockdown. Instead, morphologic features of cellular senescence were observed in a subset of cells, and these changes correlated with staining for SA-β-gal. |
Regulatory pathway: | -- |
R-AG-Pathway: | -- |
Pathway experiment: | -- |
Pathway description: | -- |
Annotation:
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