Aging Overview

Aging gene

Gene name: MIR106B
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: MTMEC
Gene ID: 406900
Category: ncRNA
Phenotype: Breast cancer
Experimental category: HL
PMID: 24270410
Experiment: SA-β-gal activity assay//EdU assay
Description: Overexpression of the miR-106bB25 cluster allowed cells to bypass doxorubicin-induced senescence and increased the capacity of MTMEC cells to generate doxorubicin-resistant cells.


Regulatory relationship

Target gene: EP300
Official symbol(s): EP300
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Luciferase reporter assay
Target gene description: To experimentally confirm that EP300 mRNA was a target of the miR-106bB25 cluster, we used a luciferase reporter with the 30 -UTR of EP300 and transiently transfected either control or cells overexpressing the cluster or individual miRs. In all cases, luciferase expression from the plasmid containing the EP300 30 -UTR was lower in cells overexpressing both the miR-106bB25 cluster and its individual miRs.which overexpress the miR-106bB25 cluster,showed reduced EP300 and CDH1, but increased VIM(encoding vimentin, a mesenchymal intermediate filament protein activated during EMT4) mRNA levels.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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