Aging Overview

Aging gene

Gene name: ID4
Aging type: Accelerate
Aging characteristic: Others
Tissue type: --
Cell name: DU 145
Gene ID: 3400
Category: protein coding
Phenotype: Prostate cancer
Experimental category: L
PMID: 24122992
Experiment: SA-β-gal activity assay//Western blot//Immunostaining
Description: Enlarged morphology and accumulation of cytoplasmic aggregates were observed in DU145+Id4 cells as compared to DU145 cells,indicative of senescence.An increase in senescence associated beta-galactosidase (SA-βgal) staining suggested that ectopic expression of Id4 in DU145 cells promotes senescence at a higher frequency than in un-transfected DU145 cells.Immunocytochemical analysis shown clearly indicate that Id4 up-regulates G1 cell- cycle regulators p21 and p2, as compared to DU145 cells. We also observed an increased p16 expression at protein and transcript levels in DU145+Id4 cells, compared to DU145 cells but its functional relevance in DU145 cells with respect to senescence remains obscure.


Regulatory relationship

Target gene: E2F1
Official symbol(s): E2F1
R-AG-Target gene: Downregulation
Subcategory: Unclear
Target gene experiment: Western blot
Target gene description: At 10 nm, a significant increase in senescence was not observed in DU145 cells. The basal (0 h) E2F1 expression was significantly lower in DU145+Id4 cells as compared to DU145 cells whereas E2F1 expression was almost undetectable in DU145+Id4 cells at subsequent time points.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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