| Gene name: | LINC00858 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Colon cancer tissues |
| Cell name: | HCT116 |
| Gene ID: | 170425 |
| Category: | ncRNA |
| Phenotype: | Colorectal cancer |
| Experimental category: | HL |
| PMID: | 32768499 |
| Experiment: | SA-β-gal activity assay |
| Description: | The results of β-gal staining, immunofluorescence staining, and Western blot analysis demonstrated that the senescence and autophagy of cells treated with sh-NC + sh-WNK2 were reduced in parallel with diminished expression of Beclin-1 and LC3II/I, in contrast to findings in cells treated with sh-NC + sh-NC (p < 0.05). However, opposite effects were observed in cells treated with sh-LINC00858 + sh-WNK2 when compared with sh-NC + sh-WNK2 (p <0.05). |
| Target gene: | WNK2 |
| Official symbol(s): | WNK2 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The results from Western blot analysis showed that, compared with cells treated with sh-NC (of WNK2) + sh-NC (of LINC00858), WNK2 expression was reduced in cells treated with sh-NC + sh-WNK2, while its expression was elevated in cells treated with sh-LINC00858 + sh-WNK2 when compared with cells treated with sh-NC + sh-WNK2 (p < 0.05). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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