| Gene name: | SIRT3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Nucleus pulposus tissue |
| Cell name: | Nucleus pulposus cell |
| Gene ID: | 23410 |
| Category: | protein coding |
| Phenotype: | Disc degenerative disease |
| Experimental category: | L |
| PMID: | 30420619 |
| Experiment: | SA-β-gal activity assay//Knockdown//Western blot |
| Description: | The results of the Western blot analysis showed that SIRT3 knockdown augmented the senescence marker protein expression of p16INKa, while SIRT3 overexpression suppressed the p16INKa level under TBHP-induced oxidative stress conditions.Compared to the NPCs transfected with scramble lentivirus, the percentage of SA-β-gal-positive staining cells in the SIRT3 knockdown group was increased, whereas SIRT3 overexpression suppressed the percentage of senescent cells under conditions of oxidative stress. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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