Aging Overview

Aging gene

Gene name: TP63
Aging type: Prevent
Aging characteristic:
Tissue type: Foreskin
Cell name: keratinocyte,JHU-011,JHU-029
Gene ID: 8626
Category: protein coding
Phenotype: Skin cancer
Experimental category: L
PMID: 17018588
Experiment: SA-β-gal activity assay//Knockdown//Flow cytometry//Cell morphological analysis
Description: Induction of the cell cycle inhibitor p21CIP1 was observed following knockdown of p63 expression by RNAi in primary human keratinocytes and was associated with an increase in G1-phase cells and a marked decrease in S phase.Little or no evidence of cell death was observed in primary human keratinocytes following lentiviral p63 knockdown. Instead, morphologic features of cellular senescence were observed in a subset of cells, and these changes correlated with staining for SA-β-gal.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...