| Gene name: | TP53 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HN 30,HN 31 |
| Gene ID: | 7157 |
| Category: | protein coding |
| Phenotype: | Squamous cell carcinoma |
| Experimental category: | L |
| PMID: | 22090360 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Expression of disruptive TP53 mutations (C176F and E336X) led to decreased SA-β-gal activity compared with empty vector control.metformin decreased clonogenic survival following radiation and increased radiation-induced SA-β-gal activity in HN 31 cells (C176F, disruptive TP53), but had little effect in HN 30 cells (wild type TP53) . Furthermore, after inhibition of wild type p53 expression, metformin was found to potentiate SA-β-gal activity and decrease clonogenic survival. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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