Aging Overview

Aging gene

Gene name: GPX7
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: OE33,FLO-1
Gene ID: 2882
Category: protein coding
Phenotype: Oesophageal adenocarcinoma
Experimental category: L
PMID: 23580780
Experiment: Growth curve assay//SA-β-gal activity assay//Flow cytometry//Western blot//Colony formation assay
Description: Using stable ( pcDNA-GPX7) and transient reconstitution models of GPX7 in OAC cell lines, we detected a significant reduction in growth rates in GPX7-expressing cells.Our analysis demonstrated that GPX7-expressing OAC cells (OE33 and FLO-1) had a significant increase in β-galactosidase staining (p≤0.01), as compared with control cells.About half of the control cells (Ad-CTRL) had proceeded tothe middle S phase after 4 h while only 32.4% ofGPX7-expressing cells (Ad-GPX7) proceeded to the early S phase.


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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