Aging Overview

Aging gene

Gene name: FOXO3
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: HDF
Gene ID: 2309
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 15741276
Experiment: SA-β-gal activity assay//Cell morphological analysis//Western blot//Knockdown
Description: Senescence Phenotypes in FOXO3a-siRNA Cells Senescent cells are resistant to mitogen-induced proliferation , express senescence-associated β-gal, and have a characteri stically enlarged, flattened morphology. We measured cell growth and senescence-associated β-gal activity in FOXO3a-siRNA cells. FOXO3a-siRNA cells had an enlarged, flattened cell morphology, like old cells. The percentage of blue cells (indicating senescence-associated β-gal activity) was higher in FOXO3a-siRNA cells than in vectortransfected cells.As expected, the levels of p53 and p21 proteins were up-regulated in FOXO3a-siRNA cells as well as in old cells .


Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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