| Gene name: | LMNA |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Mice |
| Cell name: | -- |
| Experiment: | Knockdown//Immunostaining |
| Description: | The body weight of Lmna?/?mice began to decline at the 10th week of age, while the weight of wild mice continued to increase, showing that, at that stage, the Lmna?/? mice started to lose weight, indicating a decline in the metabolic state of their body.A signifcant increase in the number of p16INK4aexpressing cells was observed in the BAT of Lmna?/?mice (64.33±2.333% versus 50.33±2.603,P = 0.0161). |
| Target gene: | UCP1//BETA3-AR//PRDM16 |
| Official symbol(s): | UCP1//BETA3-AR//PRDM16 |
| R-AG-Target gene: | --// --// -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | UCP1 and beta3-AR protein levels in Lmna?/?mice were significantly lower than those in WT mice at 14 weeks of age (UCP1: 0.04740.0089versus 1.000±0.0666, P =0.0001; beta3-AR: 3143±0.0329 versus 1.000±0.0445, P = 0.0002).Both the protein and mRNA levels of PRDM16 were decreased at the age of 14 weeks in Lmna?/?mice. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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